ASC / AIM2 (PYD)

Interactions between ASC in detail and AIM2 in detail (PYD)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vitro interaction
  DD1 DD2 Reference
Family DD1 DD2 Method Species Region Expression Species Region Expression
PYD ASC Link AIM2 GST fusion protein pull-down Human Full length Not specified Human Full length Not specified 19158676
PYD ASC Link AIM2 GST fusion protein pull-down Human Not specified Not specified Human Full length Not specified 19158676
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
PYD ASC Link AIM2 Co-immunoprecipitation HEK293 Human Not specified Human 1-83 19158675
PYD ASC Link AIM2 Co-immunoprecipitation THP-1 19158676
PYD ASC Link AIM2 Co-immunoprecipitation HMVEC-d 21575908
PYD ASC Link AIM2 Co-immunoprecipitation NPC TW02 Human Full length Human Full length 22869553
PYD ASC Link AIM2 Fluorescence resonance energy transfer HEK293 Human Not specified Human Full length 19158675
PYD ASC Link AIM2 Fluorescence resonance energy transfer HEK293 Human Not specified Human 1-83 19158675
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Functional Role
Family DD1 DD2 Method Death-related Death-unrelated Reference
PYD ASC Link AIM2 Luciferase assay NF-kB activation (Inflammasome) 19158675
PYD ASC Link AIM2 Caspase cleaved assay Caspase1 activation (Inflammasome) 19158676
(Link: click this icon to show interactions only between the two corresponding DDs)