ASC / CARD12 (CARD)

Interactions between ASC in detail and CARD12 in detail (CARD)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vitro interaction
  DD1 DD2 Reference
Family DD1 DD2 Method Species Region Expression Species Region Expression
CARD ASC Link CARD12 GST fusion protein pull-down Human 105-195 In vitro translation Human 1-88 E.coli 11967258
CARD ASC Link CARD12 GST fusion protein pull-down Human Full length In vitro translation Human 1-88 E.coli 11967258
CARD ASC Link CARD12 Two-hybrid Not specified Not specified HEK293 Not specified 1-83 HEK293 11374873
CARD ASC Link CARD12 Yeast two-hybrid Human Full length Yeast Human 1-96 Yeast 19337385
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
CARD ASC Link CARD12 Co-immunoprecipitation HEK293 Not specified Full length Not specified 1-647 12646168
CARD ASC Link CARD12 Co-immunoprecipitation HEK293 Human Not specified Human 1-457 15701651
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Functional Role
Family DD1 DD2 Method Death-related Death-unrelated Reference
CARD ASC Link CARD12 β-galactosidase staining, Luciferase assay Apoptosis NF-kB activation 12646168
(Link: click this icon to show interactions only between the two corresponding DDs)