IRAK2 / Myd88 (DD)

Interactions between IRAK2 in detail and Myd88 in detail (DD)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vitro interaction
  DD1 DD2 Reference
Family DD1 DD2 Method Species Region Expression Species Region Expression
DD IRAK2 Link Myd88 GST fusion protein pull-down Not specified Full length In vitro translation Not specified 1-296 E.coli 12659850
DD IRAK2 Link Myd88 GST fusion protein pull-down Not specified Full length In vitro translation Not specified 1-109 E.coli 12659850
DD IRAK2 Link Myd88 GST fusion protein pull-down Not specified Full length In vitro translation Not specified 1-155 E.coli 12659850
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
DD IRAK2 Link Myd88 Co-immunoprecipitation HEK293 Human Full length Human Full length 9374458
DD IRAK2 Link Myd88 Co-immunoprecipitation HEK293 Not specified Full length Not specified 1-151 10383454
DD IRAK2 Link Myd88 His fusion protein pull-down E.coli Human 1-112 Human 20-117 20485341
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Characterization
  Stoichiometry Affinity Protein-Protein interface Reference
Family DD1 DD2 Method Mutation Complex structure
DD IRAK2 Link Myd88 Structure 6:4:4 3MOP 20485341
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Functional Role
Family DD1 DD2 Method Death-related Death-unrelated Reference
DD IRAK2 Link Myd88 Luciferase assay NF-kB activation (Myddosome) 9374458
(Link: click this icon to show interactions only between the two corresponding DDs)