Pyrin / ASC (PYD)

Interactions between Pyrin in detail and ASC in detail (PYD)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vitro interaction
  DD1 DD2 Reference
Family DD1 DD2 Method Species Region Expression Species Region Expression
PYD Pyrin Link ASC His fusion protein pull-down Not specified Full length Sf-9 Human Full length HEK293 16037825
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
PYD Pyrin Link ASC Co-Immunofluorescence staining HeLa Not specified Not specified Not specified Not specified 11498534
PYD Pyrin Link ASC Co-Immunofluorescence staining PT67 Mouse Full length Mouse Full length 12667444
PYD Pyrin Link ASC Co-immunoprecipitation HEK293 Not specified Full length Human Not specified 12615073
PYD Pyrin Link ASC Co-immunoprecipitation HEK293 Not specified Not specified Human Full length 16037825
PYD Pyrin Link ASC GST fusion protein pull-down PT67 Mouse Not specified Mouse Full length 12667444
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Functional Role
Family DD1 DD2 Method Death-related Death-unrelated Reference
PYD Pyrin Link ASC DAPI staining Apoptosis inhibition 11498534
PYD Pyrin Link ASC Apoptotic DNA ladder assay Apoptosis inhibition 12667444
PYD Pyrin Link ASC β-galactosidase staining, Luciferase assay Apoptosis inhibition NLRP3-ASC mediated NF-kB activation block 12615073
PYD Pyrin Link ASC Caspase cleaved assay Caspase1 activation (Inflammasome) 16037825
(Link: click this icon to show interactions only between the two corresponding DDs)