Caspase8 / FLIP (DED)

Interactions between Caspase8 in detail and FLIP in detail (DED)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vitro interaction
  DD1 DD2 Reference
Family DD1 DD2 Method Species Region Expression Species Region Expression
DED Caspase8 Link FLIP GST fusion protein pull-down Not specified 1-201 In vitro translation Human Full length Not specified 9228018
DED Caspase8 Link FLIP Yeast two-hybrid Human Full length Yeast Human 1-215 Yeast 9208847
DED Caspase8 Link FLIP Yeast two-hybrid Not specified 1-201 Yeast Human 1-160 Yeast 9228018
DED Caspase8 Link FLIP Yeast two-hybrid Not specified Not specified Yeast Human Full length Yeast 9289491
DED Caspase8 Link FLIP Yeast two-hybrid Not specified 1-480 In vitro translation Human 1-208 Not specified 9326610
DED Caspase8 Link FLIP Yeast two-hybrid Not specified 1-216 In vitro translation Human 1-180 Not specified 9326610
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
DED Caspase8 Link FLIP Co-immunoprecipitation HEK293 Not specified Not specified Human Full length 9208847
DED Caspase8 Link FLIP Co-immunoprecipitation HEK293 Not specified Not specified Human Full length 9211860
DED Caspase8 Link FLIP Co-immunoprecipitation HEK293 Not specified 1-201 Human Full length 9228018
DED Caspase8 Link FLIP Co-immunoprecipitation HEK293 Human Not specified Not specified Not specified 9380701
DED Caspase8 Link FLIP Co-immunoprecipitation Raji cell Not used Not specified Not specified 12215447
DED Caspase8 Link FLIP Co-immunoprecipitation HT1080 12887920
DED Caspase8 Link FLIP Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 12887920
DED Caspase8 Link FLIP Co-immunoprecipitation SKW6.4 17159907
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Functional Role
Family DD1 DD2 Method Death-related Death-unrelated Reference
DED Caspase8 Link FLIP β-galactosidase staining Apoptosis inhibition 9228018
DED Caspase8 Link FLIP Confocal microscopy Apoptosis inhibition 12215447
(Link: click this icon to show interactions only between the two corresponding DDs)