NOD1 / RIPK2 (CARD)

Interactions between NOD1 in detail and RIPK2 in detail (CARD)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vitro interaction
  DD1 DD2 Reference
Family DD1 DD2 Method Species Region Expression Species Region Expression
CARD NOD1 Link RIPK2 GST fusion protein pull-down Not specified 17-138 E.coli Not specified 435-528 E.coli 22470564
CARD NOD1 Link RIPK2 Yeast two-hybrid Human 1-145 Yeast Not specified Full length Yeast 10224040
CARD NOD1 Link RIPK2 Yeast two-hybrid Human 1-145 Yeast Not specified 384-540 Yeast 10224040
CARD NOD1 Link RIPK2 Yeast two-hybrid Human 1-110 Yeast Human 427-527 Yeast 19337385
CARD NOD1 Link RIPK2 Yeast two-hybrid Human 16-108 Yeast Human 427-527 Yeast 19337385
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
CARD NOD1 Link RIPK2 Co-immunoprecipitation HEK293 Human Full length Not specified Full length 10224040
CARD NOD1 Link RIPK2 Co-immunoprecipitation HEK293 Human Full length Not specified 374-540 10329646
CARD NOD1 Link RIPK2 Co-immunoprecipitation HEK293 Human Full length Not specified Not specified 11463746
CARD NOD1 Link RIPK2 Co-immunoprecipitation HEK293 Not specified 1-158 Not specified 365-531 12459189
CARD NOD1 Link RIPK2 Co-immunoprecipitation HEK293 Human Full length Not specified Full length 17054981
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Characterization
  Stoichiometry Affinity Protein-Protein interface Reference
Family DD1 DD2 Method Mutation Complex structure
CARD NOD1 Link RIPK2 Co-immunoprecipitation V41Q(NOD1) 10329646
CARD NOD1 Link RIPK2 Co-immunoprecipitation E53K, D54K, E56K (NOD1) R444E, R483E, R488E (RIPK2) 17054981
CARD NOD1 Link RIPK2 GST fusion protein pull-down D461A, E472A, E475A, E492A (RIPK2) 22470564
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Functional Role
Family DD1 DD2 Method Death-related Death-unrelated Reference
CARD NOD1 Link RIPK2 Luciferase assay NF-kB activation 10329646
CARD NOD1 Link RIPK2 Reporter gene assay NF-kB activation (Nodosome) 11463746
(Link: click this icon to show interactions only between the two corresponding DDs)