ASC / ASC (PYD)

Interactions between ASC in detail and ASC in detail (PYD)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vitro interaction
  DD1 DD2 Reference
Family DD1 DD2 Method Species Region Expression Species Region Expression
PYD ASC Link ASC Co-immunoprecipitation Not specified Not specified HEK293 THP-1 lysate 15030775
PYD ASC Link ASC GST fusion protein pull-down Human 1-100 E.coli Human 1-100 In vitro translation 12656673
PYD ASC Link ASC GST fusion protein pull-down Not specified 1-91 E.coli Not specified 1-96 In vitro translation 23066025
PYD ASC Link ASC Yeast two-hybrid Human 1-94 Yeast Human 1-94 Yeast 19337385
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
PYD ASC Link ASC Co-immunoprecipitation COS-7 Not specified 101-195 Not specified 101-195 11162571
PYD ASC Link ASC Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 15030775
PYD ASC Link ASC Co-immunoprecipitation HEK293 Not specified 1-91 Not specified Full length 23066025
PYD ASC Link ASC Co-immunoprecipitation HEK293 Not specified 1-91 Not specified 1-96 23066025
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Characterization
  Stoichiometry Affinity Protein-Protein interface Reference
Family DD1 DD2 Method Mutation Complex structure
PYD ASC Link ASC Co-immunoprecipitation E13A, K21A, R41A, D48A, D51A (ASC) 23066025
PYD ASC Link ASC GST fusion protein pull-down E13A, K21A, R41A, D48A, D51A (ASC) 23066025
(Link: click this icon to show interactions only between the two corresponding DDs)