CARD17 (CARD)

Full Name:
Caspase recruitment domain-containing protein 17
Alternative Names:
INCA
Function:
Regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-IL-1beta/IL1B and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. However, unlike CASP1, do not induce NF-kappa-B activation.
Death Domain Subfamily & Boundary Region:
Species External DB Questionmark
Uniprot DIP STRING KEGG IntAct MINT
Human Seq Q5XLA6external db link hsa:440068external db link
Not solved yet
No information
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
CARD CARD17 Link CARD16 Co-immunoprecipitation HEK293 Human Not specified Human 1-106 15383541
CARD CARD17 Link CARD17 Co-immunoprecipitation HEK293 Human Not specified Human Not specified 15383541
CARD CARD17 Link CARD18 Co-immunoprecipitation HEK293 Human Not specified Human Full length 15383541
CARD CARD17 Link Caspase1 Co-immunoprecipitation HEK293 Human Not specified Not specified Not specified 15383541
(Link: click this icon to show interactions only between the two corresponding DDs)