AIM2 (PYD)

Full Name:
Interferon-inducible protein AIM2
Alternative Names:
PYHIN4
Function:
Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.
Death Domain Subfamily & Boundary Region:
Species External DB Questionmark
Uniprot DIP STRING KEGG IntAct MINT
Human Seq O14862external db link O14862external db link hsa:9447external db link
Mouse Seq Q91VJ1external db link Q91VJ1external db link mmu:383619external db link
Not solved yet
No information
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vitro interaction
  DD1 DD2 Reference
Family DD1 DD2 Method Species Region Expression Species Region Expression
PYD AIM2 Link AIM2 In vitro purification protein assembly(chemical crosslinking) Human Full length Not specified Human Full length Not specified 19158676
PYD AIM2 Link ASC GST fusion protein pull-down Human Full length Not specified Human Full length Not specified 19158676
PYD AIM2 Link ASC GST fusion protein pull-down Human Full length Not specified Human Not specified Not specified 19158676
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
PYD AIM2 Link ASC Co-immunoprecipitation HEK293 Human 1-83 Human Not specified 19158675
PYD AIM2 Link ASC Co-immunoprecipitation THP-1 19158676
PYD AIM2 Link ASC Co-immunoprecipitation HMVEC-d 21575908
PYD AIM2 Link ASC Co-immunoprecipitation NPC TW02 Human Full length Human Full length 22869553
PYD AIM2 Link ASC Fluorescence resonance energy transfer HEK293 Human Full length Human Not specified 19158675
PYD AIM2 Link ASC Fluorescence resonance energy transfer HEK293 Human 1-83 Human Not specified 19158675
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Functional Role
Family DD1 DD2 Method Death-related Death-unrelated Reference
PYD AIM2 Link ASC Luciferase assay NF-kB activation (Inflammasome) 19158675
PYD AIM2 Link ASC Caspase cleaved assay Caspase1 activation (Inflammasome) 19158676
(Link: click this icon to show interactions only between the two corresponding DDs)