ASC / Pyrin (PYD)

Interactions between ASC in detail and Pyrin in detail (PYD)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vitro interaction
  DD1 DD2 Reference
Family DD1 DD2 Method Species Region Expression Species Region Expression
PYD ASC Link Pyrin His fusion protein pull-down Human Full length HEK293 Not specified Full length Sf-9 16037825
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
PYD ASC Link Pyrin Co-Immunofluorescence staining HeLa Not specified Not specified Not specified Not specified 11498534
PYD ASC Link Pyrin Co-Immunofluorescence staining PT67 Mouse Full length Mouse Full length 12667444
PYD ASC Link Pyrin Co-immunoprecipitation HEK293 Human Not specified Not specified Full length 12615073
PYD ASC Link Pyrin Co-immunoprecipitation HEK293 Human Full length Not specified Not specified 16037825
PYD ASC Link Pyrin GST fusion protein pull-down PT67 Mouse Full length Mouse Not specified 12667444
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Functional Role
Family DD1 DD2 Method Death-related Death-unrelated Reference
PYD ASC Link Pyrin DAPI staining Apoptosis inhibition 11498534
PYD ASC Link Pyrin Apoptotic DNA ladder assay Apoptosis inhibition 12667444
PYD ASC Link Pyrin β-galactosidase staining, Luciferase assay Apoptosis inhibition NLRP3-ASC mediated NF-kB activation block 12615073
PYD ASC Link Pyrin Caspase cleaved assay Caspase1 activation (Inflammasome) 16037825
(Link: click this icon to show interactions only between the two corresponding DDs)