FADD / DR4 (DD)

Interactions between FADD in detail and DR4 in detail (DD)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vitro interaction
  DD1 DD2 Reference
Family DD1 DD2 Method Species Region Expression Species Region Expression
DD FADD Link DR4 Affinity purification-mass spectrometry H460cell lyaste H460cell lyaste 19427028
DD FADD Link DR4 GST fusion protein pull-down HeLa lysate Not specified 269-468 E.coli 12920112
DD FADD Link DR4 Yeast two-hybrid Not specified Full length Yeast Not specified 272-469 Yeast 15452120
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
DD FADD Link DR4 Co-immunoprecipitation HEK293 Human Not specified Human 106-468 9430227
DD FADD Link DR4 Co-immunoprecipitation HEK293 Not specified 80-208 Not specified 261-465 9430228
DD FADD Link DR4 Co-immunoprecipitation BAJB Not specified Full length Not specified 272-469 15452120
DD FADD Link DR4 Co-immunoprecipitation HeLa 16980609
DD FADD Link DR4 Co-immunoprecipitation SW948 21272366
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Functional Role
Family DD1 DD2 Method Death-related Death-unrelated Reference
DD FADD Link DR4 β-galactosidase staining Apoptosis (DISC) 9430227
DD FADD Link DR4 Cytoplasmic histone associated DNA fragment detection Apoptosis (DISC) 9430228
DD FADD Link DR4 Caspase cleaved assay Caspase8 activation 15452120
DD FADD Link DR4 Immunofluorescence staining Apoptosis (DISC) 21272366
DD FADD Link DR4 Annexin V staining Apoptosis (DISC) 12920112
(Link: click this icon to show interactions only between the two corresponding DDs)