RAIDD / PIDD (DD)

Interactions between RAIDD in detail and PIDD in detail (DD)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vitro interaction
  DD1 DD2 Reference
Family DD1 DD2 Method Species Region Expression Species Region Expression
DD RAIDD Link PIDD In vitro purification protein assembly(Native gel-electrophoresis) Human 94-199 E.coli Human 777-883 E.coli 20406701
DD RAIDD Link PIDD In vitro purification protein assembly(Native gel-electrophoresis) Human Full length E.coli Human 777-883 E.coli 20872280
DD RAIDD Link PIDD In vitro purification protein assembly(Size-exclusion chromatography) Not specified 101-199 HEK293 Not specified Full length HEK293 15073321
DD RAIDD Link PIDD In vitro purification protein assembly(Size-exclusion chromatography) Human 94-199 E.coli Human 777-883 E.coli 17289572
DD RAIDD Link PIDD In vitro purification protein assembly(Size-exclusion chromatography) Human 94-199 E.coli Human 777-883 E.coli 17329820
DD RAIDD Link PIDD In vitro purification protein assembly(Size-exclusion chromatography) Human 94-199 E.coli Human 777-883 E.coli 20406701
DD RAIDD Link PIDD In vitro purification protein assembly(Size-exclusion chromatography) Human Full length E.coli Human 777-883 E.coli 20872280
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
DD RAIDD Link PIDD Co-Immunofluorescence staining HCT116 16652156
DD RAIDD Link PIDD Co-immunoprecipitation HEK293 Not specified 101-199 Not specified Full length 15073321
DD RAIDD Link PIDD Co-immunoprecipitation Jurkat Not used Not specified Not specified 16360037
DD RAIDD Link PIDD Co-immunoprecipitation HCT116 16652156
DD RAIDD Link PIDD Co-immunoprecipitation HEK293 Not specified Not specified Not specified 588-910 17159900
DD RAIDD Link PIDD Co-immunoprecipitation HEK293 Human 94-199 Not specified 777-883 17289572
DD RAIDD Link PIDD Co-immunoprecipitation Hippocampal CA1 subregion 18845684
DD RAIDD Link PIDD Co-immunoprecipitation HEK293 Not used Not specified Not specified 20966961
DD RAIDD Link PIDD Size-exclusion chromatography HEK293 Not used Not specified Not specified 20966961
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Characterization
  Stoichiometry Affinity Protein-Protein interface Reference
Family DD1 DD2 Method Mutation Complex structure
DD RAIDD Link PIDD Gel filtration 5:7 2OF5 17289572
DD RAIDD Link PIDD Gel filtration 7:5 2OF5 17289572
DD RAIDD Link PIDD Gel filtration 5:7 20872280
DD RAIDD Link PIDD Gel filtration 7:5 20872280
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Functional Role
Family DD1 DD2 Method Death-related Death-unrelated Reference
DD RAIDD Link PIDD Trypan blue staining Apoptosis (PIDDosome) 15073321
DD RAIDD Link PIDD Caspase cleaved assay Caspase2 activation (PIDDosome) 17159900
DD RAIDD Link PIDD TUNEL assay Apoptosis (PIDDosome) 18845684
(Link: click this icon to show interactions only between the two corresponding DDs)