DR4 / FADD (DD)

Interactions between DR4 in detail and FADD in detail (DD)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vitro interaction
  DD1 DD2 Reference
Family DD1 DD2 Method Species Region Expression Species Region Expression
DD DR4 Link FADD Affinity purification-mass spectrometry H460cell lyaste H460cell lyaste 19427028
DD DR4 Link FADD GST fusion protein pull-down Not specified 269-468 E.coli HeLa lysate 12920112
DD DR4 Link FADD Yeast two-hybrid Not specified 272-469 Yeast Not specified Full length Yeast 15452120
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
DD DR4 Link FADD Co-immunoprecipitation HEK293 Human 106-468 Human Not specified 9430227
DD DR4 Link FADD Co-immunoprecipitation HEK293 Not specified 261-465 Not specified 80-208 9430228
DD DR4 Link FADD Co-immunoprecipitation BAJB Not specified 272-469 Not specified Full length 15452120
DD DR4 Link FADD Co-immunoprecipitation HeLa 16980609
DD DR4 Link FADD Co-immunoprecipitation SW948 21272366
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Functional Role
Family DD1 DD2 Method Death-related Death-unrelated Reference
DD DR4 Link FADD β-galactosidase staining Apoptosis (DISC) 9430227
DD DR4 Link FADD Cytoplasmic histone associated DNA fragment detection Apoptosis (DISC) 9430228
DD DR4 Link FADD Caspase cleaved assay Caspase8 activation 15452120
DD DR4 Link FADD Immunofluorescence staining Apoptosis (DISC) 21272366
DD DR4 Link FADD Annexin V staining Apoptosis (DISC) 12920112
(Link: click this icon to show interactions only between the two corresponding DDs)