CARD11 (CARD)

Full Name:
Caspase recruitment domain-containing protein 11
Alternative Names:
BIMP3, CARMA1, MGC133069
Function:
Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10.
Death Domain Subfamily & Boundary Region:
Species External DB Questionmark
Uniprot DIP STRING KEGG IntAct MINT
Human Seq Q9BXL7external db link DIP-41797Nexternal db link Q9BXL7external db link hsa:84433external db link MINT-193901external db link
Mouse Seq Q8CIS0external db link Q8CIS0external db link mmu:108723external db link Q8CIS0external db link
Dog Seq F1PZC8external db link
Zebra fish Seq E7FB52external db link
Not solved yet
No information
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vitro interaction
  DD1 DD2 Reference
Family DD1 DD2 Method Species Region Expression Species Region Expression
CARD CARD11 Link Bcl-10 GST fusion protein pull-down Not specified 1-126 In vitro translation Not specified Not specified E.coli 11278692
CARD CARD11 Link Bcl-10 In vitro purification protein assembly(chemical crosslinking) Mouse 1-160 E.coli Mouse Not specified E.coli 20439115
CARD CARD11 Link Bcl-10 Two-hybrid Not specified 1-126 HEK293 Not specified Not specified HEK293 11278692
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
CARD CARD11 Link Bcl-10 Co-Immunofluorescence staining HeLa Human 1-153 Human 2-233 11356195
CARD CARD11 Link Bcl-10 Co-immunoprecipitation HEK293 Not specified 1-126 Not used 11278692
CARD CARD11 Link Bcl-10 Co-immunoprecipitation HEK293 Human 1-153 Human 2-233 11356195
CARD CARD11 Link Bcl-10 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 12154360
CARD CARD11 Link Bcl-10 Co-immunoprecipitation HEK293 Human 1-470 Mouse Not specified 16809782
CARD CARD11 Link Bcl-10 Co-immunoprecipitation Jurkat 16818229
CARD CARD11 Link Bcl-10 Co-immunoprecipitation DO11.10 17478723
CARD CARD11 Link Bcl-10 Co-immunoprecipitation DT40 Not specified Not specified Not used 18086859
CARD CARD11 Link Bcl-10 Co-immunoprecipitation DO11.10 18802088
CARD CARD11 Link Bcl-10 Co-immunoprecipitation Jurkat 19444310
CARD CARD11 Link Bcl-10 Co-immunoprecipitation DLBCL 19841089
CARD CARD11 Link Bcl-10 Co-immunoprecipitation Jurkat 21157432
CARD CARD11 Link Bcl-10 Co-immunoprecipitation Jurkat 21199863
CARD CARD11 Link CARD11 Co-immunoprecipitation HEK293 Murine 2-1159 Murine 2-1159 18625728
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Characterization
  Stoichiometry Affinity Protein-Protein interface Reference
Family DD1 DD2 Method Mutation Complex structure
CARD CARD11 Link Bcl-10 Co-immunoprecipitation L39R (CARD11) 12154360
CARD CARD11 Link Bcl-10 Co-immunoprecipitation S109A (CARD11) 16809782
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Functional Role
Family DD1 DD2 Method Death-related Death-unrelated Reference
CARD CARD11 Link Bcl-10 Luciferase assay Bcl10 phosphorylation, NF-kB activation (Signalosome) 11356195
CARD CARD11 Link Bcl-10 Luciferase assay NF-kB activation (signalosome) 11278692
CARD CARD11 Link Bcl-10 Luciferase assay NF-kB activation (Signalosome) 12154360
CARD CARD11 Link Bcl-10 Luciferase assay NF-kB activation (Signalosome) 16809782
CARD CARD11 Link Bcl-10 Immunofluorescence staining NF-kB activation (Signalosome) 17478723
CARD CARD11 Link Bcl-10 Immunofluorescence staining NF-kB activation (Signalosome) 18802088
(Link: click this icon to show interactions only between the two corresponding DDs)