RIPK2 / NOD2 (CARD)

Interactions between RIPK2 in detail and NOD2 in detail (CARD)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vitro interaction
  DD1 DD2 Reference
Family DD1 DD2 Method Species Region Expression Species Region Expression
CARD RIPK2 Link NOD2 GST fusion protein pull-down Not specified 435-528 E.coli Not specified 28-218 E.coli 22470564
CARD RIPK2 Link NOD2 Yeast two-hybrid Human 427-527 Yeast Human 1-267 Yeast 19337385
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Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
CARD RIPK2 Link NOD2 Co-immunoprecipitation HEK293 Not specified Full length Human Full length 11087742
CARD RIPK2 Link NOD2 Co-immunoprecipitation HEK293 Not specified Full length Human 1-744 11087742
CARD RIPK2 Link NOD2 Co-immunoprecipitation HEK293 Not specified Full length Human 1-301 11087742
CARD RIPK2 Link NOD2 Co-immunoprecipitation HEK293 Not specified 374-540 Human Full length 11087742
CARD RIPK2 Link NOD2 Co-immunoprecipitation HEK293 Not specified Not specified Mouse Not specified 15620648
CARD RIPK2 Link NOD2 Co-immunoprecipitation HEK293 Not specified Not specified Mouse Not specified 18775659
CARD RIPK2 Link NOD2 Co-immunoprecipitation HEK293 Not specified Full length Not specified Not specified 19464198
CARD RIPK2 Link NOD2 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 22665475
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Characterization
  Stoichiometry Affinity Protein-Protein interface Reference
Family DD1 DD2 Method Mutation Complex structure
CARD RIPK2 Link NOD2 GST fusion protein pull-down R38A, R86A (NOD2) D461A, E472A, D473A, E475A, D492A (RIPK2) 22470564
CARD RIPK2 Link NOD2 Yeast two-hybrid E69K, D70K (Nod2) 19337385
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Functional Role
Family DD1 DD2 Method Death-related Death-unrelated Reference
CARD RIPK2 Link NOD2 Luciferase assay NF-kB activation(Nodosome) 11087742
CARD RIPK2 Link NOD2 ELISA NF-kB activation (Nodosome) 18775659
(Link: click this icon to show interactions only between the two corresponding DDs)