CARD10 (CARD)

Full Name:
Caspase recruitment domain-containing protein 10
Alternative Names:
BIMP1, CARMA3, MGC142219
Function:
Activates NF-kappa-B via BCL10 and IKK.
Death Domain Subfamily & Boundary Region:
Species External DB Questionmark
Uniprot DIP STRING KEGG IntAct MINT
Human Seq Q9BWT7external db link DIP-41908Nexternal db link Q9BWT7external db link hsa:29775external db link MINT-192132external db link
Mouse Seq P58660external db link P58660external db link mmu:105844external db link
Rat Seq D4A425external db link rno:315120external db link
Dog Seq F1PGC2external db link
Zebra fish Seq E7F8I7external db link
Not solved yet
No information
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vitro interaction
  DD1 DD2 Reference
Family DD1 DD2 Method Species Region Expression Species Region Expression
CARD CARD10 Link Bcl-10 GST fusion protein pull-down Human Not specified In vitro translation Not specified Not specified E.coli 11259443
CARD CARD10 Link Bcl-10 Two-hybrid Human 1-138 HEK293 Not specified 1-104 HEK293 11259443
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
CARD CARD10 Link Bcl-10 Co-immunoprecipitation HEK293 Human Not specified Not specified Not specified 11259443
CARD CARD10 Link Bcl-10 Co-immunoprecipitation HEK293 Human Not specified Not used 11259443
CARD CARD10 Link Bcl-10 Co-immunoprecipitation HEK293 Human 1-116 Not specified Not specified 11387339
CARD CARD10 Link Bcl-10 Co-immunoprecipitation HEK293 Not specified Not specified Not specified 1-127 19538180
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Functional Role
Family DD1 DD2 Method Death-related Death-unrelated Reference
CARD CARD10 Link Bcl-10 Luciferase assay NF-kB activation (signalosome) 11259443
CARD CARD10 Link Bcl-10 Luciferase assay NF-kB activation (signalosome) 11387339
(Link: click this icon to show interactions only between the two corresponding DDs)