FLIP / Caspase8 (DED)

Interactions between FLIP in detail and Caspase8 in detail (DED)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vitro interaction
  DD1 DD2 Reference
Family DD1 DD2 Method Species Region Expression Species Region Expression
DED FLIP Link Caspase8 GST fusion protein pull-down Human Full length Not specified Not specified 1-201 In vitro translation 9228018
DED FLIP Link Caspase8 Yeast two-hybrid Human 1-215 Yeast Human Full length Yeast 9208847
DED FLIP Link Caspase8 Yeast two-hybrid Human 1-160 Yeast Not specified 1-201 Yeast 9228018
DED FLIP Link Caspase8 Yeast two-hybrid Human Full length Yeast Not specified Not specified Yeast 9289491
DED FLIP Link Caspase8 Yeast two-hybrid Human 1-208 Not specified Not specified 1-480 In vitro translation 9326610
DED FLIP Link Caspase8 Yeast two-hybrid Human 1-180 Not specified Not specified 1-216 In vitro translation 9326610
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
DED FLIP Link Caspase8 Co-immunoprecipitation HEK293 Human Full length Not specified Not specified 9208847
DED FLIP Link Caspase8 Co-immunoprecipitation HEK293 Human Full length Not specified Not specified 9211860
DED FLIP Link Caspase8 Co-immunoprecipitation HEK293 Human Full length Not specified 1-201 9228018
DED FLIP Link Caspase8 Co-immunoprecipitation HEK293 Not specified Not specified Human Not specified 9380701
DED FLIP Link Caspase8 Co-immunoprecipitation Raji cell Not specified Not specified Not used 12215447
DED FLIP Link Caspase8 Co-immunoprecipitation HT1080 12887920
DED FLIP Link Caspase8 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 12887920
DED FLIP Link Caspase8 Co-immunoprecipitation SKW6.4 17159907
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Functional Role
Family DD1 DD2 Method Death-related Death-unrelated Reference
DED FLIP Link Caspase8 β-galactosidase staining Apoptosis inhibition 9228018
DED FLIP Link Caspase8 Confocal microscopy Apoptosis inhibition 12215447
(Link: click this icon to show interactions only between the two corresponding DDs)