NLRP2 / ASC (PYD)

Interactions between NLRP2 in detail and ASC in detail (PYD)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vitro interaction
  DD1 DD2 Reference
Family DD1 DD2 Method Species Region Expression Species Region Expression
PYD NLRP2 Link ASC Co-immunoprecipitation Human 1-93 HEK293 THP-1 lysate 15030775
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
PYD NLRP2 Link ASC Co-immunoprecipitation HEK293 Human 1-93 Not specified Not specified 15030775
PYD NLRP2 Link ASC Co-immunoprecipitation THP-1 Human Full length Not used 15030775
PYD NLRP2 Link ASC Co-immunoprecipitation HEK293 Not specified Full length Not specified Full length 15456791
PYD NLRP2 Link ASC Co-immunoprecipitation HEK293 Not specified Full length Not specified Not specified 15456791
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Characterization
  Stoichiometry Affinity Protein-Protein interface Reference
Family DD1 DD2 Method Mutation Complex structure
PYD NLRP2 Link ASC Co-immunoprecipitation E13W (ASC) 15456791
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Functional Role
Family DD1 DD2 Method Death-related Death-unrelated Reference
PYD NLRP2 Link ASC ELISA IL-1b secretion (Inflammasome) 15456791
(Link: click this icon to show interactions only between the two corresponding DDs)