BinCARD (CARD)

Full Name:
Bcl10-interacting CARD protein
Alternative Names:
C9orf89, MGC11115, MGC110898, bA370F5.1
Function:
Plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B. May inhibit the phosphorylation of BCL10 in a CARD-dependent manner.
Death Domain Subfamily & Boundary Region:
Species External DB Questionmark
Uniprot DIP STRING KEGG IntAct MINT
Human Seq Q96LW7external db link DIP-42406Nexternal db link Q96LW7external db link hsa:84270external db link MINT-1215062external db link
Mouse Seq Q9D1I2external db link mmu:68480external db link
Not solved yet
No information
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vitro interaction
  DD1 DD2 Reference
Family DD1 DD2 Method Species Region Expression Species Region Expression
CARD BinCARD Link Bcl-10 GST fusion protein pull-down Human Not specified In vitro translation Not specified Not specified E.coli 15637807
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
CARD BinCARD Link Bcl-10 Co-Immunofluorescence staining HeLa Human Not specified Not specified Not specified 15637807
CARD BinCARD Link Bcl-10 Co-immunoprecipitation HEK293 Human Not specified Not specified Not specified 15637807
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Characterization
  Stoichiometry Affinity Protein-Protein interface Reference
Family DD1 DD2 Method Mutation Complex structure
CARD BinCARD Link Bcl-10 GST fusion protein pull-down L65A (BinCARD) 15637807
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Functional Role
Family DD1 DD2 Method Death-related Death-unrelated Reference
CARD BinCARD Link Bcl-10 Luciferase assay NF-kB activation block 15637807
(Link: click this icon to show interactions only between the two corresponding DDs)