Caspase1 / RIPK2 (CARD)

Interactions between Caspase1 in detail and RIPK2 in detail (CARD)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vitro interaction
  DD1 DD2 Reference
Family DD1 DD2 Method Species Region Expression Species Region Expression
CARD Caspase1 Link RIPK2 GST fusion protein pull-down Not specified 1-92 In vitro translation Not specified 454-540 E.coli 11051551
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Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
CARD Caspase1 Link RIPK2 Co-immunoprecipitation HEK293 Human 2-540 Human 2-92 9705938
CARD Caspase1 Link RIPK2 Co-immunoprecipitation HEK293 Not specified Full length Not specified Not specified 11051551
CARD Caspase1 Link RIPK2 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 11536016
CARD Caspase1 Link RIPK2 Co-immunoprecipitation HEK293 Human 2-540 Murine Not specified 15039421
CARD Caspase1 Link RIPK2 Co-immunoprecipitation HEK293 Human 431-540 Murine Not specified 15039421
CARD Caspase1 Link RIPK2 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 16585594
CARD Caspase1 Link RIPK2 Co-immunoprecipitation THP-1 16585594
CARD Caspase1 Link RIPK2 Co-immunoprecipitation HEK239 Human Not specified Not specified Not specified 21862576
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Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Characterization
  Stoichiometry Affinity Protein-Protein interface Reference
Family DD1 DD2 Method Mutation Complex structure
CARD Caspase1 Link RIPK2 Co-immunoprecipitation D27G, R45D (Caspase1) 21862576
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Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Functional Role
Family DD1 DD2 Method Death-related Death-unrelated Reference
CARD Caspase1 Link RIPK2 Caspase cleaved assay Pro-caspase1 activation 9705938
CARD Caspase1 Link RIPK2 Caspase cleaved assay Caspase1 activation 11051551
CARD Caspase1 Link RIPK2 Reporter gene assay NF-kB activation 15039421
CARD Caspase1 Link RIPK2 Luciferase assay NF-kB activation 16585594
(Link: click this icon to show interactions only between the two corresponding DDs)