CARD12 (CARD)

Full Name:
NLR family CARD domain-containing protein 4
Alternative Names:
CLAN, IPAF, CLAN1, CLANA, CLANB, CLANC, CLAND, CLR2.1, NLRC4
Function:
Plays a role in the promotion of apoptosis.
Death Domain Subfamily & Boundary Region:
Species External DB Questionmark
Uniprot DIP STRING KEGG IntAct MINT
Human Seq Q9NPP4external db link DIP-38428Nexternal db link Q9NPP4external db link hsa:58484external db link Q9NPP4external db link MINT-201147external db link
Mouse Seq Q3UP24external db link Q3UP24external db link mmu:268973external db link
Rat Seq D3ZA97external db link
Not solved yet
No information
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vitro interaction
  DD1 DD2 Reference
Family DD1 DD2 Method Species Region Expression Species Region Expression
CARD CARD12 Link ASC GST fusion protein pull-down Human 1-88 E.coli Human 105-195 In vitro translation 11967258
CARD CARD12 Link ASC GST fusion protein pull-down Human 1-88 E.coli Human Full length In vitro translation 11967258
CARD CARD12 Link ASC Two-hybrid Not specified 1-83 HEK293 Not specified Not specified HEK293 11374873
CARD CARD12 Link ASC Yeast two-hybrid Human 1-96 Yeast Human Full length Yeast 19337385
CARD CARD12 Link CARD12 GST fusion protein pull-down Not specified Full length Not specified Not specified 1-88 Not specified 11390368
CARD CARD12 Link CARD12 Two-hybrid Not specified 1-83 HEK293 Not specified 1-83 HEK293 11374873
CARD CARD12 Link Caspase1 GST fusion protein pull-down Not specified 1-88 Not specified Not specified Full length Not specified 11390368
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
CARD CARD12 Link ASC Co-immunoprecipitation HEK293 Not specified 1-647 Not specified Full length 12646168
CARD CARD12 Link ASC Co-immunoprecipitation HEK293 Human 1-457 Human Not specified 15701651
CARD CARD12 Link Bcl-10 Co-immunoprecipitation HEK293 Human Not specified Not specified Not specified 11472070
CARD CARD12 Link CARD12 Co-immunoprecipitation HEK293 Not specified Full length Not specified Full length 11390368
CARD CARD12 Link CARD12 Co-immunoprecipitation HEK293 Not specified Full length Not specified 1-88 11390368
CARD CARD12 Link CARD12 Co-immunoprecipitation HEK293 Human Not specified Human Not specified 11472070
CARD CARD12 Link Caspase1 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 11374873
CARD CARD12 Link Caspase1 Co-immunoprecipitation HEK293 Not specified Full length Human Full length 11390368
CARD CARD12 Link Caspase1 Co-immunoprecipitation HEK293 Not specified 1-88 Human 1-94 11390368
CARD CARD12 Link Caspase1 Co-immunoprecipitation HEK293 Human Not specified Not specified Not specified 11472070
CARD CARD12 Link Caspase1 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 17418785
CARD CARD12 Link NLRP1 Co-immunoprecipitation HEK293 Human Not specified Not specified Not specified 11472070
CARD CARD12 Link NOD2 Co-immunoprecipitation HEK293 Human Not specified Not specified Not specified 11472070
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Functional Role
Family DD1 DD2 Method Death-related Death-unrelated Reference
CARD CARD12 Link ASC β-galactosidase staining, Luciferase assay Apoptosis NF-kB activation 12646168
CARD CARD12 Link Caspase1 β-galactosidase staining Pyroptosis (Inflammasome) 11390368
(Link: click this icon to show interactions only between the two corresponding DDs)