DR5 / FADD (DD)

Interactions between DR5 in detail and FADD in detail (DD)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vitro interaction
  DD1 DD2 Reference
Family DD1 DD2 Method Species Region Expression Species Region Expression
DD DR5 Link FADD GST fusion protein pull-down Not specified 191-411 E.coli Jurkat lysate 12721308
DD DR5 Link FADD GST fusion protein pull-down Not specified 209-411 E.coli HeLa lysate 12920112
DD DR5 Link FADD Yeast two-hybrid Not specified 209-412 Yeast Not specified Full length Yeast 15173180
DD DR5 Link FADD Yeast two-hybrid Not specified 209-412 Yeast Not specified Full length Yeast 15452120
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
DD DR5 Link FADD Co-immunoprecipitation HEK293 Human 51-411 Human Not specified 9430227
DD DR5 Link FADD Co-immunoprecipitation HEK293 Not specified 232-439 Not specified 80-208 9430228
DD DR5 Link FADD Co-immunoprecipitation BJAB 15173180
DD DR5 Link FADD Co-immunoprecipitation HeLa Not specified 79-208 Not specified 272-469 15173180
DD DR5 Link FADD Co-immunoprecipitation BJAB Not specified 209-412 Not specified Full length 15452120
DD DR5 Link FADD Co-immunoprecipitation HepG2 16980609
DD DR5 Link FADD Co-immunoprecipitation HeLa 17585340
DD DR5 Link FADD Co-immunoprecipitation SW948 21272366
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Functional Role
Family DD1 DD2 Method Death-related Death-unrelated Reference
DD DR5 Link FADD β-galactosidase staining Apoptosis (DISC) 9430227
DD DR5 Link FADD Cytoplasmic histone associated DNA fragment detection Apoptosis (DISC) 9430228
DD DR5 Link FADD Caspase cleaved assay Caspase8 activation 15452120
DD DR5 Link FADD Immunofluorescence staining Apoptosis (DISC) 21272366
DD DR5 Link FADD Annexin V staining Apoptosis (DISC) 12920112
(Link: click this icon to show interactions only between the two corresponding DDs)