CARD14 (CARD)

Full Name:
Caspase recruitment domain-containing protein 14
Alternative Names:
BIMP2, CARMA2
Function:
Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10.
Death Domain Subfamily & Boundary Region:
Species External DB Questionmark
Uniprot DIP STRING KEGG IntAct MINT
Human Seq Q9BXL6external db link DIP-41861Nexternal db link Q9BXL6external db link hsa:79092external db link Q9BXL6external db link MINT-193865external db link
Mouse Seq Q99KF0external db link Q99KF0external db link mmu:170720external db link
Dog Seq E2QUR3external db link
Zebra fish Seq E9QBP2external db link
Not solved yet
No information
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vitro interaction
  DD1 DD2 Reference
Family DD1 DD2 Method Species Region Expression Species Region Expression
CARD CARD14 Link Bcl-10 GST fusion protein pull-down Not specified 1-118 In vitro translation Not specified Not specified E.coli 11278692
CARD CARD14 Link Bcl-10 Two-hybrid Not specified 1-118 HEK293 Not specified Not specified HEK293 11278692
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
CARD CARD14 Link Bcl-10 Co-immunoprecipitation HEK293 Not specified 1-118 Not used 11278692
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Functional Role
Family DD1 DD2 Method Death-related Death-unrelated Reference
CARD CARD14 Link Bcl-10 Luciferase assay NF-kB activation (signalosome) 11278692
(Link: click this icon to show interactions only between the two corresponding DDs)