CARD9 (CARD)

Full Name:
Caspase recruitment domain-containing protein 9
Alternative Names:
CANDF2, hCARD9
Function:
Activates NF-kappa-B via BCL10.
Death Domain Subfamily & Boundary Region:
Species External DB Questionmark
Uniprot DIP STRING KEGG IntAct MINT
Human Seq Q9H257external db link Q9H257external db link hsa:64170external db link Q9H257external db link
Mouse Seq A2AIV8external db link A2AIV8external db link
Rat Seq Q9EPY0external db link Q9EPY0external db link rno:64171external db link
Dog Seq E2R2U9external db link
Zebra fish Seq A2CE85external db link A2CE85external db link dre:796425external db link
Not solved yet
Disease Mutation in disease Reference
Chronic mucocutaneous candidiasis Q295X 19864672
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vitro interaction
  DD1 DD2 Reference
Family DD1 DD2 Method Species Region Expression Species Region Expression
CARD CARD9 Link Bcl-10 GST fusion protein pull-down Human Full length In vitro translation Herpesvirus2 Not specified E.coli 11053425
CARD CARD9 Link Bcl-10 Two-hybrid Human 1-110 HEK293 Not specified 1-104 HEK293 11053425
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
CARD CARD9 Link Bcl-10 Co-Immunofluorescence staining Rat-1 cell Human Full length Herpesvirus2 Full length 11053425
CARD CARD9 Link Bcl-10 Co-immunoprecipitation HEK293 Human Full length Herpesvirus2 Not specified 11053425
CARD CARD9 Link Bcl-10 Co-immunoprecipitation HEK293 11053425
CARD CARD9 Link Bcl-10 Co-immunoprecipitation Bone marrow derived macrophage 20538615
CARD CARD9 Link Bcl-10 Co-immunoprecipitation THP-1 20538615
CARD CARD9 Link CARD9 Co-immunoprecipitation HEK293 Human Full length Human Full length 11053425
CARD CARD9 Link RIPK2 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 17486093
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Functional Role
Family DD1 DD2 Method Death-related Death-unrelated Reference
CARD CARD9 Link Bcl-10 Luciferase assay NF-kB activation (signalosome) 11053425
CARD CARD9 Link Bcl-10 EMSA NF-kB activation (Signalosome) 20538615
CARD CARD9 Link RIPK2 Western blotting Bcl-10 phosphorylation increase 17486093
(Link: click this icon to show interactions only between the two corresponding DDs)