CARD18 (CARD)

Full Name:
Caspase recruitment domain-containing protein 18
Alternative Names:
ICEBERG, UNQ5804
Function:
Inhibits generation of IL-1-beta by interacting with caspase-1 and preventing its association with RIP2. Down-regulates the release of IL1B.
Death Domain Subfamily & Boundary Region:
Species External DB Questionmark
Uniprot DIP STRING KEGG IntAct MINT
Human Seq P57730external db link DIP-41317Nexternal db link hsa:59082external db link
Structure Species Residue Method Expression Purification Column Final condition Final concentration Reference
1DGN Download Human 1-92 NMR E.coli gel filtrationSephacryl S100 0.18mg/ml 11051551
No information
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vitro interaction
  DD1 DD2 Reference
Family DD1 DD2 Method Species Region Expression Species Region Expression
CARD CARD18 Link CARD16 GST fusion protein pull-down Human Full length In vitro translation Human 1-106 E.coli 11536016
CARD CARD18 Link CARD8 GST fusion protein pull-down Not specified Not specified In vitro translation Not specified Full length E.coli 11821383
CARD CARD18 Link Caspase1 GST fusion protein pull-down Human Full length E.coli Not specified Not specified In vitro translation 11536016
CARD CARD18 Link Caspase1 In vitro purification protein assembly(immunoprecipitation) Not specified Full length E.coli Not specified 1-92 E.coli 11051551
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
CARD CARD18 Link CARD16 Co-immunoprecipitation HEK293 Human Full length Human 1-106 11536016
CARD CARD18 Link CARD17 Co-immunoprecipitation HEK293 Human Full length Human Not specified 15383541
CARD CARD18 Link Caspase1 Co-immunoprecipitation HEK293 Human Full length Not specified Not specified 11536016
CARD CARD18 Link RIPK2 Co-immunoprecipitation HEK293 Human Full length Not specified Not specified 11536016
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Functional Role
Family DD1 DD2 Method Death-related Death-unrelated Reference
CARD CARD18 Link Caspase1 Immunoprecipitation Caspase1-RIPK2 complex interfere 11536016
CARD CARD18 Link Caspase1 Caspase1 binding assay RIPK2 ability inhibition 11051551
(Link: click this icon to show interactions only between the two corresponding DDs)