DD

Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vitro interaction
  DD1 DD2 Reference
Family DD1 DD2 Method Species Region Expression Species Region Expression
DD ANK3 Link FADD GST fusion protein pull-down Rat Not specified Not specified Not specified Not specified Not specified 14694156
DD ANK3 Link Fas GST fusion protein pull-down Rat Not specified Not specified Not specified Not specified Not specified 14694156
DD ANK3 Link Fas Yeast two-hybrid Rat Not specified Yeast Not specified Not specified Yeast 14694156
DD DR3 Link DR3 Yeast two-hybrid Not specified Not specified Yeast Not specified Not specified Yeast 8934525
DD DR3 Link TNFR1 Yeast two-hybrid Not specified Not specified Yeast Human Not specified Yeast 8934525
DD DR3 Link TRADD GST fusion protein pull-down Human 215-393 E.coli Not specified Not specified In vitro translation 8875942
DD DR4 Link DR5 Affinity purification-mass spectrometry H460cell lyaste H460cell lyaste 19427028
DD DR4 Link FADD Affinity purification-mass spectrometry H460cell lyaste H460cell lyaste 19427028
DD DR4 Link FADD GST fusion protein pull-down Not specified 269-468 E.coli HeLa lysate 12920112
DD DR4 Link FADD Yeast two-hybrid Not specified 272-469 Yeast Not specified Full length Yeast 15452120
DD DR5 Link DR4 Affinity purification-mass spectrometry H460cell lyaste H460cell lyaste 19427028
DD DR5 Link FADD GST fusion protein pull-down Not specified 191-411 E.coli Jurkat lysate 12721308
DD DR5 Link FADD GST fusion protein pull-down Not specified 209-411 E.coli HeLa lysate 12920112
DD DR5 Link FADD Yeast two-hybrid Not specified 209-412 Yeast Not specified Full length Yeast 15173180
DD DR5 Link FADD Yeast two-hybrid Not specified 209-412 Yeast Not specified Full length Yeast 15452120
DD EDAR Link EDARADD GST fusion protein pull-down Not specified 212-448 E.coli Human Not specified In vitro translation 11780064
DD EDARADD Link EDAR GST fusion protein pull-down Human Not specified In vitro translation Not specified 212-448 E.coli 11780064
DD EDARADD Link EDARADD GST fusion protein pull-down Human Not specified In vitro translation Human Not specified E.coli 11780064
DD FADD Link ANK3 GST fusion protein pull-down Not specified Not specified Not specified Rat Not specified Not specified 14694156
DD FADD Link DR4 Affinity purification-mass spectrometry H460cell lyaste H460cell lyaste 19427028
DD FADD Link DR4 GST fusion protein pull-down HeLa lysate Not specified 269-468 E.coli 12920112
DD FADD Link DR4 Yeast two-hybrid Not specified Full length Yeast Not specified 272-469 Yeast 15452120
DD FADD Link DR5 GST fusion protein pull-down Jurkat lysate Not specified 191-411 E.coli 12721308
DD FADD Link DR5 GST fusion protein pull-down HeLa lysate Not specified 209-411 E.coli 12920112
DD FADD Link DR5 Yeast two-hybrid Not specified Full length Yeast Not specified 209-412 Yeast 15173180
DD FADD Link DR5 Yeast two-hybrid Not specified Full length Yeast Not specified 209-412 Yeast 15452120
DD FADD Link Fas Affinity purification-mass spectrometry Human 93-184 E.coli Mouse 210-310 E.coli 20935634
DD FADD Link Fas Affinity purification-mass spectrometry Human 93-191 E.coli Human 218-318 E.coli 20935634
DD FADD Link Fas GST fusion protein pull-down Not specified Not specified Not specified Human 175-319 Not specified 7536190
DD FADD Link Fas GST fusion protein pull-down Not specified Not specified Yeast Not specified Not specified Yeast 7538907
DD FADD Link Fas GST fusion protein pull-down Not specified Not specified In vitro translation Not specified Not specified E.coli 8875942
DD FADD Link Fas GST fusion protein pull-down Human 80-205 In vitro translation Murine 165-295 Not specified 9990010
DD FADD Link Fas GST fusion protein pull-down Not specified Not specified In vitro translation Human 174-319 E.coli 10200300
DD FADD Link Fas GST fusion protein pull-down Jurkat lysate Not specified 191-335 E.coli 12721308
DD FADD Link Fas GST fusion protein pull-down Human Full length In vitro translation Human Not specified Not specified 14573612
DD FADD Link Fas His fusion protein pull-down Human 93-208 E.coli Human 223-335 E.coli 19118384
DD FADD Link Fas His fusion protein pull-down Not specified Not specified E.coli Not specified Not specified E.coli 20935634
DD FADD Link Fas In vitro purification protein assembly(Pull down) Not specified Not specified HEK293 Not specified 1-304 E.coli 7538907
DD FADD Link Fas In vitro purification protein assembly(Size-exclusion chromatography) Human 93-208 E.coli Human 223-335 E.coli 19118384
DD FADD Link Fas In vitro purification protein assembly(Size-exclusion chromatography) Human 93-184 E.coli Human 210-310 E.coli 20935634
DD FADD Link Fas In vitro purification protein assembly(Surface plasmon resonance) Not specified 89-183 E.coli Human Not specified E.coli 10347191
DD FADD Link Fas Yeast two-hybrid Not specified 130-245 Yeast Human 175-319 Yeast 7536190
DD FADD Link Fas Yeast two-hybrid Not specified 130-245 Yeast Human 200-319 Yeast 7536190
DD FADD Link Fas Yeast two-hybrid Not specified Not specified In vitro translation Not specified 1-304 E.coli 7538907
DD FADD Link Fas Yeast two-hybrid Not specified 92-208 Yeast Not specified 210-319 Yeast 8642271
DD FADD Link Fas Yeast two-hybrid Human 80-208 Yeast Human 177-335 Yeast 11464214
DD FADD Link Fas Yeast two-hybrid Not specified Full length Yeast Human 191-313 Yeast 12107169
DD FADD Link Fas Yeast two-hybrid Not specified Not specified Yeast Not specified 177-335 Yeast 15173180
DD FADD Link RIP Yeast two-hybrid Not specified 92-208 Yeast Not specified 261-372 Yeast 8642271
DD FADD Link RIP Yeast two-hybrid Human Full length Yeast Human 580-671 Yeast 10755617
DD FADD Link RIP Yeast two-hybrid Human 80-208 Yeast Human Full length Yeast 11464214
DD FADD Link RIP1 GST fusion protein pull-down Human 93-184 E.coli Not specified 583-663 E.coli 22922561
DD FADD Link RIP1 In vitro purification protein assembly(Size-exclusion chromatography) Human 93-184 E.coli Not specified 583-663 E.coli 22922561
DD FADD Link RIP1 In vitro purification protein assembly(Surface plasmon resonance) Human 93-184 E.coli Not specified 583-663 E.coli 22922561
DD FADD Link TNFR1 Yeast two-hybrid Not specified 92-208 Yeast Not specified 326-426 Yeast 8642271
DD FADD Link TRADD GST fusion protein pull-down Not specified Full length E.coli Not specified 243-455 In vitro translation 16006552
DD FADD Link TRADD Yeast two-hybrid Not specified Full length Yeast Not specified Full length Yeast 8565075
DD FADD Link TRADD Yeast two-hybrid Not specified Full length Yeast Not specified 55-312 Yeast 8565075
DD FADD Link TRADD Yeast two-hybrid Not specified Full length Yeast Not specified 195-312 Yeast 8565075
DD FADD Link TRADD Yeast two-hybrid Not specified 92-208 Yeast Not specified 195-312 Yeast 8642271
DD FADD Link TRADD Yeast two-hybrid Human 80-208 Yeast Human Full length Yeast 11464214
DD FADD Link TRADD Yeast two-hybrid Not specified Full length Yeast Not specified Full length Yeast 12107169
DD Fas Link ANK3 GST fusion protein pull-down Not specified Not specified Not specified Rat Not specified Not specified 14694156
DD Fas Link ANK3 Yeast two-hybrid Not specified Not specified Yeast Rat Not specified Yeast 14694156
DD Fas Link FADD Affinity purification-mass spectrometry Mouse 210-310 E.coli Human 93-184 E.coli 20935634
DD Fas Link FADD Affinity purification-mass spectrometry Human 218-318 E.coli Human 93-191 E.coli 20935634
DD Fas Link FADD GST fusion protein pull-down Human 175-319 Not specified Not specified Not specified Not specified 7536190
DD Fas Link FADD GST fusion protein pull-down Not specified Not specified Yeast Not specified Not specified Yeast 7538907
DD Fas Link FADD GST fusion protein pull-down Not specified Not specified E.coli Not specified Not specified In vitro translation 8875942
DD Fas Link FADD GST fusion protein pull-down Murine 165-295 Not specified Human 80-205 In vitro translation 9990010
DD Fas Link FADD GST fusion protein pull-down Human 174-319 E.coli Not specified Not specified In vitro translation 10200300
DD Fas Link FADD GST fusion protein pull-down Not specified 191-335 E.coli Jurkat lysate 12721308
DD Fas Link FADD GST fusion protein pull-down Human Not specified Not specified Human Full length In vitro translation 14573612
DD Fas Link FADD His fusion protein pull-down Human 223-335 E.coli Human 93-208 E.coli 19118384
DD Fas Link FADD His fusion protein pull-down Not specified Not specified E.coli Not specified Not specified E.coli 20935634
DD Fas Link FADD In vitro purification protein assembly(Pull down) Not specified 1-304 E.coli Not specified Not specified HEK293 7538907
DD Fas Link FADD In vitro purification protein assembly(Size-exclusion chromatography) Human 223-335 E.coli Human 93-208 E.coli 19118384
DD Fas Link FADD In vitro purification protein assembly(Size-exclusion chromatography) Human 210-310 E.coli Human 93-184 E.coli 20935634
DD Fas Link FADD In vitro purification protein assembly(Surface plasmon resonance) Human Not specified E.coli Not specified 89-183 E.coli 10347191
DD Fas Link FADD Yeast two-hybrid Human 175-319 Yeast Not specified 130-245 Yeast 7536190
DD Fas Link FADD Yeast two-hybrid Human 200-319 Yeast Not specified 130-245 Yeast 7536190
DD Fas Link FADD Yeast two-hybrid Not specified 1-304 E.coli Not specified Not specified In vitro translation 7538907
DD Fas Link FADD Yeast two-hybrid Not specified 210-319 Yeast Not specified 92-208 Yeast 8642271
DD Fas Link FADD Yeast two-hybrid Human 177-335 Yeast Human 80-208 Yeast 11464214
DD Fas Link FADD Yeast two-hybrid Human 191-313 Yeast Not specified Full length Yeast 12107169
DD Fas Link FADD Yeast two-hybrid Not specified 177-335 Yeast Not specified Not specified Yeast 15173180
DD Fas Link Fas Yeast two-hybrid Human 175-319 Yeast Human 175-319 Yeast 7536190
DD Fas Link Fas Yeast two-hybrid Human 192-329 Yeast Human Full length Yeast 7538908
DD Fas Link Fas Yeast two-hybrid Not specified 210-319 Yeast Not specified 210-319 Yeast 8642271
DD Fas Link RIP Yeast two-hybrid Human 192-329 Yeast Human Full length Yeast 7538908
DD Fas Link RIP Yeast two-hybrid Not specified 210-319 Yeast Not specified 261-372 Yeast 8642271
DD IRAK2 Link Myd88 GST fusion protein pull-down Not specified Full length In vitro translation Not specified 1-296 E.coli 12659850
DD IRAK2 Link Myd88 GST fusion protein pull-down Not specified Full length In vitro translation Not specified 1-109 E.coli 12659850
DD IRAK2 Link Myd88 GST fusion protein pull-down Not specified Full length In vitro translation Not specified 1-155 E.coli 12659850
DD IRAK4 Link Myd88 His fusion protein pull-down Human 1-185 E.coli Human 1-157 E.coli 19167362
DD IRAK4 Link Myd88 In vitro purification protein assembly(chemical crosslinking) Human 1-152 E.coli Human 1-110 E.coli 19592493
DD IRAK4 Link Myd88 In vitro purification protein assembly(Size-exclusion chromatography) Human 1-152 E.coli Human 1-110 E.coli 19592493
DD IRAK4 Link Myd88 In vitro purification protein assembly(Size-exclusion chromatography) Human 1-117 E.coli Human 1-157 E.coli 20966070
DD IRAK4 Link Myd88 Yeast two-hybrid Not specified Full length Yeast Not specified Full length Yeast 12538665
DD IRAK4 Link Myd88 Yeast two-hybrid Not specified Full length Yeast Not specified 1-172 Yeast 12538665
DD MADD Link MADD Yeast two-hybrid Not specified 1281-1356 Yeast Not specified 1281-1356 Yeast 9115275
DD MADD Link TNFR1 GST fusion protein pull-down Not specified 982-1588 Not specified Not specified 326-413 Not specified 9115275
DD MADD Link TNFR1 Yeast two-hybrid Not specified 982-1588 Yeast Not specified 326-413 Yeast 9115275
DD MADD Link TNFR1 Yeast two-hybrid Not specified 1281-1356 Yeast Not specified 326-413 Yeast 9115275
DD MADD Link TRADD Yeast two-hybrid Not specified 1281-1356 Yeast Not specified 222-289 Yeast 9115275
DD Myd88 Link IRAK2 GST fusion protein pull-down Not specified 1-296 E.coli Not specified Full length In vitro translation 12659850
DD Myd88 Link IRAK2 GST fusion protein pull-down Not specified 1-109 E.coli Not specified Full length In vitro translation 12659850
DD Myd88 Link IRAK2 GST fusion protein pull-down Not specified 1-155 E.coli Not specified Full length In vitro translation 12659850
DD Myd88 Link IRAK4 His fusion protein pull-down Human 1-157 E.coli Human 1-185 E.coli 19167362
DD Myd88 Link IRAK4 In vitro purification protein assembly(chemical crosslinking) Human 1-110 E.coli Human 1-152 E.coli 19592493
DD Myd88 Link IRAK4 In vitro purification protein assembly(Size-exclusion chromatography) Human 1-110 E.coli Human 1-152 E.coli 19592493
DD Myd88 Link IRAK4 In vitro purification protein assembly(Size-exclusion chromatography) Human 1-157 E.coli Human 1-117 E.coli 20966070
DD Myd88 Link IRAK4 Yeast two-hybrid Not specified Full length Yeast Not specified Full length Yeast 12538665
DD Myd88 Link IRAK4 Yeast two-hybrid Not specified 1-172 Yeast Not specified Full length Yeast 12538665
DD Myd88 Link Myd88 GST fusion protein pull-down Mouse Full length Not specified Mouse Full length In vitro translation 9575168
DD Myd88 Link Myd88 Yeast two-hybrid Mouse Full length Yeast Mouse Full length Yeast 9575168
DD Myd88 Link Myd88 Yeast two-hybrid Not specified Full length Yeast Not specified Full length Yeast 11544529
DD NF-kB1 Link NF-kB2 Affinity purification-mass spectrometry HEK293 lysate HEK293 lysate 14743216
DD NF-kB2 Link NF-kB1 Affinity purification-mass spectrometry HEK293 lysate HEK293 lysate 14743216
DD PIDD Link RAIDD In vitro purification protein assembly(Native gel-electrophoresis) Human 777-883 E.coli Human 94-199 E.coli 20406701
DD PIDD Link RAIDD In vitro purification protein assembly(Native gel-electrophoresis) Human 777-883 E.coli Human Full length E.coli 20872280
DD PIDD Link RAIDD In vitro purification protein assembly(Size-exclusion chromatography) Not specified Full length HEK293 Not specified 101-199 HEK293 15073321
DD PIDD Link RAIDD In vitro purification protein assembly(Size-exclusion chromatography) Human 777-883 E.coli Human 94-199 E.coli 17289572
DD PIDD Link RAIDD In vitro purification protein assembly(Size-exclusion chromatography) Human 777-883 E.coli Human 94-199 E.coli 17329820
DD PIDD Link RAIDD In vitro purification protein assembly(Size-exclusion chromatography) Human 777-883 E.coli Human 94-199 E.coli 20406701
DD PIDD Link RAIDD In vitro purification protein assembly(Size-exclusion chromatography) Human 777-883 E.coli Human Full length E.coli 20872280
DD RAIDD Link PIDD In vitro purification protein assembly(Native gel-electrophoresis) Human 94-199 E.coli Human 777-883 E.coli 20406701
DD RAIDD Link PIDD In vitro purification protein assembly(Native gel-electrophoresis) Human Full length E.coli Human 777-883 E.coli 20872280
DD RAIDD Link PIDD In vitro purification protein assembly(Size-exclusion chromatography) Not specified 101-199 HEK293 Not specified Full length HEK293 15073321
DD RAIDD Link PIDD In vitro purification protein assembly(Size-exclusion chromatography) Human 94-199 E.coli Human 777-883 E.coli 17289572
DD RAIDD Link PIDD In vitro purification protein assembly(Size-exclusion chromatography) Human 94-199 E.coli Human 777-883 E.coli 17329820
DD RAIDD Link PIDD In vitro purification protein assembly(Size-exclusion chromatography) Human 94-199 E.coli Human 777-883 E.coli 20406701
DD RAIDD Link PIDD In vitro purification protein assembly(Size-exclusion chromatography) Human Full length E.coli Human 777-883 E.coli 20872280
DD RAIDD Link RIP GST fusion protein pull-down Human Not specified E.coli Human Not specified In vitro translation 9044836
DD RIP Link FADD Yeast two-hybrid Not specified 261-372 Yeast Not specified 92-208 Yeast 8642271
DD RIP Link FADD Yeast two-hybrid Human 580-671 Yeast Human Full length Yeast 10755617
DD RIP Link FADD Yeast two-hybrid Human Full length Yeast Human 80-208 Yeast 11464214
DD RIP Link Fas Yeast two-hybrid Human Full length Yeast Human 192-329 Yeast 7538908
DD RIP Link Fas Yeast two-hybrid Not specified 261-372 Yeast Not specified 210-319 Yeast 8642271
DD RIP Link RAIDD GST fusion protein pull-down Human Not specified In vitro translation Human Not specified E.coli 9044836
DD RIP Link RIP Yeast two-hybrid Not specified 261-372 Yeast Not specified 261-372 Yeast 8642271
DD RIP Link RIP Yeast two-hybrid Human 580-671 Yeast Human Full length Yeast 10755617
DD RIP Link TNFR1 GST fusion protein pull-down Jurkat lysate Not specified 237-455 E.coli 12721308
DD RIP Link TNFR1 Yeast two-hybrid Not specified 261-372 Yeast Not specified 326-426 Yeast 8642271
DD RIP Link TRADD Yeast two-hybrid Not specified 261-372 Yeast Not specified 195-312 Yeast 8642271
DD RIP Link TRADD Yeast two-hybrid Human 580-671 Yeast Human Full length Yeast 10755617
DD RIP1 Link FADD GST fusion protein pull-down Not specified 583-663 E.coli Human 93-184 E.coli 22922561
DD RIP1 Link FADD In vitro purification protein assembly(Size-exclusion chromatography) Not specified 583-663 E.coli Human 93-184 E.coli 22922561
DD RIP1 Link FADD In vitro purification protein assembly(Surface plasmon resonance) Not specified 583-663 E.coli Human 93-184 E.coli 22922561
DD TNFR1 Link DR3 Yeast two-hybrid Human Not specified Yeast Not specified Not specified Yeast 8934525
DD TNFR1 Link FADD Yeast two-hybrid Not specified 326-426 Yeast Not specified 92-208 Yeast 8642271
DD TNFR1 Link MADD GST fusion protein pull-down Not specified 326-413 Not specified Not specified 982-1588 Not specified 9115275
DD TNFR1 Link MADD Yeast two-hybrid Not specified 326-413 Yeast Not specified 982-1588 Yeast 9115275
DD TNFR1 Link MADD Yeast two-hybrid Not specified 326-413 Yeast Not specified 1281-1356 Yeast 9115275
DD TNFR1 Link RIP GST fusion protein pull-down Not specified 237-455 E.coli Jurkat lysate 12721308
DD TNFR1 Link RIP Yeast two-hybrid Not specified 326-426 Yeast Not specified 261-372 Yeast 8642271
DD TNFR1 Link TNFR1 GST fusion protein pull-down Human 206-426 Not specified Human 206-426 Not specified 7529234
DD TNFR1 Link TNFR1 GST fusion protein pull-down Not specified 326-426 E.coli Not specified 214-455 E.coli 11231290
DD TNFR1 Link TNFR1 Yeast two-hybrid Human 206-426 Yeast Human 206-426 Yeast 7529234
DD TNFR1 Link TNFR1 Yeast two-hybrid Human 206-426 Yeast Human 328-426 Yeast 7529234
DD TNFR1 Link TNFR1 Yeast two-hybrid Not specified 204-426 Yeast Not specified 204-426 Yeast 8077196
DD TNFR1 Link TNFR1 Yeast two-hybrid Not specified 204-426 Yeast Not specified 329-426 Yeast 8077196
DD TNFR1 Link TNFR1 Yeast two-hybrid Not specified 326-426 Yeast Not specified 326-426 Yeast 8642271
DD TNFR1 Link TRADD GST fusion protein pull-down Human Not specified Not specified Human Full length In vitro translation 7758105
DD TNFR1 Link TRADD GST fusion protein pull-down Human Not specified Not specified Human 1-305 In vitro translation 7758105
DD TNFR1 Link TRADD GST fusion protein pull-down Human Not specified Not specified Human 195-312 In vitro translation 7758105
DD TNFR1 Link TRADD GST fusion protein pull-down Human 214-426 Not specified Human 196-312 In vitro translation 8621670
DD TNFR1 Link TRADD GST fusion protein pull-down Not specified Not specified E.coli Not specified Not specified In vitro translation 8875942
DD TNFR1 Link TRADD GST fusion protein pull-down Not specified 326-426 E.coli Not specified Not specified E.coli 11231290
DD TNFR1 Link TRADD GST fusion protein pull-down Not specified 237-455 E.coli Jurkat lysate 12721308
DD TNFR1 Link TRADD GST fusion protein pull-down Not specified 195-312 E.coli Not specified 243-455 In vitro translation 16006552
DD TNFR1 Link TRADD Yeast two-hybrid Human 214-426 Yeast Human Full length Yeast 7758105
DD TNFR1 Link TRADD Yeast two-hybrid Not specified 326-426 Yeast Not specified 195-312 Yeast 8642271
DD TRADD Link DR3 GST fusion protein pull-down Not specified Not specified In vitro translation Human 215-393 E.coli 8875942
DD TRADD Link FADD GST fusion protein pull-down Not specified 243-455 In vitro translation Not specified Full length E.coli 16006552
DD TRADD Link FADD Yeast two-hybrid Not specified Full length Yeast Not specified Full length Yeast 8565075
DD TRADD Link FADD Yeast two-hybrid Not specified 55-312 Yeast Not specified Full length Yeast 8565075
DD TRADD Link FADD Yeast two-hybrid Not specified 195-312 Yeast Not specified Full length Yeast 8565075
DD TRADD Link FADD Yeast two-hybrid Not specified 195-312 Yeast Not specified 92-208 Yeast 8642271
DD TRADD Link FADD Yeast two-hybrid Human Full length Yeast Human 80-208 Yeast 11464214
DD TRADD Link FADD Yeast two-hybrid Not specified Full length Yeast Not specified Full length Yeast 12107169
DD TRADD Link MADD Yeast two-hybrid Not specified 222-289 Yeast Not specified 1281-1356 Yeast 9115275
DD TRADD Link RIP Yeast two-hybrid Not specified 195-312 Yeast Not specified 261-372 Yeast 8642271
DD TRADD Link RIP Yeast two-hybrid Human Full length Yeast Human 580-671 Yeast 10755617
DD TRADD Link TNFR1 GST fusion protein pull-down Human Full length In vitro translation Human Not specified Not specified 7758105
DD TRADD Link TNFR1 GST fusion protein pull-down Human 1-305 In vitro translation Human Not specified Not specified 7758105
DD TRADD Link TNFR1 GST fusion protein pull-down Human 195-312 In vitro translation Human Not specified Not specified 7758105
DD TRADD Link TNFR1 GST fusion protein pull-down Human 196-312 In vitro translation Human 214-426 Not specified 8621670
DD TRADD Link TNFR1 GST fusion protein pull-down Not specified Not specified In vitro translation Not specified Not specified E.coli 8875942
DD TRADD Link TNFR1 GST fusion protein pull-down Not specified Not specified E.coli Not specified 326-426 E.coli 11231290
DD TRADD Link TNFR1 GST fusion protein pull-down Jurkat lysate Not specified 237-455 E.coli 12721308
DD TRADD Link TNFR1 GST fusion protein pull-down Not specified 243-455 In vitro translation Not specified 195-312 E.coli 16006552
DD TRADD Link TNFR1 Yeast two-hybrid Human Full length Yeast Human 214-426 Yeast 7758105
DD TRADD Link TNFR1 Yeast two-hybrid Not specified 195-312 Yeast Not specified 326-426 Yeast 8642271
DD TRADD Link TRADD GST fusion protein pull-down Human 196-312 In vitro translation Human 214-426 Not specified 8621670
DD TRADD Link TRADD Yeast two-hybrid Not specified 195-312 Yeast Not specified 195-312 Yeast 8642271
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
DD ANK3 Link FADD Co-Immunofluorescence staining MDCK Rat Not specified Not specified Not specified 14694156
DD ANK3 Link FADD Co-immunoprecipitation MDCK Rat Not specified Not specified Not specified 14694156
DD ANK3 Link Fas Co-Immunofluorescence staining MDCK Rat Not specified Not specified Not specified 14694156
DD ANK3 Link Fas Co-immunoprecipitation MDCK Rat Not specified Not specified Not specified 14694156
DD DAPK1 Link FADD Co-Immunofluorescence staining Rat brain cell 12911633
DD DAPK1 Link FADD Co-immunoprecipitation Rat brain cell 12911633
DD DAPK1 Link FADD Co-immunoprecipitation Human Epilepsy brain lysate 15048887
DD DAPK1 Link FADD Co-immunoprecipitation MBA-MB-231 21168190
DD DAPK1 Link TNFR1 Co-Immunofluorescence staining Rat brain cell 12911633
DD DAPK1 Link TNFR1 Co-immunoprecipitation Rat brain cell 12911633
DD DAPK1 Link UNC5B Co-immunoprecipitation HEK293 Not specified Full length Not specified Full length 15729359
DD DAPK1 Link UNC5B Co-immunoprecipitation HEK293 Not specified Full length Not specified Not specified 15729359
DD DAPK1 Link UNC5B Co-immunoprecipitation HEK293 Not specified Full length Not specified 841-945 15729359
DD DAPK1 Link UNC5B Co-immunoprecipitation HEK293 Not specified Full length Not specified 631-945 15729359
DD DAPK1 Link UNC5B Co-immunoprecipitation HEK293 Not specified 1301-1431 Not specified Full length 15729359
DD DR3 Link DR3 Co-immunoprecipitation HEK293 Human 332-413 Human 332-413 9052839
DD DR3 Link FADD Co-immunoprecipitation HEK293 Human 332-413 Not specified Not specified 9052839
DD DR3 Link FADD Co-immunoprecipitation HEK293 Human 27-418 Human Not specified 9430227
DD DR3 Link TRADD Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 8934525
DD DR3 Link TRADD Co-immunoprecipitation HEK293 Human Not specified Not specified Not specified 9430227
DD DR3 Link TRADD Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 9714541
DD DR4 Link DR5 Co-immunoprecipitation HeLa 16980609
DD DR4 Link FADD Co-immunoprecipitation HEK293 Human 106-468 Human Not specified 9430227
DD DR4 Link FADD Co-immunoprecipitation HEK293 Not specified 261-465 Not specified 80-208 9430228
DD DR4 Link FADD Co-immunoprecipitation BAJB Not specified 272-469 Not specified Full length 15452120
DD DR4 Link FADD Co-immunoprecipitation HeLa 16980609
DD DR4 Link FADD Co-immunoprecipitation SW948 21272366
DD DR4 Link MADD Co-immunoprecipitation HEK293 Not specified Not specified Human Full length 15208670
DD DR4 Link MADD Co-immunoprecipitation HEK293 Not specified Not specified Human 628-1376 15208670
DD DR4 Link MADD Fluorescence resonance energy transfer HeLa Not specified Not specified Human Full length 15208670
DD DR4 Link RIP Co-immunoprecipitation HEK293 Human 1-351 Human 559-671 10958661
DD DR4 Link RIP His fusion protein pull-down HEK293 Human 106-468 Human Not specified 9430227
DD DR4 Link TRADD Co-immunoprecipitation HEK293 Human 106-468 Human 121-312 9430227
DD DR4 Link TRADD Co-immunoprecipitation HEK293 Not specified 261-465 Not specified Not specified 9430228
DD DR5 Link DR4 Co-immunoprecipitation HeLa 16980609
DD DR5 Link DR5 Size-exclusion chromatography HeLa 17585340
DD DR5 Link FADD Co-immunoprecipitation HEK293 Human 51-411 Human Not specified 9430227
DD DR5 Link FADD Co-immunoprecipitation HEK293 Not specified 232-439 Not specified 80-208 9430228
DD DR5 Link FADD Co-immunoprecipitation BJAB 15173180
DD DR5 Link FADD Co-immunoprecipitation HeLa Not specified 79-208 Not specified 272-469 15173180
DD DR5 Link FADD Co-immunoprecipitation BJAB Not specified 209-412 Not specified Full length 15452120
DD DR5 Link FADD Co-immunoprecipitation HepG2 16980609
DD DR5 Link FADD Co-immunoprecipitation HeLa 17585340
DD DR5 Link FADD Co-immunoprecipitation SW948 21272366
DD DR5 Link MADD Co-immunoprecipitation HEK293 Not specified Not specified Human Full length 15208670
DD DR5 Link MADD Co-immunoprecipitation HEK293 Not specified Not specified Human 628-1376 15208670
DD DR5 Link RIP Co-immunoprecipitation HEK293 Human 51-411 Human Not specified 9430227
DD DR5 Link TRADD Co-immunoprecipitation HEK293 Human 51-411 Human 121-312 9430227
DD DR5 Link TRADD Co-immunoprecipitation HEK293 Not specified 261-465 Not specified Not specified 9430228
DD DR5 Link TRADD Co-immunoprecipitation HEK293 Not specified 232-439 Not specified Not specified 9430228
DD DR6 Link TRADD Co-immunoprecipitation HEK293 Not specified 42-655 Not specified Not specified 9714541
DD EDAR Link EDARADD Co-immunoprecipitation HEK293 Not specified 212-448 Human Not specified 11780064
DD EDAR Link EDARADD Co-immunoprecipitation HEK293 Mouse Full length Human Not specified 17354266
DD EDAR Link EDARADD Co-immunoprecipitation HEK293 Not specified Not specified Human Not specified 20222921
DD EDARADD Link EDAR Co-immunoprecipitation HEK293 Human Not specified Not specified 212-448 11780064
DD EDARADD Link EDAR Co-immunoprecipitation HEK293 Human Not specified Mouse Full length 17354266
DD EDARADD Link EDAR Co-immunoprecipitation HEK293 Human Not specified Not specified Not specified 20222921
DD EDARADD Link EDARADD Co-immunoprecipitation HEK293 Human Not specified Human Not specified 11780064
DD EDARADD Link EDARADD Co-immunoprecipitation HEK293 Human Not specified Human Not specified 17354266
DD FADD Link ANK3 Co-Immunofluorescence staining MDCK Not specified Not specified Rat Not specified 14694156
DD FADD Link ANK3 Co-immunoprecipitation MDCK Not specified Not specified Rat Not specified 14694156
DD FADD Link DAPK1 Co-Immunofluorescence staining Rat brain cell 12911633
DD FADD Link DAPK1 Co-immunoprecipitation Rat brain cell 12911633
DD FADD Link DAPK1 Co-immunoprecipitation Human Epilepsy brain lysate 15048887
DD FADD Link DAPK1 Co-immunoprecipitation MBA-MB-231 21168190
DD FADD Link DR3 Co-immunoprecipitation HEK293 Not specified Not specified Human 332-413 9052839
DD FADD Link DR3 Co-immunoprecipitation HEK293 Human Not specified Human 27-418 9430227
DD FADD Link DR4 Co-immunoprecipitation HEK293 Human Not specified Human 106-468 9430227
DD FADD Link DR4 Co-immunoprecipitation HEK293 Not specified 80-208 Not specified 261-465 9430228
DD FADD Link DR4 Co-immunoprecipitation BAJB Not specified Full length Not specified 272-469 15452120
DD FADD Link DR4 Co-immunoprecipitation HeLa 16980609
DD FADD Link DR4 Co-immunoprecipitation SW948 21272366
DD FADD Link DR5 Co-immunoprecipitation HEK293 Human Not specified Human 51-411 9430227
DD FADD Link DR5 Co-immunoprecipitation HEK293 Not specified 80-208 Not specified 232-439 9430228
DD FADD Link DR5 Co-immunoprecipitation BJAB 15173180
DD FADD Link DR5 Co-immunoprecipitation HeLa Not specified 272-469 Not specified 79-208 15173180
DD FADD Link DR5 Co-immunoprecipitation BJAB Not specified Full length Not specified 209-412 15452120
DD FADD Link DR5 Co-immunoprecipitation HepG2 16980609
DD FADD Link DR5 Co-immunoprecipitation HeLa 17585340
DD FADD Link DR5 Co-immunoprecipitation SW948 21272366
DD FADD Link Fas Jurkat 21557211
DD FADD Link Fas Co-Immunofluorescence staining Jurkat 12702723
DD FADD Link Fas Co-Immunofluorescence staining BJAB Not specified Not specified Not specified Not specified 16498403
DD FADD Link Fas Co-immunoprecipitation HeLa Not specified Not specified Not specified Not specified 7536190
DD FADD Link Fas Co-immunoprecipitation HEK293 Not specified Not specified Not specified 1-304 7538907
DD FADD Link Fas Co-immunoprecipitation HEK293 Not specified 80-208 Not specified Not specified 8617770
DD FADD Link Fas Co-immunoprecipitation HEK293 Not specified 2-208 Not specified Not specified 8617770
DD FADD Link Fas Co-immunoprecipitation A20 Murine B cell 8649383
DD FADD Link Fas Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 9082980
DD FADD Link Fas Co-immunoprecipitation BJAB 9325306
DD FADD Link Fas Co-immunoprecipitation HEK293 Human Not specified Human 19-335 9430227
DD FADD Link Fas Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 9714541
DD FADD Link Fas Co-immunoprecipitation DT-40 chicken lymphoma B cell 9880544
DD FADD Link Fas Co-immunoprecipitation HE29 10075697
DD FADD Link Fas Co-immunoprecipitation HEK293 Not used Human 174-319 10200300
DD FADD Link Fas Co-immunoprecipitation A20 Murine B cell 10452970
DD FADD Link Fas Co-immunoprecipitation H9 10607716
DD FADD Link Fas Co-immunoprecipitation SHEP neuroblastoma cell 10919673
DD FADD Link Fas Co-immunoprecipitation CD40L-induced B blast 10975811
DD FADD Link Fas Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 11032752
DD FADD Link Fas Co-immunoprecipitation Tonsillar germinal center B cell 11181697
DD FADD Link Fas Co-immunoprecipitation HT29 11313933
DD FADD Link Fas Co-immunoprecipitation Jurkat 11729181
DD FADD Link Fas Co-immunoprecipitation SKW6.4 11729181
DD FADD Link Fas Co-immunoprecipitation SKW6.4 11739735
DD FADD Link Fas Co-immunoprecipitation H9 11739735
DD FADD Link Fas Co-immunoprecipitation Mouse brain cell 11978827
DD FADD Link Fas Co-immunoprecipitation SKW6.4 12110583
DD FADD Link Fas Co-immunoprecipitation H9 12110583
DD FADD Link Fas Co-immunoprecipitation Human Jurkat cell 12878044
DD FADD Link Fas Co-immunoprecipitation HuT-78 12878044
DD FADD Link Fas Co-immunoprecipitation MCF-7 Human Full length Not used 14573612
DD FADD Link Fas Co-immunoprecipitation HEK293 15383280
DD FADD Link Fas Co-immunoprecipitation Human neuronal progenitor cell 15545353
DD FADD Link Fas Co-immunoprecipitation SKW6.4 16498403
DD FADD Link Fas Co-immunoprecipitation SKW6.4 17159907
DD FADD Link Fas Co-immunoprecipitation T98G 18328427
DD FADD Link Fas Co-immunoprecipitation LN-18 18328427
DD FADD Link Fas Fluorescence resonance energy transfer HEK293 Human Not specified Human Full length 20935634
DD FADD Link MALT1 Co-immunoprecipitation Jurkat A3 15746428
DD FADD Link MALT1 Co-immunoprecipitation Caspase8 deficient Jurkat I9.2 15746428
DD FADD Link Myd88 Co-immunoprecipitation HEK293 Not used Human Full length 10880445
DD FADD Link Myd88 Co-immunoprecipitation HEK293 Not used Human 1-151 10880445
DD FADD Link Myd88 Co-immunoprecipitation Drosophila S2 Drosophila Not specified Drosophila 1-237 11606776
DD FADD Link Myd88 Co-immunoprecipitation BALB/C Mouse peritoneal macrophage 21131052
DD FADD Link PIDD Co-immunoprecipitation COS-7 Not specified Not specified Not specified 1-753 10825539
DD FADD Link PIDD Co-immunoprecipitation HEK293 Not used Not specified Not specified 16360037
DD FADD Link RIP Co-Immunofluorescence staining HEK293 Not specified Not specified Human Not specified 11002422
DD FADD Link RIP Co-immunoprecipitation HeLa Not specified 19-753 Not specified 261-372 8642271
DD FADD Link TNFR1 Rat primary hepatocyte 21741934
DD FADD Link TNFR1 Co-immunoprecipitation HEK293 Not specified 2-208 Not specified Not specified 8617770
DD FADD Link TNFR1 Co-immunoprecipitation HEK293 Not specified 80-208 Not specified Not specified 8617770
DD FADD Link TNFR1 Co-immunoprecipitation L929 10463949
DD FADD Link TNFR1 Co-immunoprecipitation Jurkat Not specified Not specified Not specified Not specified 11002422
DD FADD Link TRADD Co-Immunofluorescence staining Human TLE hammacampus section 16919273
DD FADD Link TRADD Co-immunoprecipitation HEK293 Not specified Full length Not specified Full length 8565075
DD FADD Link TRADD Co-immunoprecipitation HeLa Not specified 19-753 Not specified 195-312 8642271
DD FADD Link TRADD Co-immunoprecipitation HeLa 10521396
DD FADD Link TRADD Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 10521396
DD FADD Link TRADD Co-immunoprecipitation COS-7 Not specified Not specified Not specified Not specified 12796506
DD FADD Link TRADD Co-immunoprecipitation Human TLE hammacampus lysate 16919273
DD FADD Link TRADD Co-immunoprecipitation Mouse seizure hippocampal 21760970
DD Fas Link ANK3 Co-Immunofluorescence staining MDCK Not specified Not specified Rat Not specified 14694156
DD Fas Link ANK3 Co-immunoprecipitation MDCK Not specified Not specified Rat Not specified 14694156
DD Fas Link FADD Jurkat 21557211
DD Fas Link FADD Co-Immunofluorescence staining Jurkat 12702723
DD Fas Link FADD Co-Immunofluorescence staining BJAB Not specified Not specified Not specified Not specified 16498403
DD Fas Link FADD Co-immunoprecipitation HeLa Not specified Not specified Not specified Not specified 7536190
DD Fas Link FADD Co-immunoprecipitation HEK293 Not specified 1-304 Not specified Not specified 7538907
DD Fas Link FADD Co-immunoprecipitation HEK293 Not specified Not specified Not specified 80-208 8617770
DD Fas Link FADD Co-immunoprecipitation HEK293 Not specified Not specified Not specified 2-208 8617770
DD Fas Link FADD Co-immunoprecipitation A20 Murine B cell 8649383
DD Fas Link FADD Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 9082980
DD Fas Link FADD Co-immunoprecipitation BJAB 9325306
DD Fas Link FADD Co-immunoprecipitation HEK293 Human 19-335 Human Not specified 9430227
DD Fas Link FADD Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 9714541
DD Fas Link FADD Co-immunoprecipitation DT-40 chicken lymphoma B cell 9880544
DD Fas Link FADD Co-immunoprecipitation HE29 10075697
DD Fas Link FADD Co-immunoprecipitation HEK293 Human 174-319 Not used 10200300
DD Fas Link FADD Co-immunoprecipitation A20 Murine B cell 10452970
DD Fas Link FADD Co-immunoprecipitation H9 10607716
DD Fas Link FADD Co-immunoprecipitation SHEP neuroblastoma cell 10919673
DD Fas Link FADD Co-immunoprecipitation CD40L-induced B blast 10975811
DD Fas Link FADD Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 11032752
DD Fas Link FADD Co-immunoprecipitation Tonsillar germinal center B cell 11181697
DD Fas Link FADD Co-immunoprecipitation HT29 11313933
DD Fas Link FADD Co-immunoprecipitation Jurkat 11729181
DD Fas Link FADD Co-immunoprecipitation SKW6.4 11729181
DD Fas Link FADD Co-immunoprecipitation SKW6.4 11739735
DD Fas Link FADD Co-immunoprecipitation H9 11739735
DD Fas Link FADD Co-immunoprecipitation Mouse brain cell 11978827
DD Fas Link FADD Co-immunoprecipitation SKW6.4 12110583
DD Fas Link FADD Co-immunoprecipitation H9 12110583
DD Fas Link FADD Co-immunoprecipitation Human Jurkat cell 12878044
DD Fas Link FADD Co-immunoprecipitation HuT-78 12878044
DD Fas Link FADD Co-immunoprecipitation MCF-7 Not used Human Full length 14573612
DD Fas Link FADD Co-immunoprecipitation HEK293 15383280
DD Fas Link FADD Co-immunoprecipitation Human neuronal progenitor cell 15545353
DD Fas Link FADD Co-immunoprecipitation SKW6.4 16498403
DD Fas Link FADD Co-immunoprecipitation SKW6.4 17159907
DD Fas Link FADD Co-immunoprecipitation T98G 18328427
DD Fas Link FADD Co-immunoprecipitation LN-18 18328427
DD Fas Link FADD Fluorescence resonance energy transfer HEK293 Human Full length Human Not specified 20935634
DD Fas Link TNFR1 Co-immunoprecipitation C57BL/6J mice macrophage 17692826
DD Fas Link TRADD Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 11032752
DD Fas Link TRADD Co-immunoprecipitation C57BL/6J mice macrophage 17692826
DD IRAK1 Link IRAK1 Co-immunoprecipitation HEK293 Not specified Full length Not specified Full length 10383454
DD IRAK1 Link IRAK1 Co-immunoprecipitation HEK293 Human Full length Human 2-109 17276401
DD IRAK1 Link IRAK1 Co-immunoprecipitation HEK293 Mouse 1-550 Mouse 1-550 19166926
DD IRAK1 Link IRAK2 Co-immunoprecipitation HEK293 Not specified Full length Not specified Full length 10383454
DD IRAK1 Link IRAK2 Fluorescence resonance energy transfer NIH 3T3 Not specified Not specified Not specified Full length 12138165
DD IRAK1 Link IRAK3 Co-immunoprecipitation HEK293 Not specified Full length Human Full length 10383454
DD IRAK1 Link IRAK3 Co-immunoprecipitation HEK293 Mouse 1-550 Not specified Not specified 19166926
DD IRAK1 Link IRAK3 Co-immunoprecipitation Mouse RAW 264.7 macrophage Mouse 1-550 Not specified Not specified 19166926
DD IRAK1 Link IRAK3 Fluorescence resonance energy transfer NIH 3T3 Not specified Not specified Human Not specified 12138165
DD IRAK1 Link IRAK4 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Full length 12538665
DD IRAK1 Link IRAK4 Co-immunoprecipitation HEK293 Not used Human Not specified 15905496
DD IRAK1 Link IRAK4 Co-immunoprecipitation HEK293 Human Not specified Human Not specified 16024789
DD IRAK1 Link IRAK4 Co-immunoprecipitation HEK293 Human Full length Not specified Not specified 17276401
DD IRAK1 Link IRAK4 Co-immunoprecipitation HEK293 Human 2-109 Not specified Not specified 17276401
DD IRAK1 Link IRAK4 Co-immunoprecipitation HEK293 Human 2-712 Not specified Not specified 18524972
DD IRAK1 Link Myd88 Co-immunoprecipitation HEK293 Not specified Full length Not specified 1-151 9430229
DD IRAK1 Link Myd88 Co-immunoprecipitation HEK293 Not specified Full length Not specified 1-151 10383454
DD IRAK1 Link Myd88 Co-immunoprecipitation THP-1 10811644
DD IRAK1 Link Myd88 Co-immunoprecipitation HEK293 Not specified Not specified Not specified 1-172 10854325
DD IRAK1 Link Myd88 Co-immunoprecipitation HEK293 Human 1-215 Human Full length 11960013
DD IRAK1 Link Myd88 Co-immunoprecipitation HEK293 11976320
DD IRAK1 Link Myd88 Co-immunoprecipitation PC12 12034707
DD IRAK1 Link Myd88 Co-immunoprecipitation HEK293 Human Not specified Human Not specified 16024789
DD IRAK1 Link Myd88 Co-immunoprecipitation HEK293 Human Full length Not specified Not specified 17276401
DD IRAK1 Link Myd88 Co-immunoprecipitation HEK293 Human 2-109 Not specified Not specified 17276401
DD IRAK1 Link Myd88 Co-immunoprecipitation Rat thoracic aortas derived vascular smooth muscle cell Not specified 1-710 Not specified 1-306 17510469
DD IRAK1 Link Myd88 Co-immunoprecipitation MT2 17920759
DD IRAK1 Link Myd88 Co-immunoprecipitation HUT102 17920759
DD IRAK1 Link Myd88 Co-immunoprecipitation MT4 17920759
DD IRAK1 Link Myd88 Co-immunoprecipitation HEK293 Human 2-712 Not specified Not specified 18524972
DD IRAK1 Link Myd88 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 19679662
DD IRAK1 Link Myd88 Co-immunoprecipitation HEK293 Not specified 27-72 Not specified Not specified 19679662
DD IRAK1 Link Myd88 Co-immunoprecipitation HEK293 Not specified Not specified Not specified 27-72 19679662
DD IRAK1 Link Myd88 Co-immunoprecipitation GCB DLBCL line BAJB Not used Not specified Not specified 21179087
DD IRAK1 Link NGFR Co-immunoprecipitation PC12 12034707
DD IRAK2 Link IRAK1 Co-immunoprecipitation HEK293 Not specified Full length Not specified Full length 10383454
DD IRAK2 Link IRAK1 Fluorescence resonance energy transfer NIH 3T3 Not specified Full length Not specified Not specified 12138165
DD IRAK2 Link IRAK2 Co-immunoprecipitation HEK293 Not specified Full length Not specified Full length 10383454
DD IRAK2 Link IRAK3 Co-immunoprecipitation HEK293 Not specified Full length Human Full length 10383454
DD IRAK2 Link IRAK4 His fusion protein pull-down E.coli Human 1-112 Human 4-106 20485341
DD IRAK2 Link Myd88 Co-immunoprecipitation HEK293 Human Full length Human Full length 9374458
DD IRAK2 Link Myd88 Co-immunoprecipitation HEK293 Not specified Full length Not specified 1-151 10383454
DD IRAK2 Link Myd88 His fusion protein pull-down E.coli Human 1-112 Human 20-117 20485341
DD IRAK3 Link IRAK1 Co-immunoprecipitation HEK293 Human Full length Not specified Full length 10383454
DD IRAK3 Link IRAK1 Co-immunoprecipitation HEK293 Not specified Not specified Mouse 1-550 19166926
DD IRAK3 Link IRAK1 Co-immunoprecipitation Mouse RAW 264.7 macrophage Not specified Not specified Mouse 1-550 19166926
DD IRAK3 Link IRAK1 Fluorescence resonance energy transfer NIH 3T3 Human Not specified Not specified Not specified 12138165
DD IRAK3 Link IRAK2 Co-immunoprecipitation HEK293 Human Full length Not specified Full length 10383454
DD IRAK3 Link IRAK3 Co-immunoprecipitation HEK293 Human Full length Human Full length 10383454
DD IRAK3 Link Myd88 Co-immunoprecipitation HEK293 Human Full length Not specified 1-151 10383454
DD IRAK4 Link IRAK1 Co-immunoprecipitation HEK293 Not specified Full length Not specified Not specified 12538665
DD IRAK4 Link IRAK1 Co-immunoprecipitation HEK293 Human Not specified Not used 15905496
DD IRAK4 Link IRAK1 Co-immunoprecipitation HEK293 Human Not specified Human Not specified 16024789
DD IRAK4 Link IRAK1 Co-immunoprecipitation HEK293 Not specified Not specified Human Full length 17276401
DD IRAK4 Link IRAK1 Co-immunoprecipitation HEK293 Not specified Not specified Human 2-109 17276401
DD IRAK4 Link IRAK1 Co-immunoprecipitation HEK293 Not specified Not specified Human 2-712 18524972
DD IRAK4 Link IRAK2 His fusion protein pull-down E.coli Human 4-106 Human 1-112 20485341
DD IRAK4 Link Myd88 Co-immunoprecipitation HEK293 Human 1-215 Human Full length 11960013
DD IRAK4 Link Myd88 Co-immunoprecipitation HEK293 Human Not specified Not specified Not specified 15905496
DD IRAK4 Link Myd88 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 19679662
DD IRAK4 Link Myd88 Co-immunoprecipitation HEK293 Human 1-117 Human 1-157 20966070
DD IRAK4 Link Myd88 Co-immunoprecipitation GCB DLBCL line BAJB Not used Not specified Not specified 21179087
DD IRAK4 Link Myd88 His fusion protein pull-down E.coli Human 4-106 Human 20-117 20485341
DD MADD Link DR4 Co-immunoprecipitation HEK293 Human Full length Not specified Not specified 15208670
DD MADD Link DR4 Co-immunoprecipitation HEK293 Human 628-1376 Not specified Not specified 15208670
DD MADD Link DR4 Fluorescence resonance energy transfer HeLa Human Full length Not specified Not specified 15208670
DD MADD Link DR5 Co-immunoprecipitation HEK293 Human Full length Not specified Not specified 15208670
DD MADD Link DR5 Co-immunoprecipitation HEK293 Human 628-1376 Not specified Not specified 15208670
DD MADD Link PIDD Co-immunoprecipitation COS-7 Not specified Not specified Not specified 1-753 10825539
DD MADD Link TNFR1 Co-immunoprecipitation COS-7 Not specified Full length Not used 9115275
DD MADD Link TNFR1 Co-immunoprecipitation CCL-131 Not specified Not specified Not specified Not specified 15007167
DD MADD Link TRADD Co-immunoprecipitation CCL-131 Not specified Not specified Not specified Not specified 15007167
DD MALT1 Link FADD Co-immunoprecipitation Jurkat A3 15746428
DD MALT1 Link FADD Co-immunoprecipitation Caspase8 deficient Jurkat I9.2 15746428
DD Myd88 Link FADD Co-immunoprecipitation HEK293 Human Full length Not used 10880445
DD Myd88 Link FADD Co-immunoprecipitation HEK293 Human 1-151 Not used 10880445
DD Myd88 Link FADD Co-immunoprecipitation Drosophila S2 Drosophila 1-237 Drosophila Not specified 11606776
DD Myd88 Link FADD Co-immunoprecipitation BALB/C Mouse peritoneal macrophage 21131052
DD Myd88 Link IRAK1 Co-immunoprecipitation HEK293 Not specified 1-151 Not specified Full length 9430229
DD Myd88 Link IRAK1 Co-immunoprecipitation HEK293 Not specified 1-151 Not specified Full length 10383454
DD Myd88 Link IRAK1 Co-immunoprecipitation THP-1 10811644
DD Myd88 Link IRAK1 Co-immunoprecipitation HEK293 Not specified 1-172 Not specified Not specified 10854325
DD Myd88 Link IRAK1 Co-immunoprecipitation HEK293 Human Full length Human 1-215 11960013
DD Myd88 Link IRAK1 Co-immunoprecipitation HEK293 11976320
DD Myd88 Link IRAK1 Co-immunoprecipitation PC12 12034707
DD Myd88 Link IRAK1 Co-immunoprecipitation HEK293 Human Not specified Human Not specified 16024789
DD Myd88 Link IRAK1 Co-immunoprecipitation HEK293 Not specified Not specified Human Full length 17276401
DD Myd88 Link IRAK1 Co-immunoprecipitation HEK293 Not specified Not specified Human 2-109 17276401
DD Myd88 Link IRAK1 Co-immunoprecipitation Rat thoracic aortas derived vascular smooth muscle cell Not specified 1-306 Not specified 1-710 17510469
DD Myd88 Link IRAK1 Co-immunoprecipitation MT2 17920759
DD Myd88 Link IRAK1 Co-immunoprecipitation HUT102 17920759
DD Myd88 Link IRAK1 Co-immunoprecipitation MT4 17920759
DD Myd88 Link IRAK1 Co-immunoprecipitation HEK293 Not specified Not specified Human 2-712 18524972
DD Myd88 Link IRAK1 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 19679662
DD Myd88 Link IRAK1 Co-immunoprecipitation HEK293 Not specified Not specified Not specified 27-72 19679662
DD Myd88 Link IRAK1 Co-immunoprecipitation HEK293 Not specified 27-72 Not specified Not specified 19679662
DD Myd88 Link IRAK1 Co-immunoprecipitation GCB DLBCL line BAJB Not specified Not specified Not used 21179087
DD Myd88 Link IRAK2 Co-immunoprecipitation HEK293 Human Full length Human Full length 9374458
DD Myd88 Link IRAK2 Co-immunoprecipitation HEK293 Not specified 1-151 Not specified Full length 10383454
DD Myd88 Link IRAK2 His fusion protein pull-down E.coli Human 20-117 Human 1-112 20485341
DD Myd88 Link IRAK3 Co-immunoprecipitation HEK293 Not specified 1-151 Human Full length 10383454
DD Myd88 Link IRAK4 Co-immunoprecipitation HEK293 Human Full length Human 1-215 11960013
DD Myd88 Link IRAK4 Co-immunoprecipitation HEK293 Not specified Not specified Human Not specified 15905496
DD Myd88 Link IRAK4 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 19679662
DD Myd88 Link IRAK4 Co-immunoprecipitation HEK293 Human 1-157 Human 1-117 20966070
DD Myd88 Link IRAK4 Co-immunoprecipitation GCB DLBCL line BAJB Not specified Not specified Not used 21179087
DD Myd88 Link IRAK4 His fusion protein pull-down E.coli Human 20-117 Human 4-106 20485341
DD Myd88 Link Myd88 Co-immunoprecipitation HEK293 Mouse 1-296 Mouse 1-296 11909531
DD Myd88 Link Myd88 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 19679662
DD Myd88 Link Myd88 Co-immunoprecipitation HEK293 Human 1-157 Human 1-157 20966070
DD Myd88 Link Myd88 Size-exclusion chromatography HEK293 Mouse Full length Mouse Full length 9575168
DD Myd88 Link NGFR Co-immunoprecipitation PC12 12034707
DD NF-kB1 Link NF-kB2 Co-immunoprecipitation U2OS 17962807
DD NF-kB2 Link NF-kB1 Co-immunoprecipitation U2OS 17962807
DD NGFR Link IRAK1 Co-immunoprecipitation PC12 12034707
DD NGFR Link Myd88 Co-immunoprecipitation PC12 12034707
DD NGFR Link TRADD Co-Immunofluorescence staining MCF-7 12604596
DD NGFR Link TRADD Co-immunoprecipitation MCF-7 12604596
DD PIDD Link FADD Co-immunoprecipitation COS-7 Not specified 1-753 Not specified Not specified 10825539
DD PIDD Link FADD Co-immunoprecipitation HEK293 Not specified Not specified Not used 16360037
DD PIDD Link MADD Co-immunoprecipitation COS-7 Not specified 1-753 Not specified Not specified 10825539
DD PIDD Link RAIDD Co-Immunofluorescence staining HCT116 16652156
DD PIDD Link RAIDD Co-immunoprecipitation HEK293 Not specified Full length Not specified 101-199 15073321
DD PIDD Link RAIDD Co-immunoprecipitation Jurkat Not specified Not specified Not used 16360037
DD PIDD Link RAIDD Co-immunoprecipitation HCT116 16652156
DD PIDD Link RAIDD Co-immunoprecipitation HEK293 Not specified 588-910 Not specified Not specified 17159900
DD PIDD Link RAIDD Co-immunoprecipitation HEK293 Not specified 777-883 Human 94-199 17289572
DD PIDD Link RAIDD Co-immunoprecipitation Hippocampal CA1 subregion 18845684
DD PIDD Link RAIDD Co-immunoprecipitation HEK293 Not specified Not specified Not used 20966961
DD PIDD Link RAIDD Size-exclusion chromatography HEK293 Not specified Not specified Not used 20966961
DD PIDD Link RIP Co-immunoprecipitation HEK293 Not specified Not specified Not used 16360037
DD PIDD Link RIP Co-immunoprecipitation HEK293 Not specified 446-910 Not specified Not specified 17159900
DD RAIDD Link PIDD Co-Immunofluorescence staining HCT116 16652156
DD RAIDD Link PIDD Co-immunoprecipitation HEK293 Not specified 101-199 Not specified Full length 15073321
DD RAIDD Link PIDD Co-immunoprecipitation Jurkat Not used Not specified Not specified 16360037
DD RAIDD Link PIDD Co-immunoprecipitation HCT116 16652156
DD RAIDD Link PIDD Co-immunoprecipitation HEK293 Not specified Not specified Not specified 588-910 17159900
DD RAIDD Link PIDD Co-immunoprecipitation HEK293 Human 94-199 Not specified 777-883 17289572
DD RAIDD Link PIDD Co-immunoprecipitation Hippocampal CA1 subregion 18845684
DD RAIDD Link PIDD Co-immunoprecipitation HEK293 Not used Not specified Not specified 20966961
DD RAIDD Link PIDD Size-exclusion chromatography HEK293 Not used Not specified Not specified 20966961
DD RAIDD Link RIP Co-immunoprecipitation Mouse brain cell 11978827
DD RIP Link DR4 Co-immunoprecipitation HEK293 Human 559-671 Human 1-351 10958661
DD RIP Link DR4 His fusion protein pull-down HEK293 Human Not specified Human 106-468 9430227
DD RIP Link DR5 Co-immunoprecipitation HEK293 Human Not specified Human 51-411 9430227
DD RIP Link FADD Co-Immunofluorescence staining HEK293 Human Not specified Not specified Not specified 11002422
DD RIP Link FADD Co-immunoprecipitation HeLa Not specified 261-372 Not specified 19-753 8642271
DD RIP Link PIDD Co-immunoprecipitation HEK293 Not used Not specified Not specified 16360037
DD RIP Link PIDD Co-immunoprecipitation HEK293 Not specified Not specified Not specified 446-910 17159900
DD RIP Link RAIDD Co-immunoprecipitation Mouse brain cell 11978827
DD RIP Link TNFR1 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 8612133
DD RIP Link TNFR1 Co-immunoprecipitation HEK293 Not specified Full length Not specified Not specified 8612133
DD RIP Link TNFR1 Co-immunoprecipitation HEK293 Not specified 240-671 Not specified Not specified 8612133
DD RIP Link TNFR1 Co-immunoprecipitation HEK293 Not specified 559-671 Not specified Not specified 8612133
DD RIP Link TNFR1 Co-immunoprecipitation HEK293 Not specified 37-205 Not specified Not specified 9082980
DD RIP Link TNFR1 Co-immunoprecipitation HEK293 Not specified Not specified Not specified 37-205 9082980
DD RIP Link TNFR1 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 9714541
DD RIP Link TNFR1 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 10358032
DD RIP Link TNFR1 Co-immunoprecipitation HEK293 Human Not specified Not used 10755617
DD RIP Link TNFR1 Co-immunoprecipitation Fibroblast 10795740
DD RIP Link TNFR1 Co-immunoprecipitation Jurkat Human Not specified Not specified Not specified 11002422
DD RIP Link TNFR1 Co-immunoprecipitation U937 11734559
DD RIP Link TNFR1 Co-immunoprecipitation Jurkat 12167698
DD RIP Link TNFR1 Co-immunoprecipitation Jurkat 16611992
DD RIP Link TNFR1 Co-immunoprecipitation Mice peritoneal macrophage lysate 18641653
DD RIP Link TNFR1 Co-immunoprecipitation HT1080 18939944
DD RIP Link TNFR1 Co-immunoprecipitation Jurkat 19524513
DD RIP Link TNFR1 Co-immunoprecipitation H2009 20547836
DD RIP Link TRADD Co-immunoprecipitation HEK293 Not specified Full length Not specified Not specified 8612133
DD RIP Link TRADD Co-immunoprecipitation HEK293 Not specified 240-671 Not specified Not specified 8612133
DD RIP Link TRADD Co-immunoprecipitation HEK293 Not specified 559-671 Not specified Not specified 8612133
DD RIP Link TRADD Co-immunoprecipitation HeLa Not specified 261-372 Not specified 195-312 8642271
DD RIP Link TRADD Co-immunoprecipitation HeLa 10521396
DD RIP Link TRADD Co-immunoprecipitation HEK293 Not used Not specified Not specified 10521396
DD RIP Link TRADD Co-immunoprecipitation Rat brain hippocampus 12786973
DD TNFR1 Link DAPK1 Co-Immunofluorescence staining Rat brain cell 12911633
DD TNFR1 Link DAPK1 Co-immunoprecipitation Rat brain cell 12911633
DD TNFR1 Link FADD Rat primary hepatocyte 21741934
DD TNFR1 Link FADD Co-immunoprecipitation HEK293 Not specified Not specified Not specified 2-208 8617770
DD TNFR1 Link FADD Co-immunoprecipitation HEK293 Not specified Not specified Not specified 80-208 8617770
DD TNFR1 Link FADD Co-immunoprecipitation L929 10463949
DD TNFR1 Link FADD Co-immunoprecipitation Jurkat Not specified Not specified Not specified Not specified 11002422
DD TNFR1 Link Fas Co-immunoprecipitation C57BL/6J mice macrophage 17692826
DD TNFR1 Link MADD Co-immunoprecipitation COS-7 Not used Not specified Full length 9115275
DD TNFR1 Link MADD Co-immunoprecipitation CCL-131 Not specified Not specified Not specified Not specified 15007167
DD TNFR1 Link RIP Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 8612133
DD TNFR1 Link RIP Co-immunoprecipitation HEK293 Not specified Not specified Not specified Full length 8612133
DD TNFR1 Link RIP Co-immunoprecipitation HEK293 Not specified Not specified Not specified 240-671 8612133
DD TNFR1 Link RIP Co-immunoprecipitation HEK293 Not specified Not specified Not specified 559-671 8612133
DD TNFR1 Link RIP Co-immunoprecipitation HEK293 Not specified Not specified Not specified 37-205 9082980
DD TNFR1 Link RIP Co-immunoprecipitation HEK293 Not specified 37-205 Not specified Not specified 9082980
DD TNFR1 Link RIP Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 9714541
DD TNFR1 Link RIP Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 10358032
DD TNFR1 Link RIP Co-immunoprecipitation HEK293 Not used Human Not specified 10755617
DD TNFR1 Link RIP Co-immunoprecipitation Fibroblast 10795740
DD TNFR1 Link RIP Co-immunoprecipitation Jurkat Not specified Not specified Human Not specified 11002422
DD TNFR1 Link RIP Co-immunoprecipitation U937 11734559
DD TNFR1 Link RIP Co-immunoprecipitation Jurkat 12167698
DD TNFR1 Link RIP Co-immunoprecipitation Jurkat 16611992
DD TNFR1 Link RIP Co-immunoprecipitation Mice peritoneal macrophage lysate 18641653
DD TNFR1 Link RIP Co-immunoprecipitation HT1080 18939944
DD TNFR1 Link RIP Co-immunoprecipitation Jurkat 19524513
DD TNFR1 Link RIP Co-immunoprecipitation H2009 20547836
DD TNFR1 Link TRADD Rat primary hepatocyte 21741934
DD TNFR1 Link TRADD Co-immunoprecipitation HEK293 Human Not specified Human Not specified 7758105
DD TNFR1 Link TRADD Co-immunoprecipitation U937 8565075
DD TNFR1 Link TRADD Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 8612133
DD TNFR1 Link TRADD Co-immunoprecipitation HEK293 Not specified Not specified Human 112-312 8621670
DD TNFR1 Link TRADD Co-immunoprecipitation U937 8943045
DD TNFR1 Link TRADD Co-immunoprecipitation HEK293 Not specified 37-205 Not specified Not specified 9082980
DD TNFR1 Link TRADD Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 9915703
DD TNFR1 Link TRADD Co-immunoprecipitation U937 9916731
DD TNFR1 Link TRADD Co-immunoprecipitation HEK293 Not used Not specified Not specified 10187805
DD TNFR1 Link TRADD Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 10358032
DD TNFR1 Link TRADD Co-immunoprecipitation L929 10463949
DD TNFR1 Link TRADD Co-immunoprecipitation Fibroblast 10795740
DD TNFR1 Link TRADD Co-immunoprecipitation Jurkat Not specified Not specified Not specified Not specified 11002422
DD TNFR1 Link TRADD Co-immunoprecipitation Jurkat 12167698
DD TNFR1 Link TRADD Co-immunoprecipitation Rat brain hippocampus 12786973
DD TNFR1 Link TRADD Co-immunoprecipitation Jurkat 16611992
DD TNFR1 Link TRADD Co-immunoprecipitation L929 16798936
DD TNFR1 Link TRADD Co-immunoprecipitation Human TLE hammacampus lysate 16919273
DD TNFR1 Link TRADD Co-immunoprecipitation HT1080 18939944
DD TNFR1 Link TRADD Co-immunoprecipitation Mouse seizure hippocampal 21760970
DD TRADD Link DR3 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 8934525
DD TRADD Link DR3 Co-immunoprecipitation HEK293 Not specified Not specified Human Not specified 9430227
DD TRADD Link DR3 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 9714541
DD TRADD Link DR4 Co-immunoprecipitation HEK293 Human 121-312 Human 106-468 9430227
DD TRADD Link DR4 Co-immunoprecipitation HEK293 Not specified Not specified Not specified 261-465 9430228
DD TRADD Link DR5 Co-immunoprecipitation HEK293 Human 121-312 Human 51-411 9430227
DD TRADD Link DR5 Co-immunoprecipitation HEK293 Not specified Not specified Not specified 261-465 9430228
DD TRADD Link DR5 Co-immunoprecipitation HEK293 Not specified Not specified Not specified 232-439 9430228
DD TRADD Link DR6 Co-immunoprecipitation HEK293 Not specified Not specified Not specified 42-655 9714541
DD TRADD Link FADD Co-Immunofluorescence staining Human TLE hammacampus section 16919273
DD TRADD Link FADD Co-immunoprecipitation HEK293 Not specified Full length Not specified Full length 8565075
DD TRADD Link FADD Co-immunoprecipitation HeLa Not specified 195-312 Not specified 19-753 8642271
DD TRADD Link FADD Co-immunoprecipitation HeLa 10521396
DD TRADD Link FADD Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 10521396
DD TRADD Link FADD Co-immunoprecipitation COS-7 Not specified Not specified Not specified Not specified 12796506
DD TRADD Link FADD Co-immunoprecipitation Human TLE hammacampus lysate 16919273
DD TRADD Link FADD Co-immunoprecipitation Mouse seizure hippocampal 21760970
DD TRADD Link Fas Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 11032752
DD TRADD Link Fas Co-immunoprecipitation C57BL/6J mice macrophage 17692826
DD TRADD Link MADD Co-immunoprecipitation CCL-131 Not specified Not specified Not specified Not specified 15007167
DD TRADD Link NGFR Co-Immunofluorescence staining MCF-7 12604596
DD TRADD Link NGFR Co-immunoprecipitation MCF-7 12604596
DD TRADD Link RIP Co-immunoprecipitation HEK293 Not specified Not specified Not specified Full length 8612133
DD TRADD Link RIP Co-immunoprecipitation HEK293 Not specified Not specified Not specified 240-671 8612133
DD TRADD Link RIP Co-immunoprecipitation HEK293 Not specified Not specified Not specified 559-671 8612133
DD TRADD Link RIP Co-immunoprecipitation HeLa Not specified 195-312 Not specified 261-372 8642271
DD TRADD Link RIP Co-immunoprecipitation HeLa 10521396
DD TRADD Link RIP Co-immunoprecipitation HEK293 Not specified Not specified Not used 10521396
DD TRADD Link RIP Co-immunoprecipitation Rat brain hippocampus 12786973
DD TRADD Link TNFR1 Rat primary hepatocyte 21741934
DD TRADD Link TNFR1 Co-immunoprecipitation HEK293 Human Not specified Human Not specified 7758105
DD TRADD Link TNFR1 Co-immunoprecipitation U937 8565075
DD TRADD Link TNFR1 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 8612133
DD TRADD Link TNFR1 Co-immunoprecipitation HEK293 Human 112-312 Not specified Not specified 8621670
DD TRADD Link TNFR1 Co-immunoprecipitation U937 8943045
DD TRADD Link TNFR1 Co-immunoprecipitation HEK293 Not specified Not specified Not specified 37-205 9082980
DD TRADD Link TNFR1 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 9915703
DD TRADD Link TNFR1 Co-immunoprecipitation U937 9916731
DD TRADD Link TNFR1 Co-immunoprecipitation HEK293 Not specified Not specified Not used 10187805
DD TRADD Link TNFR1 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 10358032
DD TRADD Link TNFR1 Co-immunoprecipitation L929 10463949
DD TRADD Link TNFR1 Co-immunoprecipitation Fibroblast 10795740
DD TRADD Link TNFR1 Co-immunoprecipitation Jurkat Not specified Not specified Not specified Not specified 11002422
DD TRADD Link TNFR1 Co-immunoprecipitation Jurkat 12167698
DD TRADD Link TNFR1 Co-immunoprecipitation Rat brain hippocampus 12786973
DD TRADD Link TNFR1 Co-immunoprecipitation Jurkat 16611992
DD TRADD Link TNFR1 Co-immunoprecipitation L929 16798936
DD TRADD Link TNFR1 Co-immunoprecipitation Human TLE hammacampus lysate 16919273
DD TRADD Link TNFR1 Co-immunoprecipitation HT1080 18939944
DD TRADD Link TNFR1 Co-immunoprecipitation Mouse seizure hippocampal 21760970
DD TRADD Link TRADD Co-immunoprecipitation HEK293 Human 112-312 Human 1-312 8621670
DD UNC5B Link DAPK1 Co-immunoprecipitation HEK293 Not specified Full length Not specified Full length 15729359
DD UNC5B Link DAPK1 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Full length 15729359
DD UNC5B Link DAPK1 Co-immunoprecipitation HEK293 Not specified 841-945 Not specified Full length 15729359
DD UNC5B Link DAPK1 Co-immunoprecipitation HEK293 Not specified 631-945 Not specified Full length 15729359
DD UNC5B Link DAPK1 Co-immunoprecipitation HEK293 Not specified Full length Not specified 1301-1431 15729359
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Characterization
  Stoichiometry Affinity Protein-Protein interface Reference
Family DD1 DD2 Method Mutation Complex structure
DD DR3 Link DR3 Yeast two-hybrid L354A, L356A, D373A (DR3) 8934525
DD DR3 Link TNFR1 Yeast two-hybrid L354A, L356A, D373A (DR3) 8934525
DD EDAR Link EDARADD GST fusion protein pull-down E142K (EDARADD) 11780064
DD EDARADD Link EDAR GST fusion protein pull-down E142K (EDARADD) 11780064
DD FADD Link Fas Mass spectrometry, MALS 5:5, 5:6, 5:7 20935634
DD FADD Link Fas Co-immunoprecipitation V238N, D244V, Q257X, A241D, I294S (Fas) 10200300
DD FADD Link Fas Co-immunoprecipitation R113E, D123R, R166E, Q169A, D175R, D106A, K125A, R142A (FADD) 14573612
DD FADD Link Fas Fluorescence resonance energy transfer D260V, D260Y, A257D, E261K, T270K, E272K, Q283K (Fas) R117E, D123R, R135E, R172E (FADD) 20935634
DD FADD Link Fas GST fusion protein pull-down T225P, Q257X, A241D, I294S, D244V, R234Q, L278X, R234P, Q260X, I238N (Fas) 10200300
DD FADD Link Fas GST fusion protein pull-down R113E, R117E, D123R, R166E, L172E, D175R, D106A, K125A, R142A, R146A (FADD) 14573612
DD FADD Link Fas Structure 4:4 L172A (FADD) 3EZQ 19118384
DD FADD Link Fas His fusion protein pull-down E261K, E272K, T270K, R250E, Q283K, K287D, R250Q, D260Y, A257D, E272K, T270K (fas) 20935634
DD FADD Link Fas Structure 5:5 3OQ9 20935634
DD FADD Link Fas Surface plasmon resonance 1.0E+07M-1 R110A, R113A, R117A, E118A, V121N, E123A (FADD) 10347191
DD FADD Link Fas Yeast two-hybrid R117A (FADD) 12107169
DD FADD Link Fas Yeast two-hybrid V108E(FADD) 15173180
DD FADD Link RIP1 GST fusion protein pull-down Q169A, N171A (FADD) G595A, K596A, E620A, D622A (RIP1) 22922561
DD FADD Link RIP1 Surface plasmon resonance 323nM 22922561
DD FADD Link TRADD GST fusion protein pull-down D246R, E255R, Q267A, R278A (TRADD) R113E, R117E, D123R, D175R (FADD) 16006552
DD Fas Link FADD Mass spectrometry, MALS 5:5, 5:6, 5:7 20935634
DD Fas Link FADD Co-immunoprecipitation V238N, D244V, Q257X, A241D, I294S (Fas) 10200300
DD Fas Link FADD Co-immunoprecipitation R113E, D123R, R166E, Q169A, D175R, D106A, K125A, R142A (FADD) 14573612
DD Fas Link FADD Fluorescence resonance energy transfer D260V, D260Y, A257D, E261K, T270K, E272K, Q283K (Fas) R117E, D123R, R135E, R172E (FADD) 20935634
DD Fas Link FADD GST fusion protein pull-down T225P, Q257X, A241D, I294S, D244V, R234Q, L278X, R234P, Q260X, I238N (Fas) 10200300
DD Fas Link FADD GST fusion protein pull-down R113E, R117E, D123R, R166E, L172E, D175R, D106A, K125A, R142A, R146A (FADD) 14573612
DD Fas Link FADD Structure 4:4 L172A (FADD) 3EZQ 19118384
DD Fas Link FADD His fusion protein pull-down E261K, E272K, T270K, R250E, Q283K, K287D, R250Q, D260Y, A257D, E272K, T270K (fas) 20935634
DD Fas Link FADD Structure 5:5 3OQ9 20935634
DD Fas Link FADD Surface plasmon resonance 1.0E+07M-1 R110A, R113A, R117A, E118A, V121N, E123A (FADD) 10347191
DD Fas Link FADD Yeast two-hybrid R117A (FADD) 12107169
DD Fas Link FADD Yeast two-hybrid V108E(FADD) 15173180
DD IRAK1 Link Myd88 Co-immunoprecipitation E52A and E53A, Y58A, K95A (Myd88) 19679662
DD IRAK2 Link IRAK4 Structure 6:4:4 Y6D, W62D, M66D, R67D (IRAK2) 3MOP 20485341
DD IRAK2 Link Myd88 Structure 6:4:4 3MOP 20485341
DD IRAK4 Link IRAK2 Structure 6:4:4 Y6D, W62D, M66D, R67D (IRAK2) 3MOP 20485341
DD IRAK4 Link Myd88 Co-immunoprecipitation E52A and E53A, Y58A, K95A (Myd88) 19679662
DD IRAK4 Link Myd88 Co-immunoprecipitation S34Y, R98C (Myd88) 20966070
DD IRAK4 Link Myd88 Structure 6:4:4 N16E and R20E, E69K, T76E, N78E, R12A (IRAK4) V43D, E52K, I61A, Y58A and R62A, R62E, A44E (Myd88) 3MOP 20485341
DD IRAK4 Link Myd88 Gel filtration 4:7, 4:8 19592493
DD IRAK4 Link Myd88 Gel filtration 7:4, 8:4 19592493
DD IRAK4 Link Myd88 In vitro purification protein assembly(Size-exclusion chromatography) S34Y, R98C (Myd88) 20966070
DD Myd88 Link IRAK1 Co-immunoprecipitation E52A and E53A, Y58A, K95A (Myd88) 19679662
DD Myd88 Link IRAK2 Structure 6:4:4 3MOP 20485341
DD Myd88 Link IRAK4 Co-immunoprecipitation E52A and E53A, Y58A, K95A (Myd88) 19679662
DD Myd88 Link IRAK4 Co-immunoprecipitation S34Y, R98C (Myd88) 20966070
DD Myd88 Link IRAK4 Structure 6:4:4 N16E and R20E, E69K, T76E, N78E, R12A (IRAK4) V43D, E52K, I61A, Y58A and R62A, R62E, A44E (Myd88) 3MOP 20485341
DD Myd88 Link IRAK4 Gel filtration 4:7, 4:8 19592493
DD Myd88 Link IRAK4 Gel filtration 7:4, 8:4 19592493
DD Myd88 Link IRAK4 In vitro purification protein assembly(Size-exclusion chromatography) S34Y, R98C (Myd88) 20966070
DD PIDD Link RAIDD Gel filtration 5:7 2OF5 17289572
DD PIDD Link RAIDD Gel filtration 7:5 2OF5 17289572
DD PIDD Link RAIDD Gel filtration 5:7 20872280
DD PIDD Link RAIDD Gel filtration 7:5 20872280
DD RAIDD Link PIDD Gel filtration 5:7 2OF5 17289572
DD RAIDD Link PIDD Gel filtration 7:5 2OF5 17289572
DD RAIDD Link PIDD Gel filtration 5:7 20872280
DD RAIDD Link PIDD Gel filtration 7:5 20872280
DD RIP1 Link FADD GST fusion protein pull-down Q169A, N171A (FADD) G595A, K596A, E620A, D622A (RIP1) 22922561
DD RIP1 Link FADD Surface plasmon resonance 323nM 22922561
DD TNFR1 Link DR3 Yeast two-hybrid L354A, L356A, D373A (DR3) 8934525
DD TNFR1 Link TRADD GST fusion protein pull-down 196-312 substituted A(TRADD) 8621670
DD TNFR1 Link TRADD GST fusion protein pull-down Q220E, R224E, D246R, F266E, Q267A, A275D (TRADD) R341E, R437A, G403E, E406R (TNFR1) 16006552
DD TRADD Link FADD GST fusion protein pull-down D246R, E255R, Q267A, R278A (TRADD) R113E, R117E, D123R, D175R (FADD) 16006552
DD TRADD Link TNFR1 GST fusion protein pull-down 196-312 substituted A(TRADD) 8621670
DD TRADD Link TNFR1 GST fusion protein pull-down Q220E, R224E, D246R, F266E, Q267A, A275D (TRADD) R341E, R437A, G403E, E406R (TNFR1) 16006552
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Functional Role
Family DD1 DD2 Method Death-related Death-unrelated Reference
DD DAPK1 Link UNC5B Trypan blue staining, Immunoprecipitation Apoptosis, DAPK kinase activity increase 15729359
DD DR4 Link FADD β-galactosidase staining Apoptosis (DISC) 9430227
DD DR4 Link FADD Cytoplasmic histone associated DNA fragment detection Apoptosis (DISC) 9430228
DD DR4 Link FADD Caspase cleaved assay Caspase8 activation 15452120
DD DR4 Link FADD Immunofluorescence staining Apoptosis (DISC) 21272366
DD DR4 Link FADD Annexin V staining Apoptosis (DISC) 12920112
DD DR4 Link MADD Immunofluorescence staining Apoptosis (DISC) 15208670
DD DR4 Link RIP IKK assay, JNK assay IkB activation, JNK activation 10958661
DD DR4 Link TRADD Luciferase assay NF-kB activation 9430227
DD DR5 Link FADD β-galactosidase staining Apoptosis (DISC) 9430227
DD DR5 Link FADD Cytoplasmic histone associated DNA fragment detection Apoptosis (DISC) 9430228
DD DR5 Link FADD Caspase cleaved assay Caspase8 activation 15452120
DD DR5 Link FADD Immunofluorescence staining Apoptosis (DISC) 21272366
DD DR5 Link FADD Annexin V staining Apoptosis (DISC) 12920112
DD DR5 Link MADD Immunofluorescence staining Apoptosis (DISC) 15208670
DD DR5 Link TRADD Luciferase assay NF-kB activation 9430227
DD EDAR Link EDARADD Luciferase assay NF-kB activation 11780064
DD EDAR Link EDARADD Luciferase assay NF-kB activation 17354266
DD EDARADD Link EDAR Luciferase assay NF-kB activation 11780064
DD EDARADD Link EDAR Luciferase assay NF-kB activation 17354266
DD FADD Link DR4 β-galactosidase staining Apoptosis (DISC) 9430227
DD FADD Link DR4 Cytoplasmic histone associated DNA fragment detection Apoptosis (DISC) 9430228
DD FADD Link DR4 Caspase cleaved assay Caspase8 activation 15452120
DD FADD Link DR4 Immunofluorescence staining Apoptosis (DISC) 21272366
DD FADD Link DR4 Annexin V staining Apoptosis (DISC) 12920112
DD FADD Link DR5 β-galactosidase staining Apoptosis (DISC) 9430227
DD FADD Link DR5 Cytoplasmic histone associated DNA fragment detection Apoptosis (DISC) 9430228
DD FADD Link DR5 Caspase cleaved assay Caspase8 activation 15452120
DD FADD Link DR5 Immunofluorescence staining Apoptosis (DISC) 21272366
DD FADD Link DR5 Annexin V staining Apoptosis (DISC) 12920112
DD FADD Link Fas MTT assay Apoptosis (DISC) 21557211
DD FADD Link Fas MTT assay Apoptosis (DISC) 8617770
DD FADD Link Fas Propidium iodide staining Apoptosis (DISC) 8649383
DD FADD Link Fas Propidium iodide staining Apoptosis (DISC) 9325306
DD FADD Link Fas Propidium iodide staining Apoptosis (DISC) 10607716
DD FADD Link Fas Propidium iodide staining Apoptosis (DISC) 10919673
DD FADD Link RIP Propidium iodide staining Apoptosis (DISC) 11002422
DD FADD Link TNFR1 MTT assay Apoptosis (DISC) 8617770
DD Fas Link FADD MTT assay Apoptosis (DISC) 21557211
DD Fas Link FADD MTT assay Apoptosis (DISC) 8617770
DD Fas Link FADD Propidium iodide staining Apoptosis (DISC) 8649383
DD Fas Link FADD Propidium iodide staining Apoptosis (DISC) 9325306
DD Fas Link FADD Propidium iodide staining Apoptosis (DISC) 10607716
DD Fas Link FADD Propidium iodide staining Apoptosis (DISC) 10919673
DD IRAK1 Link IRAK2 Kinase assay IRAK2 activation 10383454
DD IRAK1 Link IRAK3 Kinase assay IRAK3 activation 10383454
DD IRAK1 Link IRAK4 Kinase assay IRAK1 phosphorylation 16024789
DD IRAK1 Link Myd88 Luciferase assay NF-kB activation 9430229
DD IRAK1 Link Myd88 Luciferase assay NF-kB-activation 19679662
DD IRAK1 Link NGFR Luciferase assay NF-kB activation 12034707
DD IRAK2 Link IRAK1 Kinase assay IRAK2 activation 10383454
DD IRAK2 Link Myd88 Luciferase assay NF-kB activation (Myddosome) 9374458
DD IRAK3 Link IRAK1 Kinase assay IRAK3 activation 10383454
DD IRAK4 Link IRAK1 Kinase assay IRAK1 phosphorylation 16024789
DD IRAK4 Link Myd88 Luciferase assay NF-kB activation (Myddosome) 20966070
DD IRAK4 Link Myd88 Kinase assay IRAK4 mediated IRAK1 phosphorylation 12538665
DD MADD Link DR4 Immunofluorescence staining Apoptosis (DISC) 15208670
DD MADD Link DR5 Immunofluorescence staining Apoptosis (DISC) 15208670
DD MADD Link TRADD Annexin V staining, Immunoprecipitation Apoptosis inhibition, TRADD-TNFR1 interaction block 15007167
DD Myd88 Link IRAK1 Luciferase assay NF-kB activation 9430229
DD Myd88 Link IRAK1 Luciferase assay NF-kB-activation 19679662
DD Myd88 Link IRAK2 Luciferase assay NF-kB activation (Myddosome) 9374458
DD Myd88 Link IRAK4 Luciferase assay NF-kB activation (Myddosome) 20966070
DD Myd88 Link IRAK4 Kinase assay IRAK4 mediated IRAK1 phosphorylation 12538665
DD NGFR Link IRAK1 Luciferase assay NF-kB activation 12034707
DD NGFR Link TRADD Co-Immunofluorescence staining NF-kB activation 12604596
DD PIDD Link RAIDD Trypan blue staining Apoptosis (PIDDosome) 15073321
DD PIDD Link RAIDD Caspase cleaved assay Caspase2 activation (PIDDosome) 17159900
DD PIDD Link RAIDD TUNEL assay Apoptosis (PIDDosome) 18845684
DD PIDD Link RIP NEMO sumoylation, Ubquitination assay NF-kB activation 16360037
DD PIDD Link RIP Kinase assay NF-kB activation 17159900
DD RAIDD Link PIDD Trypan blue staining Apoptosis (PIDDosome) 15073321
DD RAIDD Link PIDD Caspase cleaved assay Caspase2 activation (PIDDosome) 17159900
DD RAIDD Link PIDD TUNEL assay Apoptosis (PIDDosome) 18845684
DD RIP Link DR4 IKK assay, JNK assay IkB activation, JNK activation 10958661
DD RIP Link FADD Propidium iodide staining Apoptosis (DISC) 11002422
DD RIP Link PIDD NEMO sumoylation, Ubquitination assay NF-kB activation 16360037
DD RIP Link PIDD Kinase assay NF-kB activation 17159900
DD RIP Link TNFR1 Data not shown Apoptosis (DISC) 8612133
DD RIP Link TNFR1 IKK assay NF-kB activation (DISC) 10795740
DD RIP Link TNFR1 Propidium iodide staining Apoptosis (DISC) 11002422
DD RIP Link TNFR1 Propidium iodide staining Apoptosis (DISC) NF-kB activation (DISC) 16611992
DD TNFR1 Link FADD MTT assay Apoptosis (DISC) 8617770
DD TNFR1 Link RIP Data not shown Apoptosis (DISC) 8612133
DD TNFR1 Link RIP IKK assay NF-kB activation (DISC) 10795740
DD TNFR1 Link RIP Propidium iodide staining Apoptosis (DISC) 11002422
DD TNFR1 Link RIP Propidium iodide staining Apoptosis (DISC) NF-kB activation (DISC) 16611992
DD TNFR1 Link TRADD IKK assay NF-kB activation (DISC) 10795740
DD TNFR1 Link TRADD Propidium iodide staining Apoptosis (DISC) NF-kB activation (DISC) 16611992
DD TRADD Link DR4 Luciferase assay NF-kB activation 9430227
DD TRADD Link DR5 Luciferase assay NF-kB activation 9430227
DD TRADD Link MADD Annexin V staining, Immunoprecipitation Apoptosis inhibition, TRADD-TNFR1 interaction block 15007167
DD TRADD Link NGFR Co-Immunofluorescence staining NF-kB activation 12604596
DD TRADD Link TNFR1 IKK assay NF-kB activation (DISC) 10795740
DD TRADD Link TNFR1 Propidium iodide staining Apoptosis (DISC) NF-kB activation (DISC) 16611992
DD UNC5B Link DAPK1 Trypan blue staining, Immunoprecipitation Apoptosis, DAPK kinase activity increase 15729359
(Link: click this icon to show interactions only between the two corresponding DDs)