Bcl-10 (CARD)

Full Name:
B-cell lymphoma/leukemia 10
Alternative Names:
CLAP, mE10, CIPER, c-E10, CARMEN, BCL10
Function:
Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1.
Death Domain Subfamily & Boundary Region:
Species External DB Questionmark
Uniprot DIP STRING KEGG IntAct MINT
Human Seq O95999external db link DIP-29740Nexternal db link O95999external db link hsa:8915external db link O95999external db link MINT-89139external db link
Mouse Seq Q9Z0H7external db link Q9Z0H7external db link
Rat Seq Q9QYN5external db link Q9QYN5external db link rno:83477external db link
Dog Seq E2RA73external db link cfa:490183external db link
Zebra fish Seq E7F8A6external db link dre:100334750external db link
Not solved yet
Disease Mutation in disease Reference
Colonic carcinoma 45fs 9989495
Follicular lymphoma 143fs, 77fs, 137fs, 133fs 9989495
Germ cell tumor R58G, S218F, 167fs, 91X, A20T, 58X 9989495
MALT lymphoma 167fs, I32V, R49G, T100S, 55fs, 115fs 9989495
Mesothelioma 167fs, D80N, 43fs, T52I 9989495
Sezary syndrome 143fs 9989495
T cell acute lymphocytic leukemia 46fs 9989495
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vitro interaction
  DD1 DD2 Reference
Family DD1 DD2 Method Species Region Expression Species Region Expression
CARD Bcl-10 Link BinCARD GST fusion protein pull-down Not specified Not specified E.coli Human Not specified In vitro translation 15637807
CARD Bcl-10 Link CARD10 GST fusion protein pull-down Not specified Not specified E.coli Human Not specified In vitro translation 11259443
CARD Bcl-10 Link CARD10 Two-hybrid Not specified 1-104 HEK293 Human 1-138 HEK293 11259443
CARD Bcl-10 Link CARD11 GST fusion protein pull-down Not specified Not specified E.coli Not specified 1-126 In vitro translation 11278692
CARD Bcl-10 Link CARD11 In vitro purification protein assembly(chemical crosslinking) Mouse Not specified E.coli Mouse 1-160 E.coli 20439115
CARD Bcl-10 Link CARD11 Two-hybrid Not specified Not specified HEK293 Not specified 1-126 HEK293 11278692
CARD Bcl-10 Link CARD14 GST fusion protein pull-down Not specified Not specified E.coli Not specified 1-118 In vitro translation 11278692
CARD Bcl-10 Link CARD14 Two-hybrid Not specified Not specified HEK293 Not specified 1-118 HEK293 11278692
CARD Bcl-10 Link CARD9 GST fusion protein pull-down Herpesvirus2 Not specified E.coli Human Full length In vitro translation 11053425
CARD Bcl-10 Link CARD9 Two-hybrid Not specified 1-104 HEK293 Human 1-110 HEK293 11053425
CARD Bcl-10 Link RAIDD Two-hybrid Not specified Not specified HEK293 Not specified Not specified HEK293 22323537
(Link: click this icon to show interactions only between the two corresponding DDs)
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In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
CARD Bcl-10 Link Bcl-10 Co-immunoprecipitation HEK293 Human Full length Human Full length 10364242
CARD Bcl-10 Link Bcl-10 Co-immunoprecipitation HEK293 Human Full length Human 1-104 10364242
CARD Bcl-10 Link Bcl-10 Co-immunoprecipitation HEK293 Not specified Full length Human Full length 14638696
CARD Bcl-10 Link Bcl-10 Co-immunoprecipitation HEK293 Not specified 1-127 Not specified 1-127 19538180
CARD Bcl-10 Link Bcl-10 GST fusion protein pull-down HEK293 Human Full length Human Full length 10187815
CARD Bcl-10 Link BinCARD Co-Immunofluorescence staining HeLa Not specified Not specified Human Not specified 15637807
CARD Bcl-10 Link BinCARD Co-immunoprecipitation HEK293 Not specified Not specified Human Not specified 15637807
CARD Bcl-10 Link CARD10 Co-immunoprecipitation HEK293 Not specified Not specified Human Not specified 11259443
CARD Bcl-10 Link CARD10 Co-immunoprecipitation HEK293 Not used Human Not specified 11259443
CARD Bcl-10 Link CARD10 Co-immunoprecipitation HEK293 Not specified Not specified Human 1-116 11387339
CARD Bcl-10 Link CARD10 Co-immunoprecipitation HEK293 Not specified 1-127 Not specified Not specified 19538180
CARD Bcl-10 Link CARD11 Co-Immunofluorescence staining HeLa Human 2-233 Human 1-153 11356195
CARD Bcl-10 Link CARD11 Co-immunoprecipitation HEK293 Not used Not specified 1-126 11278692
CARD Bcl-10 Link CARD11 Co-immunoprecipitation HEK293 Human 2-233 Human 1-153 11356195
CARD Bcl-10 Link CARD11 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 12154360
CARD Bcl-10 Link CARD11 Co-immunoprecipitation HEK293 Mouse Not specified Human 1-470 16809782
CARD Bcl-10 Link CARD11 Co-immunoprecipitation Jurkat 16818229
CARD Bcl-10 Link CARD11 Co-immunoprecipitation DO11.10 17478723
CARD Bcl-10 Link CARD11 Co-immunoprecipitation DT40 Not used Not specified Not specified 18086859
CARD Bcl-10 Link CARD11 Co-immunoprecipitation DO11.10 18802088
CARD Bcl-10 Link CARD11 Co-immunoprecipitation Jurkat 19444310
CARD Bcl-10 Link CARD11 Co-immunoprecipitation DLBCL 19841089
CARD Bcl-10 Link CARD11 Co-immunoprecipitation Jurkat 21157432
CARD Bcl-10 Link CARD11 Co-immunoprecipitation Jurkat 21199863
CARD Bcl-10 Link CARD12 Co-immunoprecipitation HEK293 Not specified Not specified Human Not specified 11472070
CARD Bcl-10 Link CARD14 Co-immunoprecipitation HEK293 Not used Not specified 1-118 11278692
CARD Bcl-10 Link CARD9 Co-Immunofluorescence staining Rat-1 cell Herpesvirus2 Full length Human Full length 11053425
CARD Bcl-10 Link CARD9 Co-immunoprecipitation HEK293 Herpesvirus2 Not specified Human Full length 11053425
CARD Bcl-10 Link CARD9 Co-immunoprecipitation HEK293 11053425
CARD Bcl-10 Link CARD9 Co-immunoprecipitation Bone marrow derived macrophage 20538615
CARD Bcl-10 Link CARD9 Co-immunoprecipitation THP-1 20538615
CARD Bcl-10 Link CARMA1 Co-immunoprecipitation HEK293 Mouse 1-121 Mouse 1-155 22880103
CARD Bcl-10 Link CIAP2 Co-immunoprecipitation Rat brain hippocampus 12786973
CARD Bcl-10 Link CIAP2 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 16775419
CARD Bcl-10 Link RAIDD Co-immunoprecipitation HEK293 Not specified Not specified Not used 22323537
CARD Bcl-10 Link RIPK2 Co-immunoprecipitation HEK293 Human Full length Not specified Full length 14638696
CARD Bcl-10 Link RIPK2 Co-immunoprecipitation HEK293 Not specified Full length Human Full length 14638696
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Characterization
  Stoichiometry Affinity Protein-Protein interface Reference
Family DD1 DD2 Method Mutation Complex structure
CARD Bcl-10 Link Bcl-10 Co-immunoprecipitation L41R(Bcl-10) 10364242
CARD Bcl-10 Link Bcl-10 Fluorescence probe labeling 3.0μM 19538180
CARD Bcl-10 Link Bcl-10 GST fusion protein pull-down L47A, I46A, L41A, I55A (Bcl-10) 10187815
CARD Bcl-10 Link BinCARD GST fusion protein pull-down L65A (BinCARD) 15637807
CARD Bcl-10 Link CARD11 Co-immunoprecipitation L39R (CARD11) 12154360
CARD Bcl-10 Link CARD11 Co-immunoprecipitation S109A (CARD11) 16809782
CARD Bcl-10 Link CARMA1 Co-immunoprecipitation R35A (CARMA1) E53A, E54A (Bcl-10) 22880103
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Functional Role
Family DD1 DD2 Method Death-related Death-unrelated Reference
CARD Bcl-10 Link Bcl-10 Luciferase assay NF-kB activation 10364242
CARD Bcl-10 Link BinCARD Luciferase assay NF-kB activation block 15637807
CARD Bcl-10 Link CARD10 Luciferase assay NF-kB activation (signalosome) 11259443
CARD Bcl-10 Link CARD10 Luciferase assay NF-kB activation (signalosome) 11387339
CARD Bcl-10 Link CARD11 Luciferase assay Bcl10 phosphorylation, NF-kB activation (Signalosome) 11356195
CARD Bcl-10 Link CARD11 Luciferase assay NF-kB activation (signalosome) 11278692
CARD Bcl-10 Link CARD11 Luciferase assay NF-kB activation (Signalosome) 12154360
CARD Bcl-10 Link CARD11 Luciferase assay NF-kB activation (Signalosome) 16809782
CARD Bcl-10 Link CARD11 Immunofluorescence staining NF-kB activation (Signalosome) 17478723
CARD Bcl-10 Link CARD11 Immunofluorescence staining NF-kB activation (Signalosome) 18802088
CARD Bcl-10 Link CARD14 Luciferase assay NF-kB activation (signalosome) 11278692
CARD Bcl-10 Link CARD9 Luciferase assay NF-kB activation (signalosome) 11053425
CARD Bcl-10 Link CARD9 EMSA NF-kB activation (Signalosome) 20538615
CARD Bcl-10 Link RAIDD Immunoprecipitation Bcl10-CARMA1 complex inhibition 22323537
CARD Bcl-10 Link RIPK2 Luciferase assay NF-kB activation 14638696
(Link: click this icon to show interactions only between the two corresponding DDs)