Statistics

The Death Domain Database documents 181 PPI pairs among 99 DDS by curating 311 peer-reviewed publications.

Number of curated publicationsExternal

1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 Total
1 5 11 18 11 25 20 29 28 19 24 10 13 21 11 23 11 18 13 311

Number of PPI pairs

CARD
Death Domain # of PPI pairs
Apaf1 5
ASC 5
Bcl-10 11
BinCARD 1
CARD6 4
CARD8 6
CARD9 3
CARD10 1
CARD11 2
CARD12 6
CARD14 1
CARD16 7
CARD17 4
CARD18 5
Caspase1 12
Caspase2 6
Caspase4 3
Caspase5 1
Caspase9 6
Caspase12 3
CIAP1 2
CIAP2 3
DLG5 0
MAVS 3
MDA5 2
NLRP1 8
NOD1 7
NOD2 5
NOL3 1
QRICH1 0
RAIDD 2
RIG-1 4
RIPK2 12
   
   
   
   
DD
Death Domain # of PPI pairs
ANK1 0
ANK2 0
ANK3 2
ANKDD1A 0
ANKDD1B 0
DAPK1 3
DR3 4
DR4 5
DR5 6
DR6 1
DTHD1 0
EDAR 1
EDARADD 2
FADD 13
Fas 6
IRAK1 6
IRAK2 5
IRAK3 4
IRAK4 3
MADD 6
MALT1 1
Myd88 7
NF-kB1 1
NF-kB2 1
NGFR 3
PIDD 4
RAIDD 2
RIP 9
THOC1 0
TNFR1 8
TNFRSF11B 0
TRADD 11
UNC5A 0
UNC5B 1
UNC5C 0
UNC5CL 0
UNC5D 0
DED
Death Domain # of PPI pairs
Caspase8 7
Caspase10 4
DEDD 5
DEDD2 5
FADD 5
FLIP 6
PEA15 2
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
PYD
Death Domain # of PPI pairs
POP1 1
POP2 3
AIM2 2
ASC 12
IFI16 1
MNDA 0
NLRP1 3
NLRP2 3
NLRP3 2
NLRP4 0
NLRP5 0
NLRP6 0
NLRP7 1
NLRP8 0
NLRP9 0
NLRP10 2
NLRP11 0
NLRP12 1
NLRP13 0
NLRP14 0
PYHIN1 0
Pyrin 1
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   

Comparison of experimentally verified PPI databases

CARD
Death Domain # of PPI pairs
IntAct Mint DD.org
Apaf1 1 1 5
ASC 0 0 5
Bcl-10 0 2 11
BinCARD 0 1 1
CARD6 0 0 4
CARD8 0 2 6
CARD9 0 0 3
CARD10 0 0 1
CARD11 0 1 2
CARD12 1 1 6
CARD14 0 0 1
CARD16 0 0 7
CARD17 0 0 4
CARD18 0 0 5
Caspase1 0 2 12
Caspase2 2 1 6
Caspase4 0 0 3
Caspase5 1 0 1
Caspase9 1 2 6
Caspase12 1 0 3
CIAP1 1 0 2
CIAP2 0 0 3
DLG5 0 0 0
MAVS 1 0 3
MDA5 0 0 2
NLRP1 2 0 8
NOD1 1 2 7
NOD2 0 1 5
NOL3 1 1 1
QRICH1 0 0 0
RAIDD 1 1 2
RIG-1 2 0 4
RIPK2 1 4 12
DD
Death Domain # of PPI pairs
IntAct Mint DD.org
ANK1 0 0 0
ANK2 0 0 0
ANK3 0 0 2
ANKDD1A 0 0 0
ANKDD1B 0 0 0
DAPK1 0 1 3
DR3 0 0 4
DR4 2 1 5
DR5 1 2 6
DR6 0 0 1
DTHD1 0 0 0
EDAR 0 0 1
EDARADD 0 0 2
FADD 1 3 13
Fas 3 1 6
IRAK1 4 3 6
IRAK2 4 3 5
IRAK3 4 3 4
IRAK4 2 0 3
MADD 0 0 6
MALT1 0 0 1
Myd88 4 3 7
NF-kB1 0 1 1
NF-kB2 0 1 1
NGFR 0 0 3
PIDD 1 2 4
RAIDD 1 1 2
RIP 2 3 9
THOC1 0 0 0
TNFR1 2 1 8
TNFRSF11B 0 0 0
TRADD 2 4 11
UNC5A 0 0 0
UNC5B 0 0 1
UNC5C 0 0 0
UNC5CL 0 0 0
UNC5D 0 0 0
DED
Death Domain # of PPI pairs
IntAct Mint DD.org
Caspase8 0 4 7
Caspase10 4 2 4
DEDD 0 0 5
DEDD2 0 0 5
FADD 1 2 5
FLIP 2 1 6
PEA15 0 0 2
PYD
Death Domain # of PPI pairs
IntAct Mint DD.org
POP1 0 0 1
POP2 0 0 3
AIM2 0 0 2
ASC 1 1 12
IFI16 0 0 1
MNDA 0 0 0
NLRP1 1 0 3
NLRP2 0 0 3
NLRP3 0 0 2
NLRP4 0 0 0
NLRP5 0 0 0
NLRP6 0 0 0
NLRP7 0 0 1
NLRP8 0 0 0
NLRP9 0 0 0
NLRP10 0 0 2
NLRP11 0 0 0
NLRP12 0 0 1
NLRP13 0 0 0
NLRP14 0 0 0
PYHIN1 0 0 0
Pyrin 0 1 1