EDAR / EDARADD (DD)

Interactions between EDAR in detail and EDARADD in detail (DD)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vitro interaction
  DD1 DD2 Reference
Family DD1 DD2 Method Species Region Expression Species Region Expression
DD EDAR Link EDARADD GST fusion protein pull-down Not specified 212-448 E.coli Human Not specified In vitro translation 11780064
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
DD EDAR Link EDARADD Co-immunoprecipitation HEK293 Not specified 212-448 Human Not specified 11780064
DD EDAR Link EDARADD Co-immunoprecipitation HEK293 Mouse Full length Human Not specified 17354266
DD EDAR Link EDARADD Co-immunoprecipitation HEK293 Not specified Not specified Human Not specified 20222921
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Characterization
  Stoichiometry Affinity Protein-Protein interface Reference
Family DD1 DD2 Method Mutation Complex structure
DD EDAR Link EDARADD GST fusion protein pull-down E142K (EDARADD) 11780064
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Functional Role
Family DD1 DD2 Method Death-related Death-unrelated Reference
DD EDAR Link EDARADD Luciferase assay NF-kB activation 11780064
DD EDAR Link EDARADD Luciferase assay NF-kB activation 17354266
(Link: click this icon to show interactions only between the two corresponding DDs)