DED

Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vitro interaction
  DD1 DD2 Reference
Family DD1 DD2 Method Species Region Expression Species Region Expression
DED Caspase10 Link FADD GST fusion protein pull-down HuH-7 lysate Not specified Full length E.coli 12407100
DED Caspase10 Link FADD His fusion protein pull-down Human Not specified In vitro translation Not specified Not specified Not specified 9045686
DED Caspase10 Link FLIP GST fusion protein pull-down Not specified Not specified In vitro translation Human Full length Not specified 9228018
DED Caspase10 Link FLIP Yeast two-hybrid Human Full length Yeast Human 1-215 Yeast 9208847
DED Caspase10 Link FLIP Yeast two-hybrid Not specified 18-189 Yeast Human 1-160 Yeast 9228018
DED Caspase8 Link Caspase8 Yeast two-hybrid Mouse 1-202 Yeast Mouse 1-202 Yeast 10526240
DED Caspase8 Link Caspase8 Yeast two-hybrid Mouse 1-202 Yeast Mouse 82-202 Yeast 10526240
DED Caspase8 Link DEDD GST fusion protein pull-down Not specified Full length In vitro translation Human 1-318 In vitro translation 9774341
DED Caspase8 Link DEDD GST fusion protein pull-down Not specified 1-180 In vitro translation Human 1-318 In vitro translation 9774341
DED Caspase8 Link DEDD GST fusion protein pull-down Not specified 1-201 In vitro translation Not specified Full length E.coli 11965497
DED Caspase8 Link DEDD2 GST fusion protein pull-down Not specified 1-201 In vitro translation Not specified Full length E.coli 11965497
DED Caspase8 Link FADD Fluorescence resonance energy transfer ` 11717445
DED Caspase8 Link FADD GST fusion protein pull-down HuH-7 lysate Not specified Full length E.coli 12407100
DED Caspase8 Link FADD His fusion protein pull-down Not specified 1-479 In vitro translation Not specified Full length Not specified 8681377
DED Caspase8 Link FADD His fusion protein pull-down Human Not specified In vitro translation Not specified Not specified Not specified 9045686
DED Caspase8 Link FADD His fusion protein pull-down Human 1-479 In vitro translation Not specified Not specified In vitro translation 12010809
DED Caspase8 Link FADD In vitro purification protein assembly(2D gel electrophoresis) Not specified 1-479 In vitro translation Not specified Full length HEK293 8681377
DED Caspase8 Link FADD Yeast two-hybrid Human Not specified Yeast Human Full length Yeast 8681376
DED Caspase8 Link FADD Yeast two-hybrid Human Not specified Yeast Human 1-79 Yeast 8681376
DED Caspase8 Link FADD Yeast two-hybrid Mouse 1-202 Yeast Mouse 1-96 Yeast 10526240
DED Caspase8 Link FADD Yeast two-hybrid Human Full length Yeast Not specified Not specified Yeast 15782135
DED Caspase8 Link FLIP GST fusion protein pull-down Not specified 1-201 In vitro translation Human Full length Not specified 9228018
DED Caspase8 Link FLIP Yeast two-hybrid Human Full length Yeast Human 1-215 Yeast 9208847
DED Caspase8 Link FLIP Yeast two-hybrid Not specified 1-201 Yeast Human 1-160 Yeast 9228018
DED Caspase8 Link FLIP Yeast two-hybrid Not specified Not specified Yeast Human Full length Yeast 9289491
DED Caspase8 Link FLIP Yeast two-hybrid Not specified 1-480 In vitro translation Human 1-208 Not specified 9326610
DED Caspase8 Link FLIP Yeast two-hybrid Not specified 1-216 In vitro translation Human 1-180 Not specified 9326610
DED DEDD Link Caspase8 GST fusion protein pull-down Human 1-318 In vitro translation Not specified Full length In vitro translation 9774341
DED DEDD Link Caspase8 GST fusion protein pull-down Human 1-318 In vitro translation Not specified 1-180 In vitro translation 9774341
DED DEDD Link Caspase8 GST fusion protein pull-down Not specified Full length E.coli Not specified 1-201 In vitro translation 11965497
DED DEDD Link DEDD GST fusion protein pull-down Not specified Full length E.coli Not specified Full length In vitro translation 11965497
DED DEDD Link DEDD2 GST fusion protein pull-down Not specified Full length E.coli Not specified Full length In vitro translation 11965497
DED DEDD Link DEDD2 GST fusion protein pull-down Not specified Full length In vitro translation Not specified Full length E.coli 11965497
DED DEDD Link DEDD2 GST fusion protein pull-down Not specified Not specified In vitro translation Not specified 1-115 E.coli 12527898
DED DEDD Link FADD GST fusion protein pull-down Human 1-318 In vitro translation Not specified Full length In vitro translation 9774341
DED DEDD Link FADD GST fusion protein pull-down Human 1-318 In vitro translation Not specified 1-88 In vitro translation 9774341
DED DEDD Link FLIP GST fusion protein pull-down Not specified Full length E.coli Human Full length In vitro translation 11965497
DED DEDD2 Link Caspase8 GST fusion protein pull-down Not specified Full length E.coli Not specified 1-201 In vitro translation 11965497
DED DEDD2 Link DEDD GST fusion protein pull-down Not specified Full length In vitro translation Not specified Full length E.coli 11965497
DED DEDD2 Link DEDD GST fusion protein pull-down Not specified Full length E.coli Not specified Full length In vitro translation 11965497
DED DEDD2 Link DEDD GST fusion protein pull-down Not specified 1-115 E.coli Not specified Not specified In vitro translation 12527898
DED DEDD2 Link DEDD2 GST fusion protein pull-down Not specified Full length E.coli Not specified Full length In vitro translation 11965497
DED DEDD2 Link FLIP GST fusion protein pull-down Human Not specified E.coli Not specified Not specified In vitro translation 11741985
DED DEDD2 Link FLIP GST fusion protein pull-down Not specified Full length E.coli Human Full length In vitro translation 11965497
DED FADD Link Caspase10 GST fusion protein pull-down Not specified Full length E.coli HuH-7 lysate 12407100
DED FADD Link Caspase10 His fusion protein pull-down Not specified Not specified Not specified Human Not specified In vitro translation 9045686
DED FADD Link Caspase8 Fluorescence resonance energy transfer ` 11717445
DED FADD Link Caspase8 GST fusion protein pull-down Not specified Full length E.coli HuH-7 lysate 12407100
DED FADD Link Caspase8 His fusion protein pull-down Not specified Full length Not specified Not specified 1-479 In vitro translation 8681377
DED FADD Link Caspase8 His fusion protein pull-down Not specified Not specified Not specified Human Not specified In vitro translation 9045686
DED FADD Link Caspase8 His fusion protein pull-down Not specified Not specified In vitro translation Human 1-479 In vitro translation 12010809
DED FADD Link Caspase8 In vitro purification protein assembly(2D gel electrophoresis) Not specified Full length HEK293 Not specified 1-479 In vitro translation 8681377
DED FADD Link Caspase8 Yeast two-hybrid Human Full length Yeast Human Not specified Yeast 8681376
DED FADD Link Caspase8 Yeast two-hybrid Human 1-79 Yeast Human Not specified Yeast 8681376
DED FADD Link Caspase8 Yeast two-hybrid Mouse 1-96 Yeast Mouse 1-202 Yeast 10526240
DED FADD Link Caspase8 Yeast two-hybrid Not specified Not specified Yeast Human Full length Yeast 15782135
DED FADD Link DEDD GST fusion protein pull-down Not specified Full length In vitro translation Human 1-318 In vitro translation 9774341
DED FADD Link DEDD GST fusion protein pull-down Not specified 1-88 In vitro translation Human 1-318 In vitro translation 9774341
DED FADD Link FLIP GST fusion protein pull-down Not specified 1-79 In vitro translation Human Full length Not specified 9228018
DED FADD Link FLIP GST fusion protein pull-down Not specified Full length E.coli HuH-7 lysate 12407100
DED FADD Link FLIP Yeast two-hybrid Human Full length Yeast Human 1-215 Yeast 9208847
DED FADD Link FLIP Yeast two-hybrid Not specified 1-79 Yeast Human 1-160 Yeast 9228018
DED FADD Link FLIP Yeast two-hybrid Not specified Not specified Yeast Human Full length Yeast 9289491
DED FADD Link FLIP Yeast two-hybrid Not specified 1-208 In vitro translation Human 1-180 Not specified 9326610
DED FADD Link PEA15 GST fusion protein pull-down Not specified Not specified In vitro translation Not specified Not specified In vitro translation 10493725
DED FLIP Link Caspase10 GST fusion protein pull-down Human Full length Not specified Not specified Not specified In vitro translation 9228018
DED FLIP Link Caspase10 Yeast two-hybrid Human 1-215 Yeast Human Full length Yeast 9208847
DED FLIP Link Caspase10 Yeast two-hybrid Human 1-160 Yeast Not specified 18-189 Yeast 9228018
DED FLIP Link Caspase8 GST fusion protein pull-down Human Full length Not specified Not specified 1-201 In vitro translation 9228018
DED FLIP Link Caspase8 Yeast two-hybrid Human 1-215 Yeast Human Full length Yeast 9208847
DED FLIP Link Caspase8 Yeast two-hybrid Human 1-160 Yeast Not specified 1-201 Yeast 9228018
DED FLIP Link Caspase8 Yeast two-hybrid Human Full length Yeast Not specified Not specified Yeast 9289491
DED FLIP Link Caspase8 Yeast two-hybrid Human 1-208 Not specified Not specified 1-480 In vitro translation 9326610
DED FLIP Link Caspase8 Yeast two-hybrid Human 1-180 Not specified Not specified 1-216 In vitro translation 9326610
DED FLIP Link DEDD GST fusion protein pull-down Human Full length In vitro translation Not specified Full length E.coli 11965497
DED FLIP Link DEDD2 GST fusion protein pull-down Not specified Not specified In vitro translation Human Not specified E.coli 11741985
DED FLIP Link DEDD2 GST fusion protein pull-down Human Full length In vitro translation Not specified Full length E.coli 11965497
DED FLIP Link FADD GST fusion protein pull-down Human Full length Not specified Not specified 1-79 In vitro translation 9228018
DED FLIP Link FADD GST fusion protein pull-down HuH-7 lysate Not specified Full length E.coli 12407100
DED FLIP Link FADD Yeast two-hybrid Human 1-215 Yeast Human Full length Yeast 9208847
DED FLIP Link FADD Yeast two-hybrid Human 1-160 Yeast Not specified 1-79 Yeast 9228018
DED FLIP Link FADD Yeast two-hybrid Human Full length Yeast Not specified Not specified Yeast 9289491
DED FLIP Link FADD Yeast two-hybrid Human 1-180 Not specified Not specified 1-208 In vitro translation 9326610
DED FLIP Link FLIP Yeast two-hybrid Human 1-160 Yeast Human 1-160 Yeast 9228018
DED FLIP Link FLIP Yeast two-hybrid Human Full length Yeast Human Full length Yeast 9289491
DED PEA15 Link FADD GST fusion protein pull-down Not specified Not specified In vitro translation Not specified Not specified In vitro translation 10493725
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
DED Caspase10 Link Caspase8 Co-immunoprecipitation HT1080 12887920
DED Caspase10 Link Caspase8 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 12887920
DED Caspase10 Link Caspase8 Co-immunoprecipitation SKW6.4 17159907
DED Caspase10 Link Caspase8 Fluorescence resonance energy transfer Jurkat Not specified Full length Not specified Full length 11717445
DED Caspase10 Link DEDD2 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Full length 12527898
DED Caspase10 Link FADD Co-immunoprecipitation HEK293 Human Not specified Not specified Not specified 9045686
DED Caspase10 Link FADD Fluorescence resonance energy transfer HEK293 Not specified Full length Not specified Not specified 11717445
DED Caspase10 Link FLIP Co-immunoprecipitation HEK293 Not specified Not specified Human Full length 9211860
DED Caspase10 Link FLIP Co-immunoprecipitation HEK293 Not specified 18-189 Human Full length 9228018
DED Caspase10 Link FLIP Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 12887920
DED Caspase8 Link Caspase10 Co-immunoprecipitation HT1080 12887920
DED Caspase8 Link Caspase10 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 12887920
DED Caspase8 Link Caspase10 Co-immunoprecipitation SKW6.4 17159907
DED Caspase8 Link Caspase10 Fluorescence resonance energy transfer Jurkat Not specified Full length Not specified Full length 11717445
DED Caspase8 Link Caspase8 Fluorescence resonance energy transfer Jurkat Not specified Full length Not specified Full length 11717445
DED Caspase8 Link DEDD Co-immunoprecipitation HEK293 Not used Human 1-318 9774341
DED Caspase8 Link DEDD GST fusion protein pull-down HEK293 Not specified Not specified Not specified Not specified 11741985
DED Caspase8 Link DEDD2 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Full length 11965497
DED Caspase8 Link DEDD2 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Full length 12527898
DED Caspase8 Link DEDD2 Co-immunoprecipitation HEK293 Not specified Not specified Not specified 1-115 12527898
DED Caspase8 Link FADD HSC3 21525013
DED Caspase8 Link FADD Co-immunoprecipitation HEK293 Human Not specified Human Not specified 8681376
DED Caspase8 Link FADD Co-immunoprecipitation T47D Not specified Not specified Human Not specified 9582077
DED Caspase8 Link FADD Co-immunoprecipitation Jurkat A3 11432804
DED Caspase8 Link FADD Co-immunoprecipitation MCF-7 Human 1-276 Not used 12010809
DED Caspase8 Link FADD Co-immunoprecipitation HEK293 Human 2-177 Human 2-208 12220669
DED Caspase8 Link FADD Co-immunoprecipitation HT1080 12887920
DED Caspase8 Link FADD Co-immunoprecipitation HEK293 Not specified Not specified Human Full length 15701651
DED Caspase8 Link FADD Co-immunoprecipitation SKW6.4 17159907
DED Caspase8 Link FADD Co-immunoprecipitation H2009 18485876
DED Caspase8 Link FADD Co-immunoprecipitation Panc-1 18485876
DED Caspase8 Link FADD Co-immunoprecipitation HT-1080 19060883
DED Caspase8 Link FADD Co-immunoprecipitation HT-29 19524512
DED Caspase8 Link FADD Co-immunoprecipitation H2009 20547836
DED Caspase8 Link FADD Co-immunoprecipitation SH-EP 22890322
DED Caspase8 Link FADD Co-immunoprecipitation LAN-5 22890322
DED Caspase8 Link FADD Fluorescence resonance energy transfer HEK293 Not specified Full length Not specified Not specified 11717445
DED Caspase8 Link FLIP Co-immunoprecipitation HEK293 Not specified Not specified Human Full length 9208847
DED Caspase8 Link FLIP Co-immunoprecipitation HEK293 Not specified Not specified Human Full length 9211860
DED Caspase8 Link FLIP Co-immunoprecipitation HEK293 Not specified 1-201 Human Full length 9228018
DED Caspase8 Link FLIP Co-immunoprecipitation HEK293 Human Not specified Not specified Not specified 9380701
DED Caspase8 Link FLIP Co-immunoprecipitation Raji cell Not used Not specified Not specified 12215447
DED Caspase8 Link FLIP Co-immunoprecipitation HT1080 12887920
DED Caspase8 Link FLIP Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 12887920
DED Caspase8 Link FLIP Co-immunoprecipitation SKW6.4 17159907
DED Caspase8 Link PEA15 Co-immunoprecipitation HeLa Human Not specified Human Full length 10442631
DED DEDD Link Caspase8 Co-immunoprecipitation HEK293 Human 1-318 Not used 9774341
DED DEDD Link Caspase8 GST fusion protein pull-down HEK293 Not specified Not specified Not specified Not specified 11741985
DED DEDD Link DEDD Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 12527898
DED DEDD Link DEDD2 Co-immunoprecipitation HEK293 Not specified Full length Not specified Full length 11965497
DED DEDD Link DEDD2 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Full length 12527898
DED DEDD Link DEDD2 Co-immunoprecipitation HEK293 Not specified Not specified Not specified 1-115 12527898
DED DEDD Link DEDD2 Co-immunoprecipitation HEK293 Not specified Full length Not specified Full length 12527898
DED DEDD Link DEDD2 Co-immunoprecipitation HEK293 Not specified Full length Not specified 1-115 12527898
DED DEDD Link FADD Co-immunoprecipitation HEK293 Human 1-318 Not used 9774341
DED DEDD Link FADD GST fusion protein pull-down HEK293 Not specified Not specified Not specified Not specified 11741985
DED DEDD Link FLIP GST fusion protein pull-down HEK293 Not specified Not specified Not specified Not specified 11741985
DED DEDD2 Link Caspase10 Co-immunoprecipitation HEK293 Not specified Full length Not specified Not specified 12527898
DED DEDD2 Link Caspase8 Co-immunoprecipitation HEK293 Not specified Full length Not specified Not specified 11965497
DED DEDD2 Link Caspase8 Co-immunoprecipitation HEK293 Not specified Full length Not specified Not specified 12527898
DED DEDD2 Link Caspase8 Co-immunoprecipitation HEK293 Not specified 1-115 Not specified Not specified 12527898
DED DEDD2 Link DEDD Co-immunoprecipitation HEK293 Not specified Full length Not specified Full length 11965497
DED DEDD2 Link DEDD Co-immunoprecipitation HEK293 Not specified Full length Not specified Not specified 12527898
DED DEDD2 Link DEDD Co-immunoprecipitation HEK293 Not specified 1-115 Not specified Not specified 12527898
DED DEDD2 Link DEDD Co-immunoprecipitation HEK293 Not specified Full length Not specified Full length 12527898
DED DEDD2 Link DEDD Co-immunoprecipitation HEK293 Not specified 1-115 Not specified Full length 12527898
DED DEDD2 Link DEDD2 Co-immunoprecipitation HEK293 Not specified Full length Not specified Full length 12527898
DED DEDD2 Link DEDD2 Co-immunoprecipitation HEK293 Not specified Full length Not specified 1-115 12527898
DED DEDD2 Link FLIP Co-Immunofluorescence staining MCF-7 Not specified Full length Not specified Not specified 11965497
DED DEDD2 Link FLIP Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 11741985
DED DEDD2 Link FLIP Co-immunoprecipitation HEK293 Not specified Full length Human Full length 11965497
DED FADD Link Caspase10 Co-immunoprecipitation HEK293 Not specified Not specified Human Not specified 9045686
DED FADD Link Caspase10 Fluorescence resonance energy transfer HEK293 Not specified Not specified Not specified Full length 11717445
DED FADD Link Caspase8 HSC3 21525013
DED FADD Link Caspase8 Co-immunoprecipitation HEK293 Human Not specified Human Not specified 8681376
DED FADD Link Caspase8 Co-immunoprecipitation T47D Human Not specified Not specified Not specified 9582077
DED FADD Link Caspase8 Co-immunoprecipitation Jurkat A3 11432804
DED FADD Link Caspase8 Co-immunoprecipitation MCF-7 Not used Human 1-276 12010809
DED FADD Link Caspase8 Co-immunoprecipitation HEK293 Human 2-208 Human 2-177 12220669
DED FADD Link Caspase8 Co-immunoprecipitation HT1080 12887920
DED FADD Link Caspase8 Co-immunoprecipitation HEK293 Human Full length Not specified Not specified 15701651
DED FADD Link Caspase8 Co-immunoprecipitation SKW6.4 17159907
DED FADD Link Caspase8 Co-immunoprecipitation H2009 18485876
DED FADD Link Caspase8 Co-immunoprecipitation Panc-1 18485876
DED FADD Link Caspase8 Co-immunoprecipitation HT-1080 19060883
DED FADD Link Caspase8 Co-immunoprecipitation HT-29 19524512
DED FADD Link Caspase8 Co-immunoprecipitation H2009 20547836
DED FADD Link Caspase8 Co-immunoprecipitation SH-EP 22890322
DED FADD Link Caspase8 Co-immunoprecipitation LAN-5 22890322
DED FADD Link Caspase8 Fluorescence resonance energy transfer HEK293 Not specified Not specified Not specified Full length 11717445
DED FADD Link DEDD Co-immunoprecipitation HEK293 Not used Human 1-318 9774341
DED FADD Link DEDD GST fusion protein pull-down HEK293 Not specified Not specified Not specified Not specified 11741985
DED FADD Link FLIP Co-immunoprecipitation HEK293 Not specified Not specified Human 1-195 9208847
DED FADD Link FLIP Co-immunoprecipitation HEK293 Not specified Not specified Human 78-480 9208847
DED FADD Link FLIP Co-immunoprecipitation HEK293 Not specified Not specified Human Full length 9228018
DED FADD Link FLIP Co-immunoprecipitation U937 11859150
DED FADD Link FLIP Co-immunoprecipitation Raji cell Not used Not specified Not specified 12215447
DED FADD Link FLIP Co-immunoprecipitation HEK293 Human 2-208 Human 1-171 12220669
DED FADD Link FLIP Co-immunoprecipitation HEK293 Human 2-208 Human Full length 12220669
DED FADD Link PEA15 Co-immunoprecipitation HeLa Human 1-208 Human Full length 10442631
DED FADD Link PEA15 Co-immunoprecipitation LNCaP 22179576
DED FLIP Link Caspase10 Co-immunoprecipitation HEK293 Human Full length Not specified Not specified 9211860
DED FLIP Link Caspase10 Co-immunoprecipitation HEK293 Human Full length Not specified 18-189 9228018
DED FLIP Link Caspase10 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 12887920
DED FLIP Link Caspase8 Co-immunoprecipitation HEK293 Human Full length Not specified Not specified 9208847
DED FLIP Link Caspase8 Co-immunoprecipitation HEK293 Human Full length Not specified Not specified 9211860
DED FLIP Link Caspase8 Co-immunoprecipitation HEK293 Human Full length Not specified 1-201 9228018
DED FLIP Link Caspase8 Co-immunoprecipitation HEK293 Not specified Not specified Human Not specified 9380701
DED FLIP Link Caspase8 Co-immunoprecipitation Raji cell Not specified Not specified Not used 12215447
DED FLIP Link Caspase8 Co-immunoprecipitation HT1080 12887920
DED FLIP Link Caspase8 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 12887920
DED FLIP Link Caspase8 Co-immunoprecipitation SKW6.4 17159907
DED FLIP Link DEDD GST fusion protein pull-down HEK293 Not specified Not specified Not specified Not specified 11741985
DED FLIP Link DEDD2 Co-Immunofluorescence staining MCF-7 Not specified Not specified Not specified Full length 11965497
DED FLIP Link DEDD2 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 11741985
DED FLIP Link DEDD2 Co-immunoprecipitation HEK293 Human Full length Not specified Full length 11965497
DED FLIP Link FADD Co-immunoprecipitation HEK293 Human 1-195 Not specified Not specified 9208847
DED FLIP Link FADD Co-immunoprecipitation HEK293 Human 78-480 Not specified Not specified 9208847
DED FLIP Link FADD Co-immunoprecipitation HEK293 Human Full length Not specified Not specified 9228018
DED FLIP Link FADD Co-immunoprecipitation U937 11859150
DED FLIP Link FADD Co-immunoprecipitation Raji cell Not specified Not specified Not used 12215447
DED FLIP Link FADD Co-immunoprecipitation HEK293 Human 1-171 Human 2-208 12220669
DED FLIP Link FADD Co-immunoprecipitation HEK293 Human Full length Human 2-208 12220669
DED PEA15 Link Caspase8 Co-immunoprecipitation HeLa Human Full length Human Not specified 10442631
DED PEA15 Link FADD Co-immunoprecipitation HeLa Human Full length Human 1-208 10442631
DED PEA15 Link FADD Co-immunoprecipitation LNCaP 22179576
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Characterization
  Stoichiometry Affinity Protein-Protein interface Reference
Family DD1 DD2 Method Mutation Complex structure
DED Caspase8 Link FADD Co-immunoprecipitation F25G, F35V (FADD) 9582077
DED Caspase8 Link FADD Co-immunoprecipitation K33Q and K35Q, F25G (FADD) 12220669
DED FADD Link Caspase8 Co-immunoprecipitation F25G, F35V (FADD) 9582077
DED FADD Link Caspase8 Co-immunoprecipitation K33Q and K35Q, F25G (FADD) 12220669
DED FADD Link FLIP Co-immunoprecipitation K33Q and K35Q, F25G, F25Y, K33N and K35N (FADD) 12220669
DED FLIP Link FADD Co-immunoprecipitation K33Q and K35Q, F25G, F25Y, K33N and K35N (FADD) 12220669
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Functional Role
Family DD1 DD2 Method Death-related Death-unrelated Reference
DED Caspase10 Link FADD DAPI staining Apoptosis (DISC) 9045686
DED Caspase10 Link FLIP β-galactosidase staining Apoptosis inhibition 9228018
DED Caspase8 Link FADD β-galactosidase staining Apoptosis (DISC) 8681376
DED Caspase8 Link FADD DNA fragmentation assay Apoptosis (DISC) 11432804
DED Caspase8 Link FADD Propidium iodide staining Apoptosis (DISC) 12010809
DED Caspase8 Link FADD Hoechst staining Apoptosis (DISC) 12887920
DED Caspase8 Link FADD PARP cleaved assay Apoptosis (DISC) 18485876
DED Caspase8 Link FADD MTT assay Apoptosis (DISC) 22890322
DED Caspase8 Link FADD DAPI staining Apoptosis (DISC) 9045686
DED Caspase8 Link FLIP β-galactosidase staining Apoptosis inhibition 9228018
DED Caspase8 Link FLIP Confocal microscopy Apoptosis inhibition 12215447
DED Caspase8 Link PEA15 PARP cleaved assay Apoptosis inhibition 10442631
DED DEDD Link FADD Data not shown Apoptosis 9774341
DED FADD Link Caspase10 DAPI staining Apoptosis (DISC) 9045686
DED FADD Link Caspase8 β-galactosidase staining Apoptosis (DISC) 8681376
DED FADD Link Caspase8 DNA fragmentation assay Apoptosis (DISC) 11432804
DED FADD Link Caspase8 Propidium iodide staining Apoptosis (DISC) 12010809
DED FADD Link Caspase8 Hoechst staining Apoptosis (DISC) 12887920
DED FADD Link Caspase8 PARP cleaved assay Apoptosis (DISC) 18485876
DED FADD Link Caspase8 MTT assay Apoptosis (DISC) 22890322
DED FADD Link Caspase8 DAPI staining Apoptosis (DISC) 9045686
DED FADD Link DEDD Data not shown Apoptosis 9774341
DED FADD Link FLIP β-galactosidase staining Apoptosis inhibition 9208847
DED FADD Link FLIP Annexin V staining Apoptosis inhibition 11859150
DED FADD Link FLIP Confocal microscopy Apoptosis inhibition 12215447
DED FADD Link PEA15 DAPI, Annexin V staining, TUNEL assay Apoptosis inhibition 10493725
DED FLIP Link Caspase10 β-galactosidase staining Apoptosis inhibition 9228018
DED FLIP Link Caspase8 β-galactosidase staining Apoptosis inhibition 9228018
DED FLIP Link Caspase8 Confocal microscopy Apoptosis inhibition 12215447
DED FLIP Link FADD β-galactosidase staining Apoptosis inhibition 9208847
DED FLIP Link FADD Annexin V staining Apoptosis inhibition 11859150
DED FLIP Link FADD Confocal microscopy Apoptosis inhibition 12215447
DED PEA15 Link Caspase8 PARP cleaved assay Apoptosis inhibition 10442631
DED PEA15 Link FADD DAPI, Annexin V staining, TUNEL assay Apoptosis inhibition 10493725
(Link: click this icon to show interactions only between the two corresponding DDs)