RIPK2 / NOD1 (CARD)
![]() ![]() ![]() ![]() |
![]() |
In vitro interaction | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DD1 | DD2 | Reference | |||||||||||
Family | DD1 | DD2 | Method | Species | Region | Expression | Species | Region | Expression | ||||
CARD | RIPK2 |
![]() |
NOD1 | GST fusion protein pull-down | Not specified | 435-528 | E.coli | Not specified | 17-138 | E.coli | 22470564 | ||
CARD | RIPK2 |
![]() |
NOD1 | Yeast two-hybrid | Not specified | Full length | Yeast | Human | 1-145 | Yeast | 10224040 | ||
CARD | RIPK2 |
![]() |
NOD1 | Yeast two-hybrid | Not specified | 384-540 | Yeast | Human | 1-145 | Yeast | 10224040 | ||
CARD | RIPK2 |
![]() |
NOD1 | Yeast two-hybrid | Human | 427-527 | Yeast | Human | 1-110 | Yeast | 19337385 | ||
CARD | RIPK2 |
![]() |
NOD1 | Yeast two-hybrid | Human | 427-527 | Yeast | Human | 16-108 | Yeast | 19337385 |
(
: click this icon to show interactions only between the two corresponding DDs)

![]() ![]() ![]() ![]() |
![]() |
In vivo interaction | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Endogenous expression |
Overexpression | DD1 | DD2 | Reference | |||||||||
Family | DD1 | DD2 | Method | Species | Region | Species | Region | ||||||
CARD | RIPK2 |
![]() |
NOD1 | Co-immunoprecipitation | HEK293 | Not specified | Full length | Human | Full length | 10224040 | |||
CARD | RIPK2 |
![]() |
NOD1 | Co-immunoprecipitation | HEK293 | Not specified | 374-540 | Human | Full length | 10329646 | |||
CARD | RIPK2 |
![]() |
NOD1 | Co-immunoprecipitation | HEK293 | Not specified | Not specified | Human | Full length | 11463746 | |||
CARD | RIPK2 |
![]() |
NOD1 | Co-immunoprecipitation | HEK293 | Not specified | 365-531 | Not specified | 1-158 | 12459189 | |||
CARD | RIPK2 |
![]() |
NOD1 | Co-immunoprecipitation | HEK293 | Not specified | Full length | Human | Full length | 17054981 |
(
: click this icon to show interactions only between the two corresponding DDs)

![]() ![]() ![]() ![]() |
![]() |
Characterization | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Stoichiometry | Affinity | Protein-Protein interface | Reference | ||||||||
Family | DD1 | DD2 | Method | Mutation | Complex structure | ||||||
CARD | RIPK2 |
![]() |
NOD1 | Co-immunoprecipitation | V41Q(NOD1) | 10329646 | |||||
CARD | RIPK2 |
![]() |
NOD1 | Co-immunoprecipitation | E53K, D54K, E56K (NOD1) R444E, R483E, R488E (RIPK2) | 17054981 | |||||
CARD | RIPK2 |
![]() |
NOD1 | GST fusion protein pull-down | D461A, E472A, E475A, E492A (RIPK2) | 22470564 |
(
: click this icon to show interactions only between the two corresponding DDs)

![]() ![]() ![]() ![]() |
![]() |
Functional Role | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Family | DD1 | DD2 | Method | Death-related | Death-unrelated | Reference | |||||
CARD | RIPK2 |
![]() |
NOD1 | Luciferase assay | NF-kB activation | 10329646 | |||||
CARD | RIPK2 |
![]() |
NOD1 | Reporter gene assay | NF-kB activation (Nodosome) | 11463746 |
(
: click this icon to show interactions only between the two corresponding DDs)
