IRAK1 / Myd88 (DD)

Interactions between IRAK1 in detail and Myd88 in detail (DD)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
DD IRAK1 Link Myd88 Co-immunoprecipitation HEK293 Not specified Full length Not specified 1-151 9430229
DD IRAK1 Link Myd88 Co-immunoprecipitation HEK293 Not specified Full length Not specified 1-151 10383454
DD IRAK1 Link Myd88 Co-immunoprecipitation THP-1 10811644
DD IRAK1 Link Myd88 Co-immunoprecipitation HEK293 Not specified Not specified Not specified 1-172 10854325
DD IRAK1 Link Myd88 Co-immunoprecipitation HEK293 Human 1-215 Human Full length 11960013
DD IRAK1 Link Myd88 Co-immunoprecipitation HEK293 11976320
DD IRAK1 Link Myd88 Co-immunoprecipitation PC12 12034707
DD IRAK1 Link Myd88 Co-immunoprecipitation HEK293 Human Not specified Human Not specified 16024789
DD IRAK1 Link Myd88 Co-immunoprecipitation HEK293 Human Full length Not specified Not specified 17276401
DD IRAK1 Link Myd88 Co-immunoprecipitation HEK293 Human 2-109 Not specified Not specified 17276401
DD IRAK1 Link Myd88 Co-immunoprecipitation Rat thoracic aortas derived vascular smooth muscle cell Not specified 1-710 Not specified 1-306 17510469
DD IRAK1 Link Myd88 Co-immunoprecipitation MT2 17920759
DD IRAK1 Link Myd88 Co-immunoprecipitation HUT102 17920759
DD IRAK1 Link Myd88 Co-immunoprecipitation MT4 17920759
DD IRAK1 Link Myd88 Co-immunoprecipitation HEK293 Human 2-712 Not specified Not specified 18524972
DD IRAK1 Link Myd88 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 19679662
DD IRAK1 Link Myd88 Co-immunoprecipitation HEK293 Not specified 27-72 Not specified Not specified 19679662
DD IRAK1 Link Myd88 Co-immunoprecipitation HEK293 Not specified Not specified Not specified 27-72 19679662
DD IRAK1 Link Myd88 Co-immunoprecipitation GCB DLBCL line BAJB Not used Not specified Not specified 21179087
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Characterization
  Stoichiometry Affinity Protein-Protein interface Reference
Family DD1 DD2 Method Mutation Complex structure
DD IRAK1 Link Myd88 Co-immunoprecipitation E52A and E53A, Y58A, K95A (Myd88) 19679662
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Functional Role
Family DD1 DD2 Method Death-related Death-unrelated Reference
DD IRAK1 Link Myd88 Luciferase assay NF-kB activation 9430229
DD IRAK1 Link Myd88 Luciferase assay NF-kB-activation 19679662
(Link: click this icon to show interactions only between the two corresponding DDs)