PIDD / RAIDD (DD)

Interactions between PIDD in detail and RAIDD in detail (DD)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vitro interaction
  DD1 DD2 Reference
Family DD1 DD2 Method Species Region Expression Species Region Expression
DD PIDD Link RAIDD In vitro purification protein assembly(Native gel-electrophoresis) Human 777-883 E.coli Human 94-199 E.coli 20406701
DD PIDD Link RAIDD In vitro purification protein assembly(Native gel-electrophoresis) Human 777-883 E.coli Human Full length E.coli 20872280
DD PIDD Link RAIDD In vitro purification protein assembly(Size-exclusion chromatography) Not specified Full length HEK293 Not specified 101-199 HEK293 15073321
DD PIDD Link RAIDD In vitro purification protein assembly(Size-exclusion chromatography) Human 777-883 E.coli Human 94-199 E.coli 17289572
DD PIDD Link RAIDD In vitro purification protein assembly(Size-exclusion chromatography) Human 777-883 E.coli Human 94-199 E.coli 17329820
DD PIDD Link RAIDD In vitro purification protein assembly(Size-exclusion chromatography) Human 777-883 E.coli Human 94-199 E.coli 20406701
DD PIDD Link RAIDD In vitro purification protein assembly(Size-exclusion chromatography) Human 777-883 E.coli Human Full length E.coli 20872280
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
DD PIDD Link RAIDD Co-Immunofluorescence staining HCT116 16652156
DD PIDD Link RAIDD Co-immunoprecipitation HEK293 Not specified Full length Not specified 101-199 15073321
DD PIDD Link RAIDD Co-immunoprecipitation Jurkat Not specified Not specified Not used 16360037
DD PIDD Link RAIDD Co-immunoprecipitation HCT116 16652156
DD PIDD Link RAIDD Co-immunoprecipitation HEK293 Not specified 588-910 Not specified Not specified 17159900
DD PIDD Link RAIDD Co-immunoprecipitation HEK293 Not specified 777-883 Human 94-199 17289572
DD PIDD Link RAIDD Co-immunoprecipitation Hippocampal CA1 subregion 18845684
DD PIDD Link RAIDD Co-immunoprecipitation HEK293 Not specified Not specified Not used 20966961
DD PIDD Link RAIDD Size-exclusion chromatography HEK293 Not specified Not specified Not used 20966961
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Characterization
  Stoichiometry Affinity Protein-Protein interface Reference
Family DD1 DD2 Method Mutation Complex structure
DD PIDD Link RAIDD Gel filtration 5:7 2OF5 17289572
DD PIDD Link RAIDD Gel filtration 7:5 2OF5 17289572
DD PIDD Link RAIDD Gel filtration 5:7 20872280
DD PIDD Link RAIDD Gel filtration 7:5 20872280
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Functional Role
Family DD1 DD2 Method Death-related Death-unrelated Reference
DD PIDD Link RAIDD Trypan blue staining Apoptosis (PIDDosome) 15073321
DD PIDD Link RAIDD Caspase cleaved assay Caspase2 activation (PIDDosome) 17159900
DD PIDD Link RAIDD TUNEL assay Apoptosis (PIDDosome) 18845684
(Link: click this icon to show interactions only between the two corresponding DDs)