ASC / CARD12 (CARD)
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In vitro interaction | |||||||||||||
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DD1 | DD2 | Reference | |||||||||||
Family | DD1 | DD2 | Method | Species | Region | Expression | Species | Region | Expression | ||||
CARD | ASC |
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CARD12 | GST fusion protein pull-down | Human | 105-195 | In vitro translation | Human | 1-88 | E.coli | 11967258 | ||
CARD | ASC |
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CARD12 | GST fusion protein pull-down | Human | Full length | In vitro translation | Human | 1-88 | E.coli | 11967258 | ||
CARD | ASC |
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CARD12 | Two-hybrid | Not specified | Not specified | HEK293 | Not specified | 1-83 | HEK293 | 11374873 | ||
CARD | ASC |
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CARD12 | Yeast two-hybrid | Human | Full length | Yeast | Human | 1-96 | Yeast | 19337385 |
(
: click this icon to show interactions only between the two corresponding DDs)

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In vivo interaction | |||||||||||||
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Endogenous expression |
Overexpression | DD1 | DD2 | Reference | |||||||||
Family | DD1 | DD2 | Method | Species | Region | Species | Region | ||||||
CARD | ASC |
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CARD12 | Co-immunoprecipitation | HEK293 | Not specified | Full length | Not specified | 1-647 | 12646168 | |||
CARD | ASC |
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CARD12 | Co-immunoprecipitation | HEK293 | Human | Not specified | Human | 1-457 | 15701651 |
(
: click this icon to show interactions only between the two corresponding DDs)

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Functional Role | |||||||||||
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Family | DD1 | DD2 | Method | Death-related | Death-unrelated | Reference | |||||
CARD | ASC |
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CARD12 | β-galactosidase staining, Luciferase assay | Apoptosis | NF-kB activation | 12646168 |
(
: click this icon to show interactions only between the two corresponding DDs)
