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DDF structures illustrated by Emily J. Wu and Ankita Kandalkara
Last updated on December 23, 2024.
DD: death domain; DED: death effector domain; CARD: caspase recruitment domain; PYD: pyrin domain. The work was supported by grants from the US National Institutes of Health.
Protein or complex | PDB ID | Image | Residues | 3D structure | Source Organism | Resolution (Å)-2 | Unitprot | Method | Publication |
|---|---|---|---|---|---|---|---|---|---|
FADD DD | 1FAD |  | 89-183 | 1FAD-3D | Mus musculus | - | Q61160 | NMR | 1999-Jeong |
FADD DD | 1E3Y |  | 89-192 | 1E3Y-3D | Homo sapiens | - | Q13158 | NMR | 2000-Berglund |
FADD DD | 1E41. |  | 89-192 | 1E41-3D | Homo sapiens | - | Q13158 | NMR | 2000-Berglund |
NLRP9 PYD | 6Z2G |  | 9-97 | 6Z2G-3D | Homo sapiens | 2.0 | Q7RTR0 | X-RAY | 2020-Marleaux |
RIG-I second CARD | 2LWD |  | 95-190 | 2LWD-3D | Homo sapiens | - | O95786 | NMR | 2012-Ferrage |
RIG-I second CARD, T170E | 2LWE |  | 95-190 | 2LWE-3D | Homo sapiens | - | O95786 | NMR | 2012-Ferrage |
CENP-N with the centromeric nucleosome containing CENP-A | 6C0W |  | 46-134 | 6C0W-3D | Homo sapiens, Escherichia coli str. 'clone D i2 | 4.0 | P49450 | EM | 2018-Cho |
CENP-A nucleosome bound by two copies of CENP-C(CD) and two copies CENP-N(NT) | 6MUP |  | 12-101 | 6MUP-3D | Homo sapiens | 4.0 | P49450 | EM | 2019-Allu |
CED-4 CARD: CED-3 CARD in apoptosome | 8JOL |  | 1-497 | 8JOL-3D | Caenorhabditis elegans | 3.0 | P30429 | EM | 2023-Li |
CARMA1 CARD dimer | 4JUP |  | 22-108 | 4JUP-3D | Homo sapiens | 3.0 | Q9BXL7 | X-RAY | 2013-Jang |
FAS DD: FADD (5-7:5) | 3OQ9 |  | 223-308 | 3OQ9-3D | Mus musculus, Homo sapiens | 7.0 | P25446, Q13158 | X-RAY | 2010-Wang |
Fas DD: FADD DD (4:4) | 3EZQ |  | 223-337 | 3EZQ-3D | Homo sapiens | 3.0 | P25445, Q13158 | X-RAY | 2009-Scott |
MALT1 DD | 8J5I |  | 28-124 | 8J5I-3D | Homo sapiens | 2.0 | Q9UDY8 | X-RAY | 2024 |
Pelle DD: Tube DD | 1D2Z |  | 28-129 | 1D2Z-3D | Drosophila melanogaster | 2.0 | Q05652, P22812 | X-RAY | 1999-Xiao |
IRAK4 DD | 2A9I |  | 3-107 | 2A9I-3D | Mus musculus | 2.0 | Q8R4K2 | X-RAY | 2005-Lasker |
Caspase-8 tDED | 4ZBW |  | 3-184 | 4ZBW-3D | Homo sapiens | 2.0 | Q14790 | X-RAY | 2015-Shen |
DR3 DD, C363G and MBP fused | 5ZNY |  | 3-450 | 5ZNY-3D | Escherichia coli K-12, Mus musculus | 3.0 | B1AWN9, P0AEX9 | X-RAY | 2019-Yin |
DR3 DD, I387V and MBP fused | 5ZNZ |  | 3-451 | 5ZNZ-3D | Escherichia coli K-12, Mus musculus | 3.0 | B1AWN9, P0AEX9 | X-RAY | 2019-Yin |
p75NTR DD | 4F44 |  | 3-85 | 4F44-3D | Rattus norvegicus | 2.0 | P07174 | X-RAY | 2013 |
cPOP1 PYD | 4QOB |  | 3-89 | 4QOB-3D | Homo sapiens | 3.0 | Q8WXC3 | X-RAY | 2014 |
CARD-like designed protein | 7VTY |  | 3-92 | 7VTY-3D | synthetic construct | 3.0 | X-RAY | 2023-Zhang | |
NLRP3 PYD filament | 7PZD |  | 3-94 | 7PZD-3D | Homo sapiens | 4.0 | Q96P20 | EM | 2022-Hochheiser |
CARD9 CARD dimer | 6E27. |  | 3-97 | 6E27-3D | Homo sapiens | 2.0 | Q9H257 | X-RAY | 2018-Holliday |
NLRP7 PYD | 2KM6 |  | 3-98 | 2KM6-3D | Homo sapiens | - | Q8WX94 | NMR | 2010-Pinheiro |
BinCARD CARD | 4DWN |  | 3-99 | 4DWN-3D | Homo sapiens | 2.0 | Q96LW7 | X-RAY | 2013-Chen |
TNFR1 DD | 1ICH |  | 327-412 | 1ICH-3D | Homo sapiens | - | P19438 | NMR | 2001-Sukits |
p75NTR DD: TRADD DD | 7CSQ |  | 330-427 | 7CSQ-3D | Homo sapiens | - | P08138, Q15628 | NMR | 2021-Zhang |
p75NTR DD | 1NGR |  | 334-418 | 1NGR-3D | Rattus norvegicus | - | P07174 | NMR | 1997-Liepinsh |
p75NTR DD symmetric dimer | 2N97 |  | 334-427 | 2N97-3D | Homo sapiens | - | P08138 | NMR | 2015-Lin |
p75NTR DD: RhoGDI | 2N80 |  | 334-427 | 2N80-3D | Homo sapiens | - | P08138,P52565 | NMR | 2015-Lin |
p75NTR DD: RIP2 CARD | 2N83 |  | 334-427 | 2N83-3D | Homo sapiens | - | P08138, O43353 | NMR | 2015-Lin |
MAVS CARD filament | 3J6C |  | 370-462 | 3J6C-3D | Homo sapiens | 10.0 | Q7Z434 | EM | 2014-Xu |
MDA5 tCARD: K63-polyUb | 7DNJ |  | 4-200 | 7DNJ-3D | Homo sapiens | 3.0 | Q9BYX4, P0CG47 | EM | 2021-Song |
DR3 DD, D412E | 5YGP |  | 4-456 | 5YGP-3D | Homo sapiens | 2.0 | P0AEX9, Q93038 | X-RAY | 2019-Yin |
Pyrin PYD | 2MPC |  | 4-93 | 2MPC-3D | Homo sapiens | - | O15553 | NMR | 2014-Vajjhala |
CENP-A nucleosome bound by two copies of CENP-C(CD) and one copy CENP-N(NT) | 6MUO |  | 41-139 | 6MUO-3D | Homo sapiens | 4.0 | P49450 | EM | 2019-Allu |
RIP2 CARD filament | 5YRN |  | 430-516 | 5YRN-3D | Homo sapiens | 4.0 | O43353 | EM | 2018-Gong |
cIAP1 CARD | 2L9M |  | 431-562 | 2L9M-3D | Homo sapiens | - | Q13490 | NMR | 2011-Lopez |
RIP2 CARD filament | 6GGS |  | 433-518 | 6GGS-3D | Homo sapiens | 4.0 | O43353 | EM | 2018-Pellegrini |
CARD8 CARD filament | 6XKJ |  | 451-535 | 6XKJ-3D | Homo sapiens | 4.0 | Q9Y2G2 | EM | 2021-Robert Hollingsworth |
CARD8 CARD filament | 6K9F |  | 451-537 | 6K9F-3D | Homo sapiens | 4.0 | Q9Y2G2 | EM | 2021-Gong |
CENP-A nucleosome in complex with CENP-N | 7U46 |  | 46-134 | 7U46-3D | Homo sapiens, Escherichia coli str. 'clone D i2 | 3.0 | P49450 | EM | 2022-Zhou |
CENP-N promoted nucleosome stacks with CENP-A and palindromic alpha satellite DNA sequence | 7U47 |  | 46-134 | 7U47-3D | Homo sapiens, Escherichia coli str. 'clone D i2 | 8.0 | P49450 | EM | 2022-Zhou |
CENP-N promoted nucleosome stacks with CENP-A and 601 DNA sequence | 7U4D |  | 46-134 | 7U4D-3D | Homo sapiens, Escherichia coli str. 'clone D i2 | 8.0 | P49450 | EM | 2022-Zhou |
NLRP3 PYD | 3QF2 |  | 5-94 | 3QF2-3D | Homo sapiens | 2.0 | Q96P20 | X-RAY | 2011-Bae |
NLRP4 PYD | 4EWI |  | 5-95 | 4EWI-3D | Homo sapiens | 2.0 | Q96MN2 | X-RAY | 2012-Eibl |
APAF-1 CARD | 1CWW |  | 5-97 | 1CWW-3D | Homo sapiens | - | O14727 | NMR | 1999-Day |
NLRP9 PYD | 7BSO |  | 5-97 | 7BSO-3D | Homo sapiens | 2.0 | Q7RTR0 | X-RAY | 2020-Ha |
RIPK1 DD, GlcNAcylated | 6AC5 |  | 574-670 | 6AC5-3D | Homo sapiens | 1.0 | Q13546 | X-RAY | 2019-Ding |
NALP1 PYD | 1PN5 |  | 59-151 | 1PN5-3D | Homo sapiens | - | P06654, Q9C000 | NMR | 2003-Hiller |
NLRP14 PYD | 4N1K |  | 6-93 | 4N1K-3D | Homo sapiens | 3.0 | Q86W24 | X-RAY | 2014-Eibl |
NLRP14 PYD | 4N1J |  | 6-96 | 4N1J-3D | Homo sapiens | 3.0 | Q86W24 | X-RAY | 2014-Eibl |
Caspase-8 tDED, isoform G | 7LVJ |  | 60-244 | 7LVJ-3D | Homo sapiens | 2.0 | Q14790 | X-RAY | 2022-Ansalone |
CED-4 CARD: CED-9 CARD | 2A5Y |  | 67-241 | 2A5Y-3D | Caenorhabditis elegans | 3.0 | P41958, P30429 | X-RAY | 2005-Yan |
NLRP14 PYD | 4N1L |  | 7-101 | 4N1L-3D | Homo sapiens | 2.0 | Q86W24 | X-RAY | 2014-Eibl |
vFLIP tDED | 2F1S |  | 7-183 | 2F1S-3D | Molluscum contagiosum virus subtype 1 | 1.0 | Q98325 | X-RAY | 2006-Li |
Pelle DD, unfolded by MPD | 1IK7 |  | 78-129 | 1IK7-3D | Drosophila melanogaster | 2.0 | Q05652 | X-RAY | 2002-Xiao |
CARD9 CARD filament | 6N2P |  | 8-95 | 6N2P-3D | Homo sapiens | 4.0 | Q9H257 | EM | 2019-Holliday |
UNC5H2 DD | 1WMG |  | 854-943 | 1WMG-3D | Mus musculus | 2.0 | Q8K1S3 | X-RAY | 2006-Handa |
PIDD DD: RAIDD DD (5: 7) | 2OF5 |  | 109-199 | 2OF5-3D | Homo sapiens | 3.0 | P78560, Q9HB75 | X-RAY | 2007-Park |
PEA-15 DED: ERK2 phosphomimetic mutant | 4IZ5 |  | 11-357 | 4IZ5-3D | Homo sapiens | 3.0 | P28482, Q15121 | X-RAY | 2013-Mace |
PEA-15 DED: Dually Phosphorylated ERK2 | 4IZA |  | 11-358 | 4IZA-3D | Homo sapiens | 2.0 | P28482,Q15121 | X-RAY | 2013-Mace |
PEA-15 DED: Non-Phosphorylated ERK2 | 4IZ7 |  | 11-359 | 4IZ7-3D | Homo sapiens, Cricetulus griseus | 2.0 | P28482, Q9Z297 | X-RAY | 2013-Mace |
ASC CARD filament | 6N1H |  | 112-194 | 6N1H-3D | Homo sapiens | 3.0 | Q9ULZ3 | EM | 2018-Li |
ASC CARD filament | 6K99 |  | 112-194 | 6K99-3D | Homo sapiens | 4.0 | Q9ULZ3 | EM | 2021-Gong |
NOD1 CARD | 2B1W |  | 12-110 | 2B1W-3D | Homo sapiens | - | Q9Y239 | NMR | 2007-Manon |
NLRP1 CARD | 3KAT |  | 1379-1462 | 3KAT-3D | Homo sapiens | 3.0 | Q9C000 | X-RAY | 2009 |
NLRP1 CARD filament | 6K7V |  | 1379-1462 | 6K7V-3D | Homo sapiens | 4.0 | Q9C000 | EM | 2021-Gong |
NLRP1 CARD filament | 6XKK |  | 1379-1463 | 6XKK-3D | Homo sapiens | 4.0 | Q9C000 | EM | 2021-Robert Hollingsworth |
p45 DD | 2IB1 |  | 138-228 | 2IB1-3D | Mus musculus | - | Q8CJ26 | NMR | 2007 |
Ankyrin-1 DD | 2YQF |  | 1387-1497 | 2YQF-3D | Homo sapiens | - | P16157 | NMR | 2007 |
Ankyrin-1 DD | 2YVI |  | 1397-1485 | 2YVI-3D | Homo sapiens | 2.0 | P16157 | X-RAY | 2007 |
NLRP6 PYD filament | 6NCV |  | 14-104 | 6NCV-3D | Homo sapiens | 4.0 | P59044 | EM | 2019-Shen |
NOD1 CARD dimer | 4E9M |  | 14-110 | 4E9M-3D | Homo sapiens | 2.0 | Q9Y239 | X-RAY | 2012 |
NRADD DD | 6HJ7 |  | 145-246 | 6HJ7-3D | Mus musculus | - | Q8CJ26 | NMR | 2019-Nadezhdin |
NLRP6 PYD, MBP fused | 6NDJ |  | 15-1086 | 6NDJ-3D | Escherichia coli K-12, Homo sapiens | 2.0 | P0AEX9, P59044 | X-RAY | 2019-Shen |
NOD1 CARD dimer | 2NSN |  | 16-110 | 2NSN-3D | Homo sapiens | 2.0 | Q9Y239 | X-RAY | 2007-Coussens |
Caspase-8 tDED | 5JQE |  | 18-1182 | 5JQE-3D | Escherichia coli | 3.0 | P0AEX9, Q14790 | X-RAY | 2016-Fu |
MyD88 DD filament | 6I3N |  | 19-121 | 6I3N-3D | Homo sapiens | 3.0 | Q99836 | EM | 2020-Moncrieffe |
MyD88 DD: IRAK4 DD: IRAK2 DD (6:4:4) | 3MOP |  | 19-123 | 3MOP-3D | Homo sapiens | 3.0 | Q99836, Q9NWZ3, O43187 | X-RAY | 2010-Lin |
TRADD DD, GlcNAcylated | 6AC0 |  | 198-312 | 6AC0-3D | Homo sapiens | 1.0 | Q15628 | X-RAY | 2019-Ding |
TRADD DD | 5XME |  | 199-312 | 5XME-3D | Homo sapiens | - | Q15628 | NMR | 2017-Zhang |
Ankyrin-G DD | 4O6X |  | 2-101 | 4O6X-3D | Homo sapiens | 2.0 | Q12955 | X-RAY | 2014-Liu |
vFLIP tDED: IKK𝛾 coiled coil dimer | 3CL3 |  | 2-173 | 3CL3-3D | Human gammaherpesvirus 8, Homo sapiens | 3.0 | Q76RF1 | X-RAY | 2008-Bagneris |
Caspase-8 tDED | 6AGW |  | 2-180 | 6AGW-3D | Homo sapiens | 2.0 | Q14790 | X-RAY | 2019-Park |
Caspase-8 tDED dimer | 5H33 |  | 2-182 | 5H33-3D | Homo sapiens | 4.0 | Q14790 | X-RAY | 2016 |
Caspase-8 tDED filament | 5L08 |  | 2-182 | 5L08-3D | Homo sapiens | 5.0 | Q14790 | EM | 2016-Fu |
FADD DED: Caspase-8 tDED: cFLIP tDED | 8YBX |  | 2-182 | 8YBX-3D | Homo sapiens | 4.0 | Q14790, O15519, Q13158 | EM | 2024-Yang |
Caspase-8 tDED dimer | 5H31 |  | 2-183 | 5H31-3D | Homo sapiens | 3.0 | Q14790 | X-RAY | 2016 |
vFLIP tDED | 2BBZ |  | 2-191 | 2BBZ-3D | Molluscum contagiosum virus subtype 1 | 4.0 | Q98325 | X-RAY | 2005-Yang |
DR3 DD | 5YEV |  | 2-254 | 5YEV-3D | Mus musculus | 3.0 | P0AEX9, Q93038 | X-RAY | 2019-Yin |
AIM2 PYD, MBP fused | 3VD8 |  | 2-335 | 3VD8-3D | Escherichia coli O157:H7, Homo sapiens | 2.0 | O14862, P0AEY0 | X-RAY | 2013-Jin |
DR3 DD | 5YGS |  | 2-457 | 5YGS-3D | Homo sapiens | 3.0 | P0AEX9, Q93038 | X-RAY | 2019-Yin |
RIP2 CARD, MBP fused | 6GFJ |  | 2-458 | 6GFJ-3D | Methanosarcina mazei, Homo sapiens | 3.0 | O43353 | X-RAY | 2018-Pellegrini |
NLRP1 CARD | 4IFP |  | 2-459 | 4IFP-3D | Escherichia coli K-12, Homo sapiens | 2.0 | P0AEX9, Q9C000 | X-RAY | 2013-Jin |
NLRP12 PYD, MBP fused | 5H7N |  | 2-460 | 5H7N-3D | Homo sapiens | 2.0 | P0AEX9, P59046 | X-RAY | 2017-Jin |
ASC CARD | 5GPQ |  | 2-461 | 5GPQ-3D | Escherichia coli O157:H7, Danio rerio | 2.0 | P0AEX9, Q9I9N6 | X-RAY | 2018-Li |
ASC PYD | 5GPP |  | 2-462 | 5GPP-3D | Escherichia coli O157:H7, Danio rerio | 2.0 | P0AEX9, Q9I9N6 | X-RAY | 2018-Li |
MNDA PYD, MBP fused | 5WQ6 |  | 2-468 | 5WQ6-3D | Homo sapiens | 2.0 | P0AEX9 | X-RAY | 2017-Jin |
MNDA PYD, MBP fused | 5H7Q |  | 2-470 | 5H7Q-3D | Homo sapiens | 1.0 | P0AEX9, P41218 | X-RAY | 2017-Jin |
p75NTR DD | 4F42 |  | 2-85 | 4F42-3D | Rattus norvegicus | 2.0 | P07174 | X-RAY | 2013 |
Caspase-1 CARD: ASC CARD octamer | 7KEU |  | 2-86 | 7KEU-3D | Homo sapiens | 4.0 | P29466, Q9ULZ3 | EM | 2021-Robert Hollingsworth |
ICEBERG CARD | 1DGN |  | 2-90 | 1DGN-3D | Homo sapiens | - | P57730 | NMR | 2000-Humke |
ASC PYD filament | 2N1F |  | 2-90 | 2N1F-3D | Mus musculus | 4.0 | Q9EPB4 | ssNMR, EM | 2015-Sborgi |
CARD9 CARD dimer | 6E28. |  | 2-97 | 6E28-3D | Homo sapiens | 1.0 | Q9H257 | X-RAY | 2018-Holliday |
BinCARD CARD, F16M/L66M | 4FH0 |  | 2-98 | 4FH0-3D | Homo sapiens | 1.0 | Q96LW7 | X-RAY | 2013-Chen |
CARMA1 CARD | 4I16 |  | 20-109 | 4I16-3D | Mus musculus | 2.0 | Q8CIS0 | X-RAY | 2012-Li |
FAS DD | 1DDF |  | 201-327 | 1DDF-3D | Homo sapiens | - | P25445 | NMR | 1996-Huang |
CARMA1 CARD | 4LWD |  | 21-110 | 4LWD-3D | Homo sapiens | 2.0 | Q9BXL7 | X-RAY | 2013-Qiao |
CARD9 CARD dimer | 6N2M |  | 1-142 | 6N2M-3D | Homo sapiens | - | Q9H257 | NMR | 2019-Holliday |
NOD1 CARD | 2NZ7 |  | 1-148 | 2N27-3D | Homo sapiens | 2.0 | Q9Y239 | X-RAY | 2008-Srimathi |
cFLIP tDED | 7DEE |  | 1-185 | 7DEE-3D | Homo sapiens | - | O15519 | NMR | 2020-Bai |
Caspase-8 tDED, isoform B | 7LVM |  | 1-185 | 7LVM-3D | Homo sapiens | 1.0 | Q14790 | X-RAY | 2022-Ansalone |
cFLIP tDED | 6M6O |  | 1-185 | 6M6O-3D | Homo sapiens | - | O15519 | NMR | 2022-Bai |
RIG-I tCARD: ubiquitin | 4NQK |  | 1-187 | 4NQK-3D | Homo sapiens | 4.0 | O95786, P0CG48 | X-RAY | 2014-Peisley |
RIG-I tCARD: MAVS CARD | 4P4H |  | 1-188 | 4P4H-3D | Homo sapiens | 3.0 | O95786, Q7Z434, P62987 | X-RAY | 2014-Wu |
FADD DED + DD | 2GF5 |  | 1-191 | 2GF5-3D | Homo sapiens | - | Q13158 | NMR | 2006-Carrington |
ASC PYD CARD | 2KN6 |  | 1-195 | 2KN6-3D | Homo sapiens | - | Q9ULZ3 | NMR | 2009-de Alba |
ASC PYD Domain and Rb-B7 | 7E5B |  | 1-266 | 7E5B-3D | Cyclostomata, Homo sapiens | 2.0 | Q9ULZ3 | X-RAY | 2022-Cho |
APAF-1 CARD in ADP form | 1Z6T |  | 1-336 | 1Z6T-3D | Homo sapiens | 2.0 | O14727 | X-RAY | 2005-Riedl |
NLRP12 PYD dimer, MBP fused | 4XHS |  | 1-458 | 4XHS-3D | Escherichia coli O157:H7, Homo sapiens | 2.0 | P0AEX9 | X-RAY | 2016 |
MNDA PYD, MBP fused | 5WPZ |  | 1-460 | 5WPZ-3D | Homo sapiens | 2.0 | P0AEX9, P41218 | X-RAY | 2017-Jin |
GBP CARD, MBP fused | 4IRL |  | 1-462 | 4IRL-3D | Escherichia coli K-12, Danio rerio | 1.0 | B0V1H4, P0AEX9 | X-RAY | 2013-Jin |
CARD8 CARD, MBP fused | 4IKM |  | 1-463 | 4IKM-3D | Escherichia coli K-12, Homo sapiens | 2.0 | P0AEX9, Q9Y2G2 | X-RAY | 2013-Jin |
MDA5 tCARD: MAVS CARD: polyUb | 7DNI |  | 1-73 | 7DNI-3D | Homo sapiens | 3.0 | P0CG47, Q9BYX4, Q7Z434 | EM | 2021-Song |
FADD DED, F25G | 1A1Z |  | 1-83 | 1A1Z-3D | Homo sapiens | - | Q13158 | NMR | 1998-Eberstadt |
FADD DED, F25Y | 1A1W |  | 1-83 | 1A1W-3D | Homo sapiens | - | Q13158 | NMR | 1998-Eberstadt |
Caspase-1 CARD filament | 5FNA |  | 1-85 | 5FNA-3D | Homo sapiens | 5.0 | P29466 | EM | 2016-Lu |
NLRC4-CARD filament | 6N1I |  | 1-85 | 6N1I-3D | Homo sapiens | 4.0 | Q9NPP4 | EM | 2018-Li |
NLRC4 CARD filament | 6K8J |  | 1-85 | 6K8J-3D | Homo sapiens | 3.0 | Q9NPP4 | EM | 2021-Gong |
cFLIP DED1, engineered | 7LXC |  | 1-88 | 7LXC-3D | Homo sapiens | - | O15519, Q13158 | NMR | 2022-Panaitiu |
ASC2 PYD | 2HM2 |  | 1-89 | 2HM2-3D | Homo sapiens | - | Q8WXC3 | NMR | 2006-Natarajan |
PEA-15 DED | 2LS7 |  | 1-90 | 2LS7-3D | Mus musculus | - | Q62048 | NMR | 2012-Twomey |
NLRC4 CARD filament | 6MKS |  | 1-90 | 6MKS-3D | Homo sapiens, Vaccinia virus | 3.0 | P42212, Q9NPP4 | EM | 2018-Matyszewski |
PEA-15 DED | 6P6B |  | 1-90 | 6P6B-3D | Homo sapiens | - | Q15121 | NMR | 2019-Crespo-Flores |
PEA-15 DED, upon ERK2 interaction | 6P6C |  | 1-90 | 6P6C-3D | Homo sapiens | - | Q15121 | NMR | 2019-Crespo-Flores |
APAF-1 CARD | 2YGS |  | 1-91 | 2YGS-3D | Homo sapiens | 2.0 | O14727 | X-RAY | 1999-Qin |
ASC PYD | 1UCP |  | 1-91 | 1UCP-3D | Homo sapiens | - | Q9ULZ3 | NMR | 2003-Liepinsh |
ASC PYD filament | 3J63 |  | 1-91 | 3J63-3D | Homo sapiens | 4.0 | Q9ULZ3 | EM | 2014-Lu |
NLRP3 PYD | 2NAQ |  | 1-91 | 2NAQ-3D | Homo sapiens | - | Q96P20 | NMR | 2016-Oroz |
APAF-1 CARD | 1CY5 |  | 1-92 | 1CY5-3D | Homo sapiens | 1.0 | O14727 | X-RAY | 1999-Vaughn |
Ifi205b PYD | 2YU0 |  | 1-94 | 2YU0-3D | Mus musculus | - | P0DOV1 | NMR | 2007 |
APAF-1 CARD | 2P1H |  | 1-94 | 2P1H-3D | Homo sapiens | 2.0 | O14727 | X-RAY | 2007-Milam |
MAVS CARD R64C | 4O9F |  | 1-94 | 4O9F-3D | Equus caballus | 2.0 | F6QPU3 | X-RAY | 2014-Xu |
Orf64R CARD | 6J52 |  | 1-94 | 6J52-3D | Frog virus 3 | 3.0 | W8SPG9 | X-RAY | 2019-Kim |
APAF-1 CARD: Caspase-9 CARD | 3YGS |  | 1-95 | 3YGS-3D | Homo sapiens | 3.0 | O14727, P55211 | X-RAY | 1999-Qin |
Apaf-1 CARD: Caspase-9 CARD | 4RHW |  | 1-95 | 4RHW-3D | Homo sapiens | 2.0 | O14727, P55211 | X-RAY | 2014-Hu |
AIM2 PYD | 2N00 |  | 1-95 | 2N00-3D | Mus musculus | - | Q91VJ1 | NMR | 2015-Hou |
APAF-1 CARD: Caspase-9 CARD | 5WVC |  | 1-95 | 5WVC-3D | Homo sapiens | 3.0 | O14727, P55211 | X-RAY | 2017-Su |
AIM2 PYD filament | 7K3R |  | 1-95 | 7K3R-3D | Homo sapiens | 3.0 | O14862 | EM | 2021-Matyszewski |
NLRP3 PYD filament | 8ERT |  | 1-95 | 8ERT-3D | Homo sapiens | 3.0 | Q96P20 | EM | 2023-Xiao |
APAF-1 CARD | 1C15 |  | 1-97 | 1C15-3D | Homo sapiens | - | O14727 | NMR | 1999-Zhou |
MAVS CARD filament | 3J6J |  | 1-97 | 3J6J-3D | Homo sapiens | 4.0 | Q7Z434 | EM | 2014-Wu |
Bcl10 CARD | 2MB9 |  | 10-115 | 2MB9-3D | Homo sapiens | - | O95999 | NMR | 2013-Qiao |
BCL10 CARD filament | 6BZE |  | 10-115 | 6BZE-3D | Homo sapiens | 4.0 | O95999 | EM | 2018-David |
BCL10 CARD: MALT1 DD filament | 6GK2 |  | 10-115 | 6GK2-3D | Homo sapiens | 5.0 | O95999 | EM | 2018-Schlauderer |
BCL10 CARD filament, R58Q | 8CZD |  | 10-115 | 8CZD-3D | Homo sapiens | 5.0 | O95999 | EM | 2022-Xia |
APAF-1 CARD: Caspase-9 CARD in apoptosome | 5WVE | | 105-1248 | 5WVE-3D | Homo sapiens, Equus caballus | 4.0 | O14727, P55211, P00004(Ec) | EM | 2017-Li |
RAIDD DD | 2O71 |  | 109-199 | 2O71-3D | Homo sapiens | 2.0 | P78560 | X-RAY | 2006-Park |
MAVS CARD | 2MS8 |  | 1-100 | 2MS8-3D | Homo sapiens | - | Q7Z434 | NMR | 2016-He |
MAVS CARD filament | 2MS7 |  | 1-100 | 2MS7-3D | Homo sapiens | - | Q7Z434 | ssNMR | 2016-He |
FADD DD: NleB | 6ACI |  | 1-329 | 6ACI-3D | Escherichia coli O127:H6 str. E2348/69, Homo sapiens | 2.0 | B7UI21, Q13158 | X-RAY | 2019-Ding |
MAVS CARD E26R | 4O9L |  | 1-94 | 4O9L-3D | Equus caballus | 2.0 | F6QPU3 | X-RAY | 2014-Xu |
RIG-I tCARD | 6BZH |  | 2-188 | 6BZH-3D | Mus musculus | 3.0 | Q6Q899 | X-RAY | 2018-D'Cruz |
Designed Apaf-1-like CARD | 6JCC |  | 2-94 | 6JCC-3D | synthetic construct | 1.0 | X-RAY | 2019 | |
MALT1 DD | 2G7R |  | 29-48 | 2G7R-3D | Homo sapiens | 3.0 | Q9UDY8 | X-RAY | 2006 |
APAF-1 CARD | 8XQK |  | 1-92 | 8XQK-3D | Homo sapiens | 3.0 | O14727 | X-RAY | 2024 |
vFLIP tDED | 2BBR |  | 2-188 | 2BBR-3D | Molluscum contagiosum virus subtype 1 | 1.0 | Q98325 | X-RAY | 2005-Yang |
UNC5b DD | 3G5B |  | 541-826 | 3G5B-3D | Rattus norvegicus | 2.0 | O08722 | X-RAY | 2009-Wang |
CED-4 CARD in apoptosome | 3LQQ |  | 1-416 | 3LQQ-3D | Caenorhabditis elegans | 4.0 | P30429 | X-RAY | 2010-Qi |
CED-4 CARD: CED-3 CARD | 3LQR |  | 1-416 | 3LQR-3D | Caenorhabditis elegans | 4.0 | P30429 | X-RAY | 2010-Qi |
cIAP1 CARD | 3T6P |  | 264-362 | 3T6P-3D | Homo sapiens | 2.0 | Q13490 | X-RAY | 2011-Dueber |
RIG-I tCARD | 4A2Q |  | 1-186 | 4A2Q-3D | Anas platyrhynchos | 3.0 | D3TI84 | X-RAY | 2011-Kowalinkski |
RIG-I tCARD | 4A2W |  | 1-330 | 4A2W-3D | Anas platyrhynchos | 4.0 | D3TI84 | X-RAY | 2011-Kowalinkski |
DARK CARD in apoptosome | 4V4L |  | 1-583 | 4V4L-3D | Drosophila melanogaster | 7.0 | Q7KLI1 | EM | 2011-Yuan |
Ankyrin-B DD | 4D8O |  | 964-1079 | 4D8O-3D | Homo sapiens | 2.0 | Q01484 | X-RAY | 2012-Wang |
CED-4 CARD: CED-3 CARD | 4M9S |  | 1-417 | 4M9S-3D | Caenorhabditis elegans | 3.0 | P30429 | X-RAY | 2013-Huang |
CED-4 CARD: CED-3 CARD | 4M9X |  | 1-417 | 4M9X-3D | Caenorhabditis elegans | 3.0 | P30429 | X-RAY | 2013-Huang |
CED-4 CARD: CED-3 CARD | 4M9Y |  | 1-417 | 4M9Y-3D | Caenorhabditis elegans | 4.0 | P30429 | X-RAY | 2013-Huang |
CED-4 CARD: CED-3 CARD | 4M9Z |  | 1-417 | 4M9Z-3D | Caenorhabditis elegans | 3.0 | P30429 | X-RAY | 2013-Huang |
ARC CARD | 4UZ0 |  | 1-417 | 4UZ0-3D | Homo sapiens | 2.0 | O60936 | X-RAY | 2015-Jang |
Dark CARD in apoptosome | 3J9L |  | 10-334 | 3J9L-3D | Drosophila melanogaster | 4.0 | Q7KLI1 | EM | 2015-Pang |
Dark CARD: Dronc CARD in apoptosome | 3J9K |  | 10-334 | 3J9K-3D | Drosophila melanogaster | 4.0 | Q7KLI1, Q9XYF4 | EM | 2015-Pang |
APAF1 CARD: Caspase-9 CARD | 5JUY |  | 105-789 | 5JUY-3D | Homo sapiens | 4.0 | O14727, P55211, P62894(Bos) | EM | 2016-Cheng |
vFLIP tDED: IKK𝛾 stapled dimer | 5LDE |  | 20-54 | 5LDE-3D | Human gammaherpesvirus 8, Homo sapiens | 3.0 | F5HEZ4, P19909, Q9Y6K9 | X-RAY | 2017-Briggs |
Caspase-11 CARD | 6KXG |  | 5-423 | 6KXG-3D | Mus musculus | 3.0 | P0AEX9 | X-RAY | 2020-Liu |
vFLIP tDED, R12E | 7PDJ |  | 1-116 | 7PDJ-3D | Human gammaherpesvirus 8 | 4.0 | F5HEZ4 | X-RAY | 2022-Bagneris |
BCL10 CARD: MALT1 DD filament | 8CZO |  | 29-63 | 8CZO-3D | Homo sapiens | 4.0 | Q9UDY8, O95999 | EM | 2022-Xia |
CED-4 CARD in hexamer | 8JNS |  | 1-416 | 8JNS-3D | Caenorhabditis elegans | 4.0 | P30429 | EM | 2023-Li |
FADD DED: Caspase-8 tDED: cFLIP tDED | 8YD7 |  | 2-121 | 8YD7-3D | Homo sapiens | 3.0 | O15519, Q14790, Q13158 | X-RAY | 2024-Yang |
FADD DED: Caspase-8 tDED: cFLIP tDED | 8YD8 |  | 1-121 | 8YD8-3D | Homo sapiens | 3.0 | O15519, Q14790, Q13158 | X-RAY | 2024-Yang |
AIM2 PYD filament | 6MB2 |  | 1-93 | 6MB2-3D | Homo sapiens, Aequorea victoria | 5.0 | O14862, P42212 | EM | 2015-Lu |
AIM2 PYD, F27G | 4O7Q |  | 0-93* | 4O7Q-3D | Homo sapiens | 2.0 | O14862 | X-RAY | 2014-Lu |
p105 DD | 2DBF |  | 1-100 | 2DBF-3D | Homo sapiens | - | P19838 | NMR | 2006 |
RAIDD CARD | 3CRD |  | 1-100 | 3CRD-3D | Homo sapiens | - | P78560 | NMR | 1998-Chou |
NLRC5 CARD | 2MJM |  | 1-101 | 2MJM-3D | Mus musculus | - | C3VPR6 | NMR | 2014-Gutte |
DR6 DD | 2DBH |  | 1-102 | 2DBH-3D | Homo sapiens | - | O75509 | NMR | 2006 |
NLRP12 PYD | 2L6A |  | 1-102 | 2L6A-3D | Homo sapiens | - | P59046 | NMR | 2011-Pinheiro |
NLRP10 PYD | 2M5V |  | 1-102 | 2M5V-3D | Homo sapiens | - | Q86W26 | NMR | 2013-Su |
MNDA PYD | 2DBG |  | 1-103 | 2DBG-3D | Homo sapiens | - | P41218 | NMR | 2005 |
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