RIPK2 / NOD1 (CARD)

Interactions between RIPK2 in detail and NOD1 in detail (CARD)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vitro interaction
  DD1 DD2 Reference
Family DD1 DD2 Method Species Region Expression Species Region Expression
CARD RIPK2 Link NOD1 GST fusion protein pull-down Not specified 435-528 E.coli Not specified 17-138 E.coli 22470564
CARD RIPK2 Link NOD1 Yeast two-hybrid Not specified Full length Yeast Human 1-145 Yeast 10224040
CARD RIPK2 Link NOD1 Yeast two-hybrid Not specified 384-540 Yeast Human 1-145 Yeast 10224040
CARD RIPK2 Link NOD1 Yeast two-hybrid Human 427-527 Yeast Human 1-110 Yeast 19337385
CARD RIPK2 Link NOD1 Yeast two-hybrid Human 427-527 Yeast Human 16-108 Yeast 19337385
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
CARD RIPK2 Link NOD1 Co-immunoprecipitation HEK293 Not specified Full length Human Full length 10224040
CARD RIPK2 Link NOD1 Co-immunoprecipitation HEK293 Not specified 374-540 Human Full length 10329646
CARD RIPK2 Link NOD1 Co-immunoprecipitation HEK293 Not specified Not specified Human Full length 11463746
CARD RIPK2 Link NOD1 Co-immunoprecipitation HEK293 Not specified 365-531 Not specified 1-158 12459189
CARD RIPK2 Link NOD1 Co-immunoprecipitation HEK293 Not specified Full length Human Full length 17054981
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Characterization
  Stoichiometry Affinity Protein-Protein interface Reference
Family DD1 DD2 Method Mutation Complex structure
CARD RIPK2 Link NOD1 Co-immunoprecipitation V41Q(NOD1) 10329646
CARD RIPK2 Link NOD1 Co-immunoprecipitation E53K, D54K, E56K (NOD1) R444E, R483E, R488E (RIPK2) 17054981
CARD RIPK2 Link NOD1 GST fusion protein pull-down D461A, E472A, E475A, E492A (RIPK2) 22470564
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Functional Role
Family DD1 DD2 Method Death-related Death-unrelated Reference
CARD RIPK2 Link NOD1 Luciferase assay NF-kB activation 10329646
CARD RIPK2 Link NOD1 Reporter gene assay NF-kB activation (Nodosome) 11463746
(Link: click this icon to show interactions only between the two corresponding DDs)