CARD

Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vitro interaction
  DD1 DD2 Reference
Family DD1 DD2 Method Species Region Expression Species Region Expression
CARD Apaf1 Link Apaf1 In vitro purification protein assembly(Size-exclusion chromatography) Not specified Not specified Not specified Not specified Not specified Not specified 10944114
CARD Apaf1 Link Caspase9 GST fusion protein pull-down Not specified 1-97 E.coli Not specified Not specified In vitro translation 9390557
CARD Apaf1 Link Caspase9 GST fusion protein pull-down Not specified 1-97 E.coli Not specified Not specified In vitro translation 9922454
CARD Apaf1 Link Caspase9 GST fusion protein pull-down Not specified 1-420 In vitro translation Not specified Not specified E.coli 11408476
CARD Apaf1 Link Caspase9 GST fusion protein pull-down Not specified Not specified E.coli Not specified Not specified In vitro translation 11821383
CARD Apaf1 Link Caspase9 GST fusion protein pull-down Human THP-1 lysate Not specified 1-130 E.coli 14993223
CARD Apaf1 Link Caspase9 GST fusion protein pull-down Not specified Not specified E.coli Not specified D32cell lysate 15542838
CARD Apaf1 Link Caspase9 GST fusion protein pull-down Not specified D32cell lysate Not specified Not specified E.coli 15542838
CARD Apaf1 Link Caspase9 In vitro purification protein assembly(Size-exclusion chromatography) Human Full length HeLa Not specified Full length HeLa 10206961
CARD Apaf1 Link Caspase9 In vitro purification protein assembly(Size-exclusion chromatography) Human 1-97 E.coli Human 1-112 E.coli 10376594
CARD Apaf1 Link Caspase9 In vitro purification protein assembly(Size-exclusion chromatography) Not specified THP-1 lysate Not specified THP-1 lysate 11230124
CARD Apaf1 Link Caspase9 In vitro purification protein assembly(Size-exclusion chromatography) Not specified 1-97 E.coli Not specified Full length E.coli 11904389
CARD Apaf1 Link Caspase9 In vitro purification protein assembly(Size-exclusion chromatography) Not specified 1-97 E.coli Not specified 1-132 E.coli 11904389
CARD Apaf1 Link Caspase9 In vitro purification protein assembly(Size-exclusion chromatography) Not specified Not specified E.coli Not specified Not specified E.coli 19494828
CARD Apaf1 Link Caspase9 Yeast two-hybrid Human 1-92 Yeast Human 1-97 Yeast 19337385
CARD Apaf1 Link NLRP1 GST fusion protein pull-down Not specified Not specified In vitro translation Not specified Not specified E.coli 11113115
CARD ASC Link ASC GST fusion protein pull-down Not specified Not specified E.coli Not specified Not specified In vitro translation 14634131
CARD ASC Link ASC Yeast two-hybrid Human 105-195 Yeast Human 105-195 Yeast 19337385
CARD ASC Link CARD12 GST fusion protein pull-down Human 105-195 In vitro translation Human 1-88 E.coli 11967258
CARD ASC Link CARD12 GST fusion protein pull-down Human Full length In vitro translation Human 1-88 E.coli 11967258
CARD ASC Link CARD12 Two-hybrid Not specified Not specified HEK293 Not specified 1-83 HEK293 11374873
CARD ASC Link CARD12 Yeast two-hybrid Human Full length Yeast Human 1-96 Yeast 19337385
CARD ASC Link CARD16 GST fusion protein pull-down Human 105-195 In vitro translation Human Full length E.coli 11967258
CARD ASC Link CARD16 GST fusion protein pull-down Human Full length In vitro translation Human Full length E.coli 11967258
CARD ASC Link Caspase1 GST fusion protein pull-down Human 105-195 In vitro translation Not specified Not specified E.coli 11967258
CARD ASC Link Caspase1 GST fusion protein pull-down Human Full length In vitro translation Not specified Not specified E.coli 11967258
CARD ASC Link Caspase1 GST fusion protein pull-down Not specified Not specified E.coli Not specified Not specified In vitro translation 14634131
CARD ASC Link Caspase1 Yeast two-hybrid Human 105-195 Yeast Human 1-91 Yeast 19337385
CARD Bcl-10 Link BinCARD GST fusion protein pull-down Not specified Not specified E.coli Human Not specified In vitro translation 15637807
CARD Bcl-10 Link CARD10 GST fusion protein pull-down Not specified Not specified E.coli Human Not specified In vitro translation 11259443
CARD Bcl-10 Link CARD10 Two-hybrid Not specified 1-104 HEK293 Human 1-138 HEK293 11259443
CARD Bcl-10 Link CARD11 GST fusion protein pull-down Not specified Not specified E.coli Not specified 1-126 In vitro translation 11278692
CARD Bcl-10 Link CARD11 In vitro purification protein assembly(chemical crosslinking) Mouse Not specified E.coli Mouse 1-160 E.coli 20439115
CARD Bcl-10 Link CARD11 Two-hybrid Not specified Not specified HEK293 Not specified 1-126 HEK293 11278692
CARD Bcl-10 Link CARD14 GST fusion protein pull-down Not specified Not specified E.coli Not specified 1-118 In vitro translation 11278692
CARD Bcl-10 Link CARD14 Two-hybrid Not specified Not specified HEK293 Not specified 1-118 HEK293 11278692
CARD Bcl-10 Link CARD9 GST fusion protein pull-down Herpesvirus2 Not specified E.coli Human Full length In vitro translation 11053425
CARD Bcl-10 Link CARD9 Two-hybrid Not specified 1-104 HEK293 Human 1-110 HEK293 11053425
CARD Bcl-10 Link RAIDD Two-hybrid Not specified Not specified HEK293 Not specified Not specified HEK293 22323537
CARD BinCARD Link Bcl-10 GST fusion protein pull-down Human Not specified In vitro translation Not specified Not specified E.coli 15637807
CARD CARD10 Link Bcl-10 GST fusion protein pull-down Human Not specified In vitro translation Not specified Not specified E.coli 11259443
CARD CARD10 Link Bcl-10 Two-hybrid Human 1-138 HEK293 Not specified 1-104 HEK293 11259443
CARD CARD11 Link Bcl-10 GST fusion protein pull-down Not specified 1-126 In vitro translation Not specified Not specified E.coli 11278692
CARD CARD11 Link Bcl-10 In vitro purification protein assembly(chemical crosslinking) Mouse 1-160 E.coli Mouse Not specified E.coli 20439115
CARD CARD11 Link Bcl-10 Two-hybrid Not specified 1-126 HEK293 Not specified Not specified HEK293 11278692
CARD CARD12 Link ASC GST fusion protein pull-down Human 1-88 E.coli Human 105-195 In vitro translation 11967258
CARD CARD12 Link ASC GST fusion protein pull-down Human 1-88 E.coli Human Full length In vitro translation 11967258
CARD CARD12 Link ASC Two-hybrid Not specified 1-83 HEK293 Not specified Not specified HEK293 11374873
CARD CARD12 Link ASC Yeast two-hybrid Human 1-96 Yeast Human Full length Yeast 19337385
CARD CARD12 Link CARD12 GST fusion protein pull-down Not specified Full length Not specified Not specified 1-88 Not specified 11390368
CARD CARD12 Link CARD12 Two-hybrid Not specified 1-83 HEK293 Not specified 1-83 HEK293 11374873
CARD CARD12 Link Caspase1 GST fusion protein pull-down Not specified 1-88 Not specified Not specified Full length Not specified 11390368
CARD CARD14 Link Bcl-10 GST fusion protein pull-down Not specified 1-118 In vitro translation Not specified Not specified E.coli 11278692
CARD CARD14 Link Bcl-10 Two-hybrid Not specified 1-118 HEK293 Not specified Not specified HEK293 11278692
CARD CARD16 Link ASC GST fusion protein pull-down Human Full length E.coli Human 105-195 In vitro translation 11967258
CARD CARD16 Link ASC GST fusion protein pull-down Human Full length E.coli Human Full length In vitro translation 11967258
CARD CARD16 Link CARD18 GST fusion protein pull-down Human 1-106 E.coli Human Full length In vitro translation 11536016
CARD CARD16 Link CARD8 GST fusion protein pull-down Not specified Not specified In vitro translation Not specified Full length E.coli 11821383
CARD CARD16 Link Caspase1 GST fusion protein pull-down Human 1-106 E.coli Not specified Not specified In vitro translation 11536016
CARD CARD16 Link Caspase1 GST fusion protein pull-down Not specified Not specified E.coli Not specified Not specified In vitro translation 11821383
CARD CARD18 Link CARD16 GST fusion protein pull-down Human Full length In vitro translation Human 1-106 E.coli 11536016
CARD CARD18 Link CARD8 GST fusion protein pull-down Not specified Not specified In vitro translation Not specified Full length E.coli 11821383
CARD CARD18 Link Caspase1 GST fusion protein pull-down Human Full length E.coli Not specified Not specified In vitro translation 11536016
CARD CARD18 Link Caspase1 In vitro purification protein assembly(immunoprecipitation) Not specified Full length E.coli Not specified 1-92 E.coli 11051551
CARD CARD8 Link CARD16 GST fusion protein pull-down Not specified Full length E.coli Not specified Not specified In vitro translation 11821383
CARD CARD8 Link CARD18 GST fusion protein pull-down Not specified Full length E.coli Not specified Not specified In vitro translation 11821383
CARD CARD8 Link CARD8 Yeast two-hybrid Human 342-430 Yeast Human 342-430 Yeast 19337385
CARD CARD8 Link Caspase1 GST fusion protein pull-down Not specified Full length E.coli Not specified Not specified In vitro translation 11821383
CARD CARD8 Link Caspase1 Yeast two-hybrid Human 342-430 Yeast Human 1-91 Yeast 19337385
CARD CARD8 Link Caspase9 GST fusion protein pull-down Human Full length In vitro translation Not specified Not specified E.coli 11408476
CARD CARD9 Link Bcl-10 GST fusion protein pull-down Human Full length In vitro translation Herpesvirus2 Not specified E.coli 11053425
CARD CARD9 Link Bcl-10 Two-hybrid Human 1-110 HEK293 Not specified 1-104 HEK293 11053425
CARD Caspase1 Link ASC GST fusion protein pull-down Not specified Not specified E.coli Human 105-195 In vitro translation 11967258
CARD Caspase1 Link ASC GST fusion protein pull-down Not specified Not specified E.coli Human Full length In vitro translation 11967258
CARD Caspase1 Link ASC GST fusion protein pull-down Not specified Not specified In vitro translation Not specified Not specified E.coli 14634131
CARD Caspase1 Link ASC Yeast two-hybrid Human 1-91 Yeast Human 105-195 Yeast 19337385
CARD Caspase1 Link CARD12 GST fusion protein pull-down Not specified Full length Not specified Not specified 1-88 Not specified 11390368
CARD Caspase1 Link CARD16 GST fusion protein pull-down Not specified Not specified In vitro translation Human 1-106 E.coli 11536016
CARD Caspase1 Link CARD16 GST fusion protein pull-down Not specified Not specified In vitro translation Not specified Not specified E.coli 11821383
CARD Caspase1 Link CARD18 GST fusion protein pull-down Not specified Not specified In vitro translation Human Full length E.coli 11536016
CARD Caspase1 Link CARD18 In vitro purification protein assembly(immunoprecipitation) Not specified 1-92 E.coli Not specified Full length E.coli 11051551
CARD Caspase1 Link CARD8 GST fusion protein pull-down Not specified Not specified In vitro translation Not specified Full length E.coli 11821383
CARD Caspase1 Link CARD8 Yeast two-hybrid Human 1-91 Yeast Human 342-430 Yeast 19337385
CARD Caspase1 Link RIPK2 GST fusion protein pull-down Not specified 1-92 In vitro translation Not specified 454-540 E.coli 11051551
CARD Caspase2 Link Caspase2 Yeast two-hybrid Human 32-121 Yeast Human 32-121 Yeast 19337385
CARD Caspase2 Link RAIDD GST fusion protein pull-down Not specified Not specified In vitro translation Human Not specified E.coli 9044836
CARD Caspase2 Link RAIDD His fusion protein pull-down Human Full length In vitro translation Not specified Not specified E.coli 8985253
CARD Caspase2 Link RAIDD His fusion protein pull-down Human Full length In vitro translation Not specified 1-117 E.coli 8985253
CARD Caspase2 Link RAIDD His fusion protein pull-down Human 1-140 In vitro translation Not specified Not specified E.coli 8985253
CARD Caspase2 Link RAIDD In vitro purification protein assembly(Native gel-electrophoresis) Human 31-121 E.coli Human Full length E.coli 20872280
CARD Caspase2 Link RAIDD In vitro purification protein assembly(Size-exclusion chromatography) Not specified 1-104 HEK293 Not specified Full length HEK293 15073321
CARD Caspase2 Link RAIDD In vitro purification protein assembly(Size-exclusion chromatography) Human 31-121 E.coli Human Full length E.coli 20872280
CARD Caspase2 Link RAIDD Yeast two-hybrid Human Not specified Yeast Not specified Not specified Yeast 11156409
CARD Caspase9 Link Apaf1 GST fusion protein pull-down Not specified Not specified In vitro translation Not specified 1-97 E.coli 9390557
CARD Caspase9 Link Apaf1 GST fusion protein pull-down Not specified Not specified In vitro translation Not specified 1-97 E.coli 9922454
CARD Caspase9 Link Apaf1 GST fusion protein pull-down Not specified Not specified E.coli Not specified 1-420 In vitro translation 11408476
CARD Caspase9 Link Apaf1 GST fusion protein pull-down Not specified Not specified In vitro translation Not specified Not specified E.coli 11821383
CARD Caspase9 Link Apaf1 GST fusion protein pull-down Not specified 1-130 E.coli Human THP-1 lysate 14993223
CARD Caspase9 Link Apaf1 GST fusion protein pull-down Not specified D32cell lysate Not specified Not specified E.coli 15542838
CARD Caspase9 Link Apaf1 GST fusion protein pull-down Not specified Not specified E.coli Not specified D32cell lysate 15542838
CARD Caspase9 Link Apaf1 In vitro purification protein assembly(Size-exclusion chromatography) Not specified Full length HeLa Human Full length HeLa 10206961
CARD Caspase9 Link Apaf1 In vitro purification protein assembly(Size-exclusion chromatography) Human 1-112 E.coli Human 1-97 E.coli 10376594
CARD Caspase9 Link Apaf1 In vitro purification protein assembly(Size-exclusion chromatography) Not specified THP-1 lysate Not specified THP-1 lysate 11230124
CARD Caspase9 Link Apaf1 In vitro purification protein assembly(Size-exclusion chromatography) Not specified Full length E.coli Not specified 1-97 E.coli 11904389
CARD Caspase9 Link Apaf1 In vitro purification protein assembly(Size-exclusion chromatography) Not specified 1-132 E.coli Not specified 1-97 E.coli 11904389
CARD Caspase9 Link Apaf1 In vitro purification protein assembly(Size-exclusion chromatography) Not specified Not specified E.coli Not specified Not specified E.coli 19494828
CARD Caspase9 Link Apaf1 Yeast two-hybrid Human 1-97 Yeast Human 1-92 Yeast 19337385
CARD Caspase9 Link CARD8 GST fusion protein pull-down Not specified Not specified E.coli Human Full length In vitro translation 11408476
CARD Caspase9 Link Caspase9 In vitro purification protein assembly(2D gel electrophoresis) U937 lysate U937 lysate 14747474
CARD Caspase9 Link CIAP1 GST fusion protein pull-down Not specified Not specified In vitro translation Not specified Not specified U937 9545235
CARD Caspase9 Link CIAP2 GST fusion protein pull-down Not specified Not specified In vitro translation Not specified Not specified U937 9545235
CARD CIAP1 Link Caspase9 GST fusion protein pull-down Not specified Not specified U937 Not specified Not specified In vitro translation 9545235
CARD CIAP1 Link RIPK2 GST fusion protein pull-down Not specified Not specified E.coli Not specified Full length In vitro translation 19464198
CARD CIAP1 Link RIPK2 GST fusion protein pull-down Not specified Not specified E.coli Human Not specified In vitro translation 21931591
CARD CIAP2 Link Caspase9 GST fusion protein pull-down Not specified Not specified U937 Not specified Not specified In vitro translation 9545235
CARD CIAP2 Link RIPK2 GST fusion protein pull-down Not specified Not specified E.coli Not specified Full length In vitro translation 19464198
CARD CIAP2 Link RIPK2 GST fusion protein pull-down Not specified Not specified E.coli Human Not specified In vitro translation 21931591
CARD NLRP1 Link Apaf1 GST fusion protein pull-down Not specified Not specified E.coli Not specified Not specified In vitro translation 11113115
CARD NOD1 Link RIPK2 GST fusion protein pull-down Not specified 17-138 E.coli Not specified 435-528 E.coli 22470564
CARD NOD1 Link RIPK2 Yeast two-hybrid Human 1-145 Yeast Not specified Full length Yeast 10224040
CARD NOD1 Link RIPK2 Yeast two-hybrid Human 1-145 Yeast Not specified 384-540 Yeast 10224040
CARD NOD1 Link RIPK2 Yeast two-hybrid Human 1-110 Yeast Human 427-527 Yeast 19337385
CARD NOD1 Link RIPK2 Yeast two-hybrid Human 16-108 Yeast Human 427-527 Yeast 19337385
CARD NOD2 Link NOD2 In vitro purification protein assembly(Isothermal titration calorimety) Not specified 28-119 E.coli Not specified 120-218 E.coli 22470564
CARD NOD2 Link NOD2 Yeast two-hybrid Human 1-267 Yeast Human 1-267 Yeast 19337385
CARD NOD2 Link RIG-1 His Fusion protein pull-down Not specified 1-301 E.coli Not specified 1-205 E.coli 21690088
CARD NOD2 Link RIPK2 GST fusion protein pull-down Not specified 28-218 E.coli Not specified 435-528 E.coli 22470564
CARD NOD2 Link RIPK2 Yeast two-hybrid Human 1-267 Yeast Human 427-527 Yeast 19337385
CARD RAIDD Link Bcl-10 Two-hybrid Not specified Not specified HEK293 Not specified Not specified HEK293 22323537
CARD RAIDD Link Caspase2 GST fusion protein pull-down Human Not specified E.coli Not specified Not specified In vitro translation 9044836
CARD RAIDD Link Caspase2 His fusion protein pull-down Not specified Not specified E.coli Human Full length In vitro translation 8985253
CARD RAIDD Link Caspase2 His fusion protein pull-down Not specified 1-117 E.coli Human Full length In vitro translation 8985253
CARD RAIDD Link Caspase2 His fusion protein pull-down Not specified Not specified E.coli Human 1-140 In vitro translation 8985253
CARD RAIDD Link Caspase2 In vitro purification protein assembly(Native gel-electrophoresis) Human Full length E.coli Human 31-121 E.coli 20872280
CARD RAIDD Link Caspase2 In vitro purification protein assembly(Size-exclusion chromatography) Not specified Full length HEK293 Not specified 1-104 HEK293 15073321
CARD RAIDD Link Caspase2 In vitro purification protein assembly(Size-exclusion chromatography) Human Full length E.coli Human 31-121 E.coli 20872280
CARD RAIDD Link Caspase2 Yeast two-hybrid Not specified Not specified Yeast Human Not specified Yeast 11156409
CARD RIG-1 Link NOD2 His Fusion protein pull-down Not specified 1-205 E.coli Not specified 1-301 E.coli 21690088
CARD RIPK2 Link Caspase1 GST fusion protein pull-down Not specified 454-540 E.coli Not specified 1-92 In vitro translation 11051551
CARD RIPK2 Link CIAP1 GST fusion protein pull-down Not specified Full length In vitro translation Not specified Not specified E.coli 19464198
CARD RIPK2 Link CIAP1 GST fusion protein pull-down Human Not specified In vitro translation Not specified Not specified E.coli 21931591
CARD RIPK2 Link CIAP2 GST fusion protein pull-down Not specified Full length In vitro translation Not specified Not specified E.coli 19464198
CARD RIPK2 Link CIAP2 GST fusion protein pull-down Human Not specified In vitro translation Not specified Not specified E.coli 21931591
CARD RIPK2 Link NOD1 GST fusion protein pull-down Not specified 435-528 E.coli Not specified 17-138 E.coli 22470564
CARD RIPK2 Link NOD1 Yeast two-hybrid Not specified Full length Yeast Human 1-145 Yeast 10224040
CARD RIPK2 Link NOD1 Yeast two-hybrid Not specified 384-540 Yeast Human 1-145 Yeast 10224040
CARD RIPK2 Link NOD1 Yeast two-hybrid Human 427-527 Yeast Human 1-110 Yeast 19337385
CARD RIPK2 Link NOD1 Yeast two-hybrid Human 427-527 Yeast Human 16-108 Yeast 19337385
CARD RIPK2 Link NOD2 GST fusion protein pull-down Not specified 435-528 E.coli Not specified 28-218 E.coli 22470564
CARD RIPK2 Link NOD2 Yeast two-hybrid Human 427-527 Yeast Human 1-267 Yeast 19337385
CARD RIPK2 Link RIPK2 Yeast two-hybrid Human 427-527 Yeast Human 427-527 Yeast 19337385
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression		 Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
CARD Apaf1 Link Apaf1 Co-immunoprecipitation HEK293 Not specified Full length Not specified 1-559 9837928
CARD Apaf1 Link Apaf1 Co-immunoprecipitation HEK293 Not specified 1-559 Not specified 1-559 9837928
CARD Apaf1 Link Apaf1 Co-immunoprecipitation HEK293 Not specified 1-559 Not specified 1-455 9837928
CARD Apaf1 Link Apaf1 Co-immunoprecipitation HEK293 Human Not specified Human Not specified 10944114
CARD Apaf1 Link Caspase2 Size-exclusion chromatography HeLa 12460989
CARD Apaf1 Link Caspase4 Co-immunoprecipitation HEK293 Not specified Full length Human Not specified 9539746
CARD Apaf1 Link Caspase9 Co-immunoprecipitation HeLa S-100 9390557
CARD Apaf1 Link Caspase9 Co-immunoprecipitation HEK293 Not specified Full length Not specified Full length 9488720
CARD Apaf1 Link Caspase9 Co-immunoprecipitation HEK293 Not specified 1-412 Not specified Full length 9488720
CARD Apaf1 Link Caspase9 Co-immunoprecipitation HEK293 Not specified 1-412 Not specified 1-168 9488720
CARD Apaf1 Link Caspase9 Co-immunoprecipitation HEK293 Not specified Full length Human Not specified 9539746
CARD Apaf1 Link Caspase9 Co-immunoprecipitation HEK293 Not specified 1-559 Human Not specified 9539746
CARD Apaf1 Link Caspase9 Co-immunoprecipitation Rat cardiomyocyte 15253891
CARD Apaf1 Link Caspase9 Size-exclusion chromatography HEK293 10617566
CARD Apaf1 Link Caspase9 Size-exclusion chromatography Human monocytic tumor cell 10692394
CARD Apaf1 Link Caspase9 Size-exclusion chromatography THP-1 11550094
CARD Apaf1 Link Caspase9 Size-exclusion chromatography HeLa 12460989
CARD Apaf1 Link Caspase9 Size-exclusion chromatography Rat cortex 14602082
CARD Apaf1 Link NLRP1 Co-immunoprecipitation HEK293 Not specified Full length Not specified Full length 11113115
CARD Apaf1 Link NLRP1 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 17418785
CARD ASC Link ASC Co-immunoprecipitation COS-7 Not specified 1-100 Not specified 1-100 11162571
CARD ASC Link CARD12 Co-immunoprecipitation HEK293 Not specified Full length Not specified 1-647 12646168
CARD ASC Link CARD12 Co-immunoprecipitation HEK293 Human Not specified Human 1-457 15701651
CARD ASC Link Caspase1 Co-immunoprecipitation HEK293 Human 105-195 Not specified Not specified 11967258
CARD ASC Link Caspase1 Co-immunoprecipitation HEK293 Human Full length Not specified Not specified 11967258
CARD ASC Link Caspase1 Co-immunoprecipitation HEK293 Not specified 92-195 Not specified Not specified 12019269
CARD ASC Link caspase1 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 12191486
CARD ASC Link Caspase1 Co-immunoprecipitation PT67 Mouse Full length Mouse Not specified 12667444
CARD ASC Link Caspase1 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 14634131
CARD ASC Link Caspase1 Co-immunoprecipitation THP-1 14634131
CARD ASC Link Caspase1 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 16585594
CARD ASC Link Caspase1 Co-immunoprecipitation THP-1 16585594
CARD ASC Link Caspase1 Co-immunoprecipitation Rat cortical lysate 19401709
CARD ASC Link Caspase1 Co-immunoprecipitation HEK239 Human Not specified Human Not specified 21862576
CARD ASC Link Caspase1 GST fusion protein pull-down PT67 Mouse Full length Mouse Not specified 12667444
CARD ASC Link Caspase1 Size-exclusion chromatography Mice cerebral cortex 19066616
CARD ASC Link RIPK2 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 14634131
CARD Bcl-10 Link Bcl-10 Co-immunoprecipitation HEK293 Human Full length Human Full length 10364242
CARD Bcl-10 Link Bcl-10 Co-immunoprecipitation HEK293 Human Full length Human 1-104 10364242
CARD Bcl-10 Link Bcl-10 Co-immunoprecipitation HEK293 Not specified Full length Human Full length 14638696
CARD Bcl-10 Link Bcl-10 Co-immunoprecipitation HEK293 Not specified 1-127 Not specified 1-127 19538180
CARD Bcl-10 Link Bcl-10 GST fusion protein pull-down HEK293 Human Full length Human Full length 10187815
CARD Bcl-10 Link BinCARD Co-Immunofluorescence staining HeLa Not specified Not specified Human Not specified 15637807
CARD Bcl-10 Link BinCARD Co-immunoprecipitation HEK293 Not specified Not specified Human Not specified 15637807
CARD Bcl-10 Link CARD10 Co-immunoprecipitation HEK293 Not specified Not specified Human Not specified 11259443
CARD Bcl-10 Link CARD10 Co-immunoprecipitation HEK293 Not used Human Not specified 11259443
CARD Bcl-10 Link CARD10 Co-immunoprecipitation HEK293 Not specified Not specified Human 1-116 11387339
CARD Bcl-10 Link CARD10 Co-immunoprecipitation HEK293 Not specified 1-127 Not specified Not specified 19538180
CARD Bcl-10 Link CARD11 Co-Immunofluorescence staining HeLa Human 2-233 Human 1-153 11356195
CARD Bcl-10 Link CARD11 Co-immunoprecipitation HEK293 Not used Not specified 1-126 11278692
CARD Bcl-10 Link CARD11 Co-immunoprecipitation HEK293 Human 2-233 Human 1-153 11356195
CARD Bcl-10 Link CARD11 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 12154360
CARD Bcl-10 Link CARD11 Co-immunoprecipitation HEK293 Mouse Not specified Human 1-470 16809782
CARD Bcl-10 Link CARD11 Co-immunoprecipitation Jurkat 16818229
CARD Bcl-10 Link CARD11 Co-immunoprecipitation DO11.10 17478723
CARD Bcl-10 Link CARD11 Co-immunoprecipitation DT40 Not used Not specified Not specified 18086859
CARD Bcl-10 Link CARD11 Co-immunoprecipitation DO11.10 18802088
CARD Bcl-10 Link CARD11 Co-immunoprecipitation Jurkat 19444310
CARD Bcl-10 Link CARD11 Co-immunoprecipitation DLBCL 19841089
CARD Bcl-10 Link CARD11 Co-immunoprecipitation Jurkat 21157432
CARD Bcl-10 Link CARD11 Co-immunoprecipitation Jurkat 21199863
CARD Bcl-10 Link CARD12 Co-immunoprecipitation HEK293 Not specified Not specified Human Not specified 11472070
CARD Bcl-10 Link CARD14 Co-immunoprecipitation HEK293 Not used Not specified 1-118 11278692
CARD Bcl-10 Link CARD9 Co-Immunofluorescence staining Rat-1 cell Herpesvirus2 Full length Human Full length 11053425
CARD Bcl-10 Link CARD9 Co-immunoprecipitation HEK293 Herpesvirus2 Not specified Human Full length 11053425
CARD Bcl-10 Link CARD9 Co-immunoprecipitation HEK293 11053425
CARD Bcl-10 Link CARD9 Co-immunoprecipitation Bone marrow derived macrophage 20538615
CARD Bcl-10 Link CARD9 Co-immunoprecipitation THP-1 20538615
CARD Bcl-10 Link CARMA1 Co-immunoprecipitation HEK293 Mouse 1-121 Mouse 1-155 22880103
CARD Bcl-10 Link CIAP2 Co-immunoprecipitation Rat brain hippocampus 12786973
CARD Bcl-10 Link CIAP2 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 16775419
CARD Bcl-10 Link RAIDD Co-immunoprecipitation HEK293 Not specified Not specified Not used 22323537
CARD Bcl-10 Link RIPK2 Co-immunoprecipitation HEK293 Human Full length Not specified Full length 14638696
CARD Bcl-10 Link RIPK2 Co-immunoprecipitation HEK293 Not specified Full length Human Full length 14638696
CARD BinCARD Link Bcl-10 Co-Immunofluorescence staining HeLa Human Not specified Not specified Not specified 15637807
CARD BinCARD Link Bcl-10 Co-immunoprecipitation HEK293 Human Not specified Not specified Not specified 15637807
CARD CARD10 Link Bcl-10 Co-immunoprecipitation HEK293 Human Not specified Not specified Not specified 11259443
CARD CARD10 Link Bcl-10 Co-immunoprecipitation HEK293 Human Not specified Not used 11259443
CARD CARD10 Link Bcl-10 Co-immunoprecipitation HEK293 Human 1-116 Not specified Not specified 11387339
CARD CARD10 Link Bcl-10 Co-immunoprecipitation HEK293 Not specified Not specified Not specified 1-127 19538180
CARD CARD11 Link Bcl-10 Co-Immunofluorescence staining HeLa Human 1-153 Human 2-233 11356195
CARD CARD11 Link Bcl-10 Co-immunoprecipitation HEK293 Not specified 1-126 Not used 11278692
CARD CARD11 Link Bcl-10 Co-immunoprecipitation HEK293 Human 1-153 Human 2-233 11356195
CARD CARD11 Link Bcl-10 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 12154360
CARD CARD11 Link Bcl-10 Co-immunoprecipitation HEK293 Human 1-470 Mouse Not specified 16809782
CARD CARD11 Link Bcl-10 Co-immunoprecipitation Jurkat 16818229
CARD CARD11 Link Bcl-10 Co-immunoprecipitation DO11.10 17478723
CARD CARD11 Link Bcl-10 Co-immunoprecipitation DT40 Not specified Not specified Not used 18086859
CARD CARD11 Link Bcl-10 Co-immunoprecipitation DO11.10 18802088
CARD CARD11 Link Bcl-10 Co-immunoprecipitation Jurkat 19444310
CARD CARD11 Link Bcl-10 Co-immunoprecipitation DLBCL 19841089
CARD CARD11 Link Bcl-10 Co-immunoprecipitation Jurkat 21157432
CARD CARD11 Link Bcl-10 Co-immunoprecipitation Jurkat 21199863
CARD CARD11 Link CARD11 Co-immunoprecipitation HEK293 Murine 2-1159 Murine 2-1159 18625728
CARD CARD12 Link ASC Co-immunoprecipitation HEK293 Not specified 1-647 Not specified Full length 12646168
CARD CARD12 Link ASC Co-immunoprecipitation HEK293 Human 1-457 Human Not specified 15701651
CARD CARD12 Link Bcl-10 Co-immunoprecipitation HEK293 Human Not specified Not specified Not specified 11472070
CARD CARD12 Link CARD12 Co-immunoprecipitation HEK293 Not specified Full length Not specified Full length 11390368
CARD CARD12 Link CARD12 Co-immunoprecipitation HEK293 Not specified Full length Not specified 1-88 11390368
CARD CARD12 Link CARD12 Co-immunoprecipitation HEK293 Human Not specified Human Not specified 11472070
CARD CARD12 Link Caspase1 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 11374873
CARD CARD12 Link Caspase1 Co-immunoprecipitation HEK293 Not specified Full length Human Full length 11390368
CARD CARD12 Link Caspase1 Co-immunoprecipitation HEK293 Not specified 1-88 Human 1-94 11390368
CARD CARD12 Link Caspase1 Co-immunoprecipitation HEK293 Human Not specified Not specified Not specified 11472070
CARD CARD12 Link Caspase1 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 17418785
CARD CARD12 Link NLRP1 Co-immunoprecipitation HEK293 Human Not specified Not specified Not specified 11472070
CARD CARD12 Link NOD2 Co-immunoprecipitation HEK293 Human Not specified Not specified Not specified 11472070
CARD CARD14 Link Bcl-10 Co-immunoprecipitation HEK293 Not specified 1-118 Not used 11278692
CARD CARD16 Link CARD16 Co-immunoprecipitation HEK293 Human Not specified Human Not specified 11432859
CARD CARD16 Link CARD17 Co-immunoprecipitation HEK293 Human 1-106 Human Not specified 15383541
CARD CARD16 Link CARD18 Co-immunoprecipitation HEK293 Human 1-106 Human Full length 11536016
CARD CARD16 Link CARD8 Co-immunoprecipitation HEK293 Not specified Full length Not specified Not specified 11821383
CARD CARD16 Link CARD8 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Full length 11821383
CARD CARD16 Link Caspase1 Co-immunoprecipitation HEK293 Human Not specified Not specified Full length 11432859
CARD CARD16 Link Caspase1 Co-immunoprecipitation HEK293 Human Not specified Not specified 1-120 11432859
CARD CARD16 Link Caspase1 Co-immunoprecipitation HEK293 Human 1-106 Not specified Not specified 11536016
CARD CARD16 Link RIPK2 Co-immunoprecipitation HEK293 Human Not specified Not specified Full length 11432859
CARD CARD16 Link RIPK2 Co-immunoprecipitation HEK293 Human 1-106 Not specified Not specified 11536016
CARD CARD17 Link CARD16 Co-immunoprecipitation HEK293 Human Not specified Human 1-106 15383541
CARD CARD17 Link CARD17 Co-immunoprecipitation HEK293 Human Not specified Human Not specified 15383541
CARD CARD17 Link CARD18 Co-immunoprecipitation HEK293 Human Not specified Human Full length 15383541
CARD CARD17 Link Caspase1 Co-immunoprecipitation HEK293 Human Not specified Not specified Not specified 15383541
CARD CARD18 Link CARD16 Co-immunoprecipitation HEK293 Human Full length Human 1-106 11536016
CARD CARD18 Link CARD17 Co-immunoprecipitation HEK293 Human Full length Human Not specified 15383541
CARD CARD18 Link Caspase1 Co-immunoprecipitation HEK293 Human Full length Not specified Not specified 11536016
CARD CARD18 Link RIPK2 Co-immunoprecipitation HEK293 Human Full length Not specified Not specified 11536016
CARD CARD6 Link CARD8 Co-immunoprecipitation HEK293 Human 1-311 Human Full length 12775719
CARD CARD6 Link NLRP1 Co-immunoprecipitation HEK293 Human 1-311 Not specified Full length 12775719
CARD CARD6 Link NOD1 Co-immunoprecipitation HEK293 Human 1-311 Not specified Not specified 12775719
CARD CARD6 Link RIPK2 Co-immunoprecipitation HEK293 Human 1-311 Not specified Not specified 12775719
CARD CARD8 Link CARD16 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Full length 11821383
CARD CARD8 Link CARD16 Co-immunoprecipitation HEK293 Not specified Full length Not specified Not specified 11821383
CARD CARD8 Link CARD6 Co-immunoprecipitation HEK293 Human Full length Human 1-311 12775719
CARD CARD8 Link CARD8 Co-immunoprecipitation HEK293 Human Full length Human Full length 11408476
CARD CARD8 Link Caspase1 Co-immunoprecipitation HEK293 Not specified Full length Not specified Not specified 11821383
CARD CARD8 Link Caspase1 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Full length 11821383
CARD CARD8 Link Caspase1 Co-immunoprecipitation HEK293 Not specified 320-431 Not specified Not specified 15030775
CARD CARD8 Link Caspase9 Co-immunoprecipitation HEK293 Human Full length Not specified Not specified 11408476
CARD CARD9 Link Bcl-10 Co-Immunofluorescence staining Rat-1 cell Human Full length Herpesvirus2 Full length 11053425
CARD CARD9 Link Bcl-10 Co-immunoprecipitation HEK293 Human Full length Herpesvirus2 Not specified 11053425
CARD CARD9 Link Bcl-10 Co-immunoprecipitation HEK293 11053425
CARD CARD9 Link Bcl-10 Co-immunoprecipitation Bone marrow derived macrophage 20538615
CARD CARD9 Link Bcl-10 Co-immunoprecipitation THP-1 20538615
CARD CARD9 Link CARD9 Co-immunoprecipitation HEK293 Human Full length Human Full length 11053425
CARD CARD9 Link RIPK2 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 17486093
CARD CARMA1 Link Bcl-10 Co-immunoprecipitation HEK293 Mouse 1-155 Mouse 1-121 22880103
CARD Caspase1 Link ASC Co-immunoprecipitation HEK293 Not specified Not specified Human 105-195 11967258
CARD Caspase1 Link ASC Co-immunoprecipitation HEK293 Not specified Not specified Human Full length 11967258
CARD Caspase1 Link ASC Co-immunoprecipitation HEK293 Not specified Not specified Not specified 92-195 12019269
CARD caspase1 Link ASC Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 12191486
CARD Caspase1 Link ASC Co-immunoprecipitation PT67 Mouse Not specified Mouse Full length 12667444
CARD Caspase1 Link ASC Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 14634131
CARD Caspase1 Link ASC Co-immunoprecipitation THP-1 14634131
CARD Caspase1 Link ASC Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 16585594
CARD Caspase1 Link ASC Co-immunoprecipitation THP-1 16585594
CARD Caspase1 Link ASC Co-immunoprecipitation Rat cortical lysate 19401709
CARD Caspase1 Link ASC Co-immunoprecipitation HEK239 Human Not specified Human Not specified 21862576
CARD Caspase1 Link ASC GST fusion protein pull-down PT67 Mouse Not specified Mouse Full length 12667444
CARD Caspase1 Link ASC Size-exclusion chromatography Mice cerebral cortex 19066616
CARD Caspase1 Link CARD12 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 11374873
CARD Caspase1 Link CARD12 Co-immunoprecipitation HEK293 Human Full length Not specified Full length 11390368
CARD Caspase1 Link CARD12 Co-immunoprecipitation HEK293 Human 1-94 Not specified 1-88 11390368
CARD Caspase1 Link CARD12 Co-immunoprecipitation HEK293 Not specified Not specified Human Not specified 11472070
CARD Caspase1 Link CARD12 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 17418785
CARD Caspase1 Link CARD16 Co-immunoprecipitation HEK293 Not specified Full length Human Not specified 11432859
CARD Caspase1 Link CARD16 Co-immunoprecipitation HEK293 Not specified 1-120 Human Not specified 11432859
CARD Caspase1 Link CARD16 Co-immunoprecipitation HEK293 Not specified Not specified Human 1-106 11536016
CARD Caspase1 Link CARD17 Co-immunoprecipitation HEK293 Not specified Not specified Human Not specified 15383541
CARD Caspase1 Link CARD18 Co-immunoprecipitation HEK293 Not specified Not specified Human Full length 11536016
CARD Caspase1 Link CARD8 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Full length 11821383
CARD Caspase1 Link CARD8 Co-immunoprecipitation HEK293 Not specified Full length Not specified Not specified 11821383
CARD Caspase1 Link CARD8 Co-immunoprecipitation HEK293 Not specified Not specified Not specified 320-431 15030775
CARD Caspase1 Link Caspase1 Co-immunoprecipitation HEK293 Not specified Full length Not specified Full length 11432859
CARD Caspase1 Link Caspase1 Co-immunoprecipitation HEK239 Human Not specified Human Not specified 21862576
CARD Caspase1 Link Caspase12 Co-immunoprecipitation HEK293 Not specified Not specified Rodent Not specified 16625199
CARD Caspase1 Link Caspase12 Co-immunoprecipitation HEK293 Not specified Not specified Rat Full length 18332441
CARD Caspase1 Link NLRP1 Co-immunoprecipitation HEK293 Human Not specified Human Full length 17349957
CARD Caspase1 Link NLRP1 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 17418785
CARD Caspase1 Link NLRP1 Co-immunoprecipitation Rat cortical lysate 19401709
CARD Caspase1 Link NLRP1 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 21252346
CARD Caspase1 Link NLRP1 Size-exclusion chromatography Mice cerebral cortex 19066616
CARD Caspase1 Link NOD1 Co-immunoprecipitation HEK293 Not specified Not specified Human Full length 10329646
CARD Caspase1 Link NOD1 Co-immunoprecipitation HEK293 Not specified 1-102 Not specified 1-158 12459189
CARD Caspase1 Link NOD2 Co-immunoprecipitation HEK293 Not specified Full length Not specified Full length 18511561
CARD Caspase1 Link RIPK2 Co-immunoprecipitation HEK293 Human 2-540 Human 2-92 9705938
CARD Caspase1 Link RIPK2 Co-immunoprecipitation HEK293 Not specified Full length Not specified Not specified 11051551
CARD Caspase1 Link RIPK2 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 11536016
CARD Caspase1 Link RIPK2 Co-immunoprecipitation HEK293 Human 2-540 Murine Not specified 15039421
CARD Caspase1 Link RIPK2 Co-immunoprecipitation HEK293 Human 431-540 Murine Not specified 15039421
CARD Caspase1 Link RIPK2 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 16585594
CARD Caspase1 Link RIPK2 Co-immunoprecipitation THP-1 16585594
CARD Caspase1 Link RIPK2 Co-immunoprecipitation HEK239 Human Not specified Not specified Not specified 21862576
CARD Caspase12 Link Caspase1 Co-immunoprecipitation HEK293 Rodent Not specified Not specified Not specified 16625199
CARD Caspase12 Link Caspase1 Co-immunoprecipitation HEK293 Rat Full length Not specified Not specified 18332441
CARD Caspase12 Link Caspase12 Co-immunoprecipitation HEK293 Mouse Full length Mouse Full length 11278723
CARD Caspase12 Link RIG-1 Co-Immunofluorescence staining Mouse embryonic fibroblast Not specified Not specified Human Not specified 20818395
CARD Caspase12 Link RIG-1 GST fusion protein pull-down Mouse embryonic fibroblast Not specified Not specified Human Not specified 20818395
CARD Caspase2 Link Apaf1 Size-exclusion chromatography HeLa 12460989
CARD Caspase2 Link Caspase2 Bimolecular fluorescence complementation HeLa Not specified 1-122 Not specified 1-122 19782032
CARD Caspase2 Link NLRP1 Co-immunoprecipitation HEK293 Not specified Not specified Human Full length 11076957
CARD Caspase2 Link NLRP1 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 12191486
CARD Caspase2 Link NOD1 Co-immunoprecipitation HEK293 Not specified Not specified Human Full length 10329646
CARD Caspase2 Link NOL3 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 9560245
CARD Caspase2 Link RAIDD Co-Immunofluorescence staining HEK293 Mouse Full length Human Full length 10713730
CARD Caspase2 Link RAIDD Co-immunoprecipitation HEK293 Human Full length Not specified Not specified 8985253
CARD Caspase2 Link RAIDD Co-immunoprecipitation HEK293 Mouse Full length Human Full length 10713730
CARD Caspase2 Link RAIDD Co-immunoprecipitation Namalwa Human Not specified Not specified Not specified 11156409
CARD Caspase2 Link RAIDD Co-immunoprecipitation Mouse brain cell 11978827
CARD Caspase2 Link RAIDD Co-immunoprecipitation HEK293 Not specified 1-104 Not specified Full length 15073321
CARD Caspase2 Link RAIDD Co-immunoprecipitation HCL116 16652156
CARD Caspase2 Link RAIDD Co-immunoprecipitation Hippocampal CA1 subregion 18845684
CARD Caspase2 Link RAIDD Co-immunoprecipitation HEK293 Not specified 1-122 Not specified Not specified 19782032
CARD Caspase2 Link RAIDD Co-immunoprecipitation rat hippocampal neuron 22515271
CARD Caspase4 Link Apaf1 Co-immunoprecipitation HEK293 Human Not specified Not specified Full length 9539746
CARD Caspase4 Link NLRP1 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 12191486
CARD Caspase4 Link NOD1 Co-immunoprecipitation HEK293 Not specified Not specified Human Full length 10329646
CARD Caspase5 Link NLRP1 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 12191486
CARD Caspase5 Link NLRP1 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 17418785
CARD Caspase9 Link Apaf1 Co-immunoprecipitation HeLa S-100 9390557
CARD Caspase9 Link Apaf1 Co-immunoprecipitation HEK293 Not specified Full length Not specified Full length 9488720
CARD Caspase9 Link Apaf1 Co-immunoprecipitation HEK293 Not specified Full length Not specified 1-412 9488720
CARD Caspase9 Link Apaf1 Co-immunoprecipitation HEK293 Not specified 1-168 Not specified 1-412 9488720
CARD Caspase9 Link Apaf1 Co-immunoprecipitation HEK293 Human Not specified Not specified Full length 9539746
CARD Caspase9 Link Apaf1 Co-immunoprecipitation HEK293 Human Not specified Not specified 1-559 9539746
CARD Caspase9 Link Apaf1 Co-immunoprecipitation Rat cardiomyocyte 15253891
CARD Caspase9 Link Apaf1 Size-exclusion chromatography HEK293 10617566
CARD Caspase9 Link Apaf1 Size-exclusion chromatography Human monocytic tumor cell 10692394
CARD Caspase9 Link Apaf1 Size-exclusion chromatography THP-1 11550094
CARD Caspase9 Link Apaf1 Size-exclusion chromatography HeLa 12460989
CARD Caspase9 Link Apaf1 Size-exclusion chromatography Rat cortex 14602082
CARD Caspase9 Link CARD8 Co-immunoprecipitation HEK293 Not specified Not specified Human Full length 11408476
CARD Caspase9 Link CIAP1 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 9545235
CARD Caspase9 Link CIAP2 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 9545235
CARD Caspase9 Link NOD1 Co-immunoprecipitation HEK293 Not specified Not specified Human Full length 10329646
CARD CIAP1 Link Caspase9 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 9545235
CARD CIAP1 Link RIPK2 Co-immunoprecipitation HEK293 Not specified Not specified Human Not specified 9642260
CARD CIAP1 Link RIPK2 Co-immunoprecipitation HEK293 Not specified Not specified Human 2-540 9705938
CARD CIAP1 Link RIPK2 Co-immunoprecipitation HEK293 Not specified Full length Not specified Full length 19464198
CARD CIAP1 Link RIPK2 Co-immunoprecipitation HEK239 Not specified Not specified Human Not specified 21931591
CARD CIAP2 Link Bcl-10 Co-immunoprecipitation Rat brain hippocampus 12786973
CARD CIAP2 Link Bcl-10 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 16775419
CARD CIAP2 Link Caspase9 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 9545235
CARD CIAP2 Link RIPK2 Co-immunoprecipitation HEK293 Not specified Not specified Human 2-540 9705938
CARD CIAP2 Link RIPK2 Co-immunoprecipitation HEK293 Not specified Full length Not specified Full length 19464198
CARD CIAP2 Link RIPK2 Co-immunoprecipitation HEK239 Not specified Not specified Human Not specified 21931591
CARD MAVS Link MAVS Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 19036819
CARD MAVS Link MAVS Fluorescence resonance energy transfer Huh 7 Not specified Not specified Not specified Not specified 19036819
CARD MAVS Link MDA5 Co-immunoprecipitation HEK293 Human Not specified Human 1-575 16127453
CARD MAVS Link RIG-1 Co-immunoprecipitation HEK293 Human Not specified Human 1-604 16127453
CARD MAVS Link RIG-1 Co-immunoprecipitation HEK293 Human Full length Not specified Not specified 16177806
CARD MAVS Link RIG-1 Co-immunoprecipitation HEK293 Human Not specified Not specified Not specified 17020950
CARD MAVS Link RIG-1 Co-immunoprecipitation HEK293 Not used Not specified Not specified 21419663
CARD MAVS Link RIG-1 Fluorescence resonance energy transfer Huh 7 Not specified Not specified Not specified Not specified 19036819
CARD MDA5 Link MAVS Co-immunoprecipitation HEK293 Human 1-575 Human Not specified 16127453
CARD MDA5 Link RIG-1 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 22328336
CARD NLRP1 Link Apaf1 Co-immunoprecipitation HEK293 Not specified Full length Not specified Full length 11113115
CARD NLRP1 Link Apaf1 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 17418785
CARD NLRP1 Link CARD12 Co-immunoprecipitation HEK293 Not specified Not specified Human Not specified 11472070
CARD NLRP1 Link CARD6 Co-immunoprecipitation HEK293 Not specified Full length Human 1-311 12775719
CARD NLRP1 Link Caspase1 Co-immunoprecipitation HEK293 Human Full length Human Not specified 17349957
CARD NLRP1 Link Caspase1 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 17418785
CARD NLRP1 Link Caspase1 Co-immunoprecipitation Rat cortical lysate 19401709
CARD NLRP1 Link Caspase1 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 21252346
CARD NLRP1 Link Caspase1 Size-exclusion chromatography Mice cerebral cortex 19066616
CARD NLRP1 Link Caspase2 Co-immunoprecipitation HEK293 Human Full length Not specified Not specified 11076957
CARD NLRP1 Link Caspase2 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 12191486
CARD NLRP1 Link Caspase4 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 12191486
CARD NLRP1 Link Caspase5 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 12191486
CARD NLRP1 Link Caspase5 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 17418785
CARD NLRP1 Link NLRP1 Co-immunoprecipitation HEK293 Not specified Full length Not specified Full length 11113115
CARD NLRP1 Link NLRP1 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 21252346
CARD NOD1 Link CARD6 Co-immunoprecipitation HEK293 Not specified Not specified Human 1-311 12775719
CARD NOD1 Link Caspase1 Co-immunoprecipitation HEK293 Human Full length Not specified Not specified 10329646
CARD NOD1 Link Caspase1 Co-immunoprecipitation HEK293 Not specified 1-158 Not specified 1-102 12459189
CARD NOD1 Link Caspase2 Co-immunoprecipitation HEK293 Human Full length Not specified Not specified 10329646
CARD NOD1 Link Caspase4 Co-immunoprecipitation HEK293 Human Full length Not specified Not specified 10329646
CARD NOD1 Link Caspase9 Co-immunoprecipitation HEK293 Human Full length Not specified Not specified 10329646
CARD NOD1 Link NOD1 Co-immunoprecipitation HEK293 Human Full length Human Full length 10329646
CARD NOD1 Link NOD1 Co-immunoprecipitation HEK293 Not specified Full length Not specified 1-648 10880512
CARD NOD1 Link NOD1 Co-immunoprecipitation HEK293 Not specified 1-648 Not specified 1-648 10880512
CARD NOD1 Link RIPK2 Co-immunoprecipitation HEK293 Human Full length Not specified Full length 10224040
CARD NOD1 Link RIPK2 Co-immunoprecipitation HEK293 Human Full length Not specified 374-540 10329646
CARD NOD1 Link RIPK2 Co-immunoprecipitation HEK293 Human Full length Not specified Not specified 11463746
CARD NOD1 Link RIPK2 Co-immunoprecipitation HEK293 Not specified 1-158 Not specified 365-531 12459189
CARD NOD1 Link RIPK2 Co-immunoprecipitation HEK293 Human Full length Not specified Full length 17054981
CARD NOD2 Link CARD12 Co-immunoprecipitation HEK293 Not specified Not specified Human Not specified 11472070
CARD NOD2 Link Caspase1 Co-immunoprecipitation HEK293 Not specified Full length Not specified Full length 18511561
CARD NOD2 Link RIG-1 Co-Immunofluorescence staining HT29 21690088
CARD NOD2 Link RIG-1 Co-Immunofluorescence staining HEK293 Not specified Not specified Not specified Not specified 21690088
CARD NOD2 Link RIG-1 Co-immunoprecipitation HEK293 Not specified Full length Not specified Full length 21690088
CARD NOD2 Link RIG-1 Co-immunoprecipitation HEK293 Not specified 1-301 Not specified Full length 21690088
CARD NOD2 Link RIG-1 Co-immunoprecipitation HEK293 Not specified 1-301 Not specified 1-225 21690088
CARD NOD2 Link RIG-1 Co-immunoprecipitation HEK293 Not specified Full length Not specified 1-225 21690088
CARD NOD2 Link RIPK2 Co-immunoprecipitation HEK293 Human Full length Not specified Full length 11087742
CARD NOD2 Link RIPK2 Co-immunoprecipitation HEK293 Human 1-744 Not specified Full length 11087742
CARD NOD2 Link RIPK2 Co-immunoprecipitation HEK293 Human 1-301 Not specified Full length 11087742
CARD NOD2 Link RIPK2 Co-immunoprecipitation HEK293 Human Full length Not specified 374-540 11087742
CARD NOD2 Link RIPK2 Co-immunoprecipitation HEK293 Mouse Not specified Not specified Not specified 15620648
CARD NOD2 Link RIPK2 Co-immunoprecipitation HEK293 Mouse Not specified Not specified Not specified 18775659
CARD NOD2 Link RIPK2 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Full length 19464198
CARD NOD2 Link RIPK2 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 22665475
CARD NOL3 Link Caspase2 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 9560245
CARD RAIDD Link Bcl-10 Co-immunoprecipitation HEK293 Not used Not specified Not specified 22323537
CARD RAIDD Link Caspase2 Co-Immunofluorescence staining HEK293 Human Full length Mouse Full length 10713730
CARD RAIDD Link Caspase2 Co-immunoprecipitation HEK293 Not specified Not specified Human Full length 8985253
CARD RAIDD Link Caspase2 Co-immunoprecipitation HEK293 Human Full length Mouse Full length 10713730
CARD RAIDD Link Caspase2 Co-immunoprecipitation Namalwa Not specified Not specified Human Not specified 11156409
CARD RAIDD Link Caspase2 Co-immunoprecipitation Mouse brain cell 11978827
CARD RAIDD Link Caspase2 Co-immunoprecipitation HEK293 Not specified Full length Not specified 1-104 15073321
CARD RAIDD Link Caspase2 Co-immunoprecipitation HCL116 16652156
CARD RAIDD Link Caspase2 Co-immunoprecipitation Hippocampal CA1 subregion 18845684
CARD RAIDD Link Caspase2 Co-immunoprecipitation HEK293 Not specified Not specified Not specified 1-122 19782032
CARD RAIDD Link Caspase2 Co-immunoprecipitation rat hippocampal neuron 22515271
CARD RIG-1 Link Caspase12 Co-Immunofluorescence staining Mouse embryonic fibroblast Human Not specified Not specified Not specified 20818395
CARD RIG-1 Link Caspase12 GST fusion protein pull-down Mouse embryonic fibroblast Human Not specified Not specified Not specified 20818395
CARD RIG-1 Link MAVS Co-immunoprecipitation HEK293 Human 1-604 Human Not specified 16127453
CARD RIG-1 Link MAVS Co-immunoprecipitation HEK293 Not specified Not specified Human Full length 16177806
CARD RIG-1 Link MAVS Co-immunoprecipitation HEK293 Not specified Not specified Human Not specified 17020950
CARD RIG-1 Link MAVS Co-immunoprecipitation HEK293 Not specified Not specified Not used 21419663
CARD RIG-1 Link MAVS Fluorescence resonance energy transfer Huh 7 Not specified Not specified Not specified Not specified 19036819
CARD RIG-1 Link MDA5 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 22328336
CARD RIG-1 Link NOD2 Co-Immunofluorescence staining HT29 21690088
CARD RIG-1 Link NOD2 Co-Immunofluorescence staining HEK293 Not specified Not specified Not specified Not specified 21690088
CARD RIG-1 Link NOD2 Co-immunoprecipitation HEK293 Not specified Full length Not specified Full length 21690088
CARD RIG-1 Link NOD2 Co-immunoprecipitation HEK293 Not specified Full length Not specified 1-301 21690088
CARD RIG-1 Link NOD2 Co-immunoprecipitation HEK293 Not specified 1-225 Not specified 1-301 21690088
CARD RIG-1 Link NOD2 Co-immunoprecipitation HEK293 Not specified 1-225 Not specified Full length 21690088
CARD RIPK2 Link ASC Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 14634131
CARD RIPK2 Link Bcl-10 Co-immunoprecipitation HEK293 Not specified Full length Human Full length 14638696
CARD RIPK2 Link Bcl-10 Co-immunoprecipitation HEK293 Human Full length Not specified Full length 14638696
CARD RIPK2 Link CARD16 Co-immunoprecipitation HEK293 Not specified Full length Human Not specified 11432859
CARD RIPK2 Link CARD16 Co-immunoprecipitation HEK293 Not specified Not specified Human 1-106 11536016
CARD RIPK2 Link CARD18 Co-immunoprecipitation HEK293 Not specified Not specified Human Full length 11536016
CARD RIPK2 Link CARD6 Co-immunoprecipitation HEK293 Not specified Not specified Human 1-311 12775719
CARD RIPK2 Link CARD9 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 17486093
CARD RIPK2 Link Caspase1 Co-immunoprecipitation HEK293 Human 2-92 Human 2-540 9705938
CARD RIPK2 Link Caspase1 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Full length 11051551
CARD RIPK2 Link Caspase1 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 11536016
CARD RIPK2 Link Caspase1 Co-immunoprecipitation HEK293 Murine Not specified Human 2-540 15039421
CARD RIPK2 Link Caspase1 Co-immunoprecipitation HEK293 Murine Not specified Human 431-540 15039421
CARD RIPK2 Link Caspase1 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 16585594
CARD RIPK2 Link Caspase1 Co-immunoprecipitation THP-1 16585594
CARD RIPK2 Link Caspase1 Co-immunoprecipitation HEK239 Not specified Not specified Human Not specified 21862576
CARD RIPK2 Link CIAP1 Co-immunoprecipitation HEK293 Human Not specified Not specified Not specified 9642260
CARD RIPK2 Link CIAP1 Co-immunoprecipitation HEK293 Human 2-540 Not specified Not specified 9705938
CARD RIPK2 Link CIAP1 Co-immunoprecipitation HEK293 Not specified Full length Not specified Full length 19464198
CARD RIPK2 Link CIAP1 Co-immunoprecipitation HEK239 Human Not specified Not specified Not specified 21931591
CARD RIPK2 Link CIAP2 Co-immunoprecipitation HEK293 Human 2-540 Not specified Not specified 9705938
CARD RIPK2 Link CIAP2 Co-immunoprecipitation HEK293 Not specified Full length Not specified Full length 19464198
CARD RIPK2 Link CIAP2 Co-immunoprecipitation HEK239 Human Not specified Not specified Not specified 21931591
CARD RIPK2 Link NOD1 Co-immunoprecipitation HEK293 Not specified Full length Human Full length 10224040
CARD RIPK2 Link NOD1 Co-immunoprecipitation HEK293 Not specified 374-540 Human Full length 10329646
CARD RIPK2 Link NOD1 Co-immunoprecipitation HEK293 Not specified Not specified Human Full length 11463746
CARD RIPK2 Link NOD1 Co-immunoprecipitation HEK293 Not specified 365-531 Not specified 1-158 12459189
CARD RIPK2 Link NOD1 Co-immunoprecipitation HEK293 Not specified Full length Human Full length 17054981
CARD RIPK2 Link NOD2 Co-immunoprecipitation HEK293 Not specified Full length Human Full length 11087742
CARD RIPK2 Link NOD2 Co-immunoprecipitation HEK293 Not specified Full length Human 1-744 11087742
CARD RIPK2 Link NOD2 Co-immunoprecipitation HEK293 Not specified Full length Human 1-301 11087742
CARD RIPK2 Link NOD2 Co-immunoprecipitation HEK293 Not specified 374-540 Human Full length 11087742
CARD RIPK2 Link NOD2 Co-immunoprecipitation HEK293 Not specified Not specified Mouse Not specified 15620648
CARD RIPK2 Link NOD2 Co-immunoprecipitation HEK293 Not specified Not specified Mouse Not specified 18775659
CARD RIPK2 Link NOD2 Co-immunoprecipitation HEK293 Not specified Full length Not specified Not specified 19464198
CARD RIPK2 Link NOD2 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 22665475
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Characterization
  Stoichiometry Affinity Protein-Protein interface Reference
Family DD1 DD2 Method Mutation Complex structure
CARD Apaf1 Link Caspase9 Structure 1:1 D27A, E40A (Apaf1) R13A, R56A (Caspase9) 3YGS 10376594
CARD Apaf1 Link Caspase9 Gel filtration 1:1 11904389
CARD ASC Link Caspase1 Co-immunoprecipitation L122Q(ASC) 14634131
CARD ASC Link Caspase1 Co-immunoprecipitation D27G, R45D (Caspase1) 21862576
CARD ASC Link RIPK2 Co-immunoprecipitation L122Q(ASC) 14634131
CARD Bcl-10 Link Bcl-10 Co-immunoprecipitation L41R(Bcl-10) 10364242
CARD Bcl-10 Link Bcl-10 Fluorescence probe labeling 3.0μM 19538180
CARD Bcl-10 Link Bcl-10 GST fusion protein pull-down L47A, I46A, L41A, I55A (Bcl-10) 10187815
CARD Bcl-10 Link BinCARD GST fusion protein pull-down L65A (BinCARD) 15637807
CARD Bcl-10 Link CARD11 Co-immunoprecipitation L39R (CARD11) 12154360
CARD Bcl-10 Link CARD11 Co-immunoprecipitation S109A (CARD11) 16809782
CARD Bcl-10 Link CARMA1 Co-immunoprecipitation R35A (CARMA1) E53A, E54A (Bcl-10) 22880103
CARD BinCARD Link Bcl-10 GST fusion protein pull-down L65A (BinCARD) 15637807
CARD CARD11 Link Bcl-10 Co-immunoprecipitation L39R (CARD11) 12154360
CARD CARD11 Link Bcl-10 Co-immunoprecipitation S109A (CARD11) 16809782
CARD CARMA1 Link Bcl-10 Co-immunoprecipitation R35A (CARMA1) E53A, E54A (Bcl-10) 22880103
CARD Caspase1 Link ASC Co-immunoprecipitation L122Q(ASC) 14634131
CARD Caspase1 Link ASC Co-immunoprecipitation D27G, R45D (Caspase1) 21862576
CARD Caspase1 Link Caspase1 Co-immunoprecipitation D27G, R45D (Caspase1) 21862576
CARD Caspase1 Link RIPK2 Co-immunoprecipitation D27G, R45D (Caspase1) 21862576
CARD Caspase9 Link Apaf1 Structure 1:1 D27A, E40A (Apaf1) R13A, R56A (Caspase9) 3YGS 10376594
CARD Caspase9 Link Apaf1 Gel filtration 1:1 11904389
CARD Caspase9 Link NOD1 Co-immunoprecipitation V41Q(NOD1) 10329646
CARD NOD1 Link Caspase9 Co-immunoprecipitation V41Q(NOD1) 10329646
CARD NOD1 Link NOD1 Co-immunoprecipitation V41Q(NOD1) 10880512
CARD NOD1 Link RIPK2 Co-immunoprecipitation V41Q(NOD1) 10329646
CARD NOD1 Link RIPK2 Co-immunoprecipitation E53K, D54K, E56K (NOD1) R444E, R483E, R488E (RIPK2) 17054981
CARD NOD1 Link RIPK2 GST fusion protein pull-down D461A, E472A, E475A, E492A (RIPK2) 22470564
CARD NOD2 Link NOD2 Isothermal titration calorimety 1:1 1μM 22470564
CARD NOD2 Link RIPK2 GST fusion protein pull-down R38A, R86A (NOD2) D461A, E472A, D473A, E475A, D492A (RIPK2) 22470564
CARD NOD2 Link RIPK2 Yeast two-hybrid E69K, D70K (Nod2) 19337385
CARD RIPK2 Link ASC Co-immunoprecipitation L122Q(ASC) 14634131
CARD RIPK2 Link Caspase1 Co-immunoprecipitation D27G, R45D (Caspase1) 21862576
CARD RIPK2 Link NOD1 Co-immunoprecipitation V41Q(NOD1) 10329646
CARD RIPK2 Link NOD1 Co-immunoprecipitation E53K, D54K, E56K (NOD1) R444E, R483E, R488E (RIPK2) 17054981
CARD RIPK2 Link NOD1 GST fusion protein pull-down D461A, E472A, E475A, E492A (RIPK2) 22470564
CARD RIPK2 Link NOD2 GST fusion protein pull-down R38A, R86A (NOD2) D461A, E472A, D473A, E475A, D492A (RIPK2) 22470564
CARD RIPK2 Link NOD2 Yeast two-hybrid E69K, D70K (Nod2) 19337385
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Functional Role
Family DD1 DD2 Method Death-related Death-unrelated Reference
CARD Apaf1 Link Apaf1 Caspase cleaved assay Caspase9 activation 9837928
CARD Apaf1 Link Apaf1 Caspase cleaved assay Caspase9 activation 10944114
CARD Apaf1 Link Caspase9 β-galactosidase staining Apoptosis (Apoptosome) 9390557
CARD Apaf1 Link Caspase9 DAPI staining Apoptosis (Apoptosome) 9488720
CARD Apaf1 Link Caspase9 β-galactosidase staining Apoptosis (Apoptosome) 9539746
CARD Apaf1 Link Caspase9 DAPI staining Apoptosis (Apoptosome) 11408476
CARD Apaf1 Link Caspase9 Caspase cleaved assay Caspase9 activation 10206961
CARD Apaf1 Link Caspase9 Caspase cleaved assay Caspase9 activation (Apoptosome) 11904389
CARD Apaf1 Link Caspase9 Caspase cleaved assay Caspase9 activation 10617566
CARD Apaf1 Link NLRP1 DAPI staining Apoptosis 11113115
CARD ASC Link CARD12 β-galactosidase staining, Luciferase assay Apoptosis NF-kB activation 12646168
CARD ASC Link Caspase1 ELISA IL-1 secretion (Inflammasome) 11967258
CARD ASC Link Caspase1 ELISA IL-1b secretion (Inflammasome) 12019269
CARD ASC Link Caspase1 ELISA IL-1b secretion decrease 14634131
CARD ASC Link Caspase1 ELISA IL-1b secretion 16585594
CARD ASC Link Caspase1 Luciferase assay NF-kB activation 21862576
CARD ASC Link RIPK2 Immunoprecipitation Pro-caspase1-RIPK2 complex inhibition 14634131
CARD Bcl-10 Link Bcl-10 Luciferase assay NF-kB activation 10364242
CARD Bcl-10 Link BinCARD Luciferase assay NF-kB activation block 15637807
CARD Bcl-10 Link CARD10 Luciferase assay NF-kB activation (signalosome) 11259443
CARD Bcl-10 Link CARD10 Luciferase assay NF-kB activation (signalosome) 11387339
CARD Bcl-10 Link CARD11 Luciferase assay Bcl10 phosphorylation, NF-kB activation (Signalosome) 11356195
CARD Bcl-10 Link CARD11 Luciferase assay NF-kB activation (signalosome) 11278692
CARD Bcl-10 Link CARD11 Luciferase assay NF-kB activation (Signalosome) 12154360
CARD Bcl-10 Link CARD11 Luciferase assay NF-kB activation (Signalosome) 16809782
CARD Bcl-10 Link CARD11 Immunofluorescence staining NF-kB activation (Signalosome) 17478723
CARD Bcl-10 Link CARD11 Immunofluorescence staining NF-kB activation (Signalosome) 18802088
CARD Bcl-10 Link CARD14 Luciferase assay NF-kB activation (signalosome) 11278692
CARD Bcl-10 Link CARD9 Luciferase assay NF-kB activation (signalosome) 11053425
CARD Bcl-10 Link CARD9 EMSA NF-kB activation (Signalosome) 20538615
CARD Bcl-10 Link RAIDD Immunoprecipitation Bcl10-CARMA1 complex inhibition 22323537
CARD Bcl-10 Link RIPK2 Luciferase assay NF-kB activation 14638696
CARD BinCARD Link Bcl-10 Luciferase assay NF-kB activation block 15637807
CARD CARD10 Link Bcl-10 Luciferase assay NF-kB activation (signalosome) 11259443
CARD CARD10 Link Bcl-10 Luciferase assay NF-kB activation (signalosome) 11387339
CARD CARD11 Link Bcl-10 Luciferase assay Bcl10 phosphorylation, NF-kB activation (Signalosome) 11356195
CARD CARD11 Link Bcl-10 Luciferase assay NF-kB activation (signalosome) 11278692
CARD CARD11 Link Bcl-10 Luciferase assay NF-kB activation (Signalosome) 12154360
CARD CARD11 Link Bcl-10 Luciferase assay NF-kB activation (Signalosome) 16809782
CARD CARD11 Link Bcl-10 Immunofluorescence staining NF-kB activation (Signalosome) 17478723
CARD CARD11 Link Bcl-10 Immunofluorescence staining NF-kB activation (Signalosome) 18802088
CARD CARD12 Link ASC β-galactosidase staining, Luciferase assay Apoptosis NF-kB activation 12646168
CARD CARD12 Link Caspase1 β-galactosidase staining Pyroptosis (Inflammasome) 11390368
CARD CARD14 Link Bcl-10 Luciferase assay NF-kB activation (signalosome) 11278692
CARD CARD16 Link Caspase1 Immunoprecipitation, ELISA Rip mediated procaspase1 oligomerization inhibition, IL-1b secretion decrease 11432859
CARD CARD16 Link Caspase1 Immunoprecipitation Caspase1-RIPK2 complex interfere 11536016
CARD CARD16 Link RIPK2 Immunoprecipitation Caspase1-RIPK2 complex interfere 11536016
CARD CARD18 Link Caspase1 Immunoprecipitation Caspase1-RIPK2 complex interfere 11536016
CARD CARD18 Link Caspase1 Caspase1 binding assay RIPK2 ability inhibition 11051551
CARD CARD6 Link NOD1 Luciferase assay NF-kB activation block 12775719
CARD CARD6 Link RIPK2 Luciferase assay NF-kB activation block 12775719
CARD CARD8 Link Caspase1 Caspase cleaved assay, ELISA Caspase1 activation block, IL-1b secretion decrease 11821383
CARD CARD8 Link Caspase9 DAPI staining, Immunoprecipitation Apoptosis inhibition, Caspase9-Apaf1 complex inhibition 11408476
CARD CARD9 Link Bcl-10 Luciferase assay NF-kB activation (signalosome) 11053425
CARD CARD9 Link Bcl-10 EMSA NF-kB activation (Signalosome) 20538615
CARD CARD9 Link RIPK2 Western blotting Bcl-10 phosphorylation increase 17486093
CARD Caspase1 Link ASC ELISA IL-1 secretion (Inflammasome) 11967258
CARD Caspase1 Link ASC ELISA IL-1b secretion (Inflammasome) 12019269
CARD Caspase1 Link ASC ELISA IL-1b secretion decrease 14634131
CARD Caspase1 Link ASC ELISA IL-1b secretion 16585594
CARD Caspase1 Link ASC Luciferase assay NF-kB activation 21862576
CARD Caspase1 Link CARD12 β-galactosidase staining Pyroptosis (Inflammasome) 11390368
CARD Caspase1 Link CARD16 Immunoprecipitation, ELISA Rip mediated procaspase1 oligomerization inhibition, IL-1b secretion decrease 11432859
CARD Caspase1 Link CARD16 Immunoprecipitation Caspase1-RIPK2 complex interfere 11536016
CARD Caspase1 Link CARD18 Immunoprecipitation Caspase1-RIPK2 complex interfere 11536016
CARD Caspase1 Link CARD18 Caspase1 binding assay RIPK2 ability inhibition 11051551
CARD Caspase1 Link CARD8 Caspase cleaved assay, ELISA Caspase1 activation block, IL-1b secretion decrease 11821383
CARD Caspase1 Link Caspase12 Caspase cleaved assay Caspase12 activation 18332441
CARD Caspase1 Link NLRP1 Luciferase assay Caspase1 activation (Inflammasome) 17349957
CARD Caspase1 Link NLRP1 ELISA IL-1b secretion increase 17418785
CARD Caspase1 Link NLRP1 Caspase cleaved assay Caspase1 activation (Inflammasome) 21252346
CARD Caspase1 Link NOD1 Immunoprecipitation Caspase1 oligomerization enhance 12459189
CARD Caspase1 Link NOD2 Caspase cleaved assay Caspase1 activation 18511561
CARD Caspase1 Link RIPK2 Caspase cleaved assay Pro-caspase1 activation 9705938
CARD Caspase1 Link RIPK2 Caspase cleaved assay Caspase1 activation 11051551
CARD Caspase1 Link RIPK2 Reporter gene assay NF-kB activation 15039421
CARD Caspase1 Link RIPK2 Luciferase assay NF-kB activation 16585594
CARD Caspase12 Link Caspase1 Caspase cleaved assay Caspase12 activation 18332441
CARD Caspase2 Link RAIDD β-galactosidase staining Apoptosis (PIDDosome) 8985253
CARD Caspase2 Link RAIDD Trypan blue staining Apoptosis (PIDDosome) 15073321
CARD Caspase2 Link RAIDD TUNEL assay Apoptosis (PIDDosome) 18845684
CARD Caspase5 Link NLRP1 Caspase cleaved assay Caspase5 activation (Inflammasome) 12191486
CARD Caspase5 Link NLRP1 ELISA IL-1b secretion increase 17418785
CARD Caspase9 Link Apaf1 β-galactosidase staining Apoptosis (Apoptosome) 9390557
CARD Caspase9 Link Apaf1 DAPI staining Apoptosis (Apoptosome) 9488720
CARD Caspase9 Link Apaf1 β-galactosidase staining Apoptosis (Apoptosome) 9539746
CARD Caspase9 Link Apaf1 DAPI staining Apoptosis (Apoptosome) 11408476
CARD Caspase9 Link Apaf1 Caspase cleaved assay Caspase9 activation 10206961
CARD Caspase9 Link Apaf1 Caspase cleaved assay Caspase9 activation (Apoptosome) 11904389
CARD Caspase9 Link Apaf1 Caspase cleaved assay Caspase9 activation 10617566
CARD Caspase9 Link CARD8 DAPI staining, Immunoprecipitation Apoptosis inhibition, Caspase9-Apaf1 complex inhibition 11408476
CARD Caspase9 Link CIAP1 DAPI staining Apoptosis inhibition 9545235
CARD Caspase9 Link CIAP2 DAPI staining Apoptosis inhibition 9545235
CARD Caspase9 Link NOD1 Caspase cleaved assay, β-galactosidase staining Caspase9 activation, Caspase9 induced Apoptosis 10329646
CARD CIAP1 Link Caspase9 DAPI staining Apoptosis inhibition 9545235
CARD CIAP1 Link RIPK2 β-galactosidase staining Apoptosis inhibition 9642260
CARD CIAP2 Link Caspase9 DAPI staining Apoptosis inhibition 9545235
CARD MAVS Link MAVS Luciferase assay NF-kB activation 19036819
CARD MAVS Link MAVS Luciferase assay NF-kB activation 19036819
CARD MAVS Link MDA5 ELISA Type 1 interferon induced 16127453
CARD MAVS Link RIG-1 ELISA Type 1 interferon induced 16127453
CARD MAVS Link RIG-1 Luciferase assay IFN-b induced 16177806
CARD MDA5 Link MAVS ELISA Type 1 interferon induced 16127453
CARD NLRP1 Link Apaf1 DAPI staining Apoptosis 11113115
CARD NLRP1 Link Caspase1 Luciferase assay Caspase1 activation (Inflammasome) 17349957
CARD NLRP1 Link Caspase1 ELISA IL-1b secretion increase 17418785
CARD NLRP1 Link Caspase1 Caspase cleaved assay Caspase1 activation (Inflammasome) 21252346
CARD NLRP1 Link Caspase5 Caspase cleaved assay Caspase5 activation (Inflammasome) 12191486
CARD NLRP1 Link Caspase5 ELISA IL-1b secretion increase 17418785
CARD NOD1 Link CARD6 Luciferase assay NF-kB activation block 12775719
CARD NOD1 Link Caspase1 Immunoprecipitation Caspase1 oligomerization enhance 12459189
CARD NOD1 Link Caspase9 Caspase cleaved assay, β-galactosidase staining Caspase9 activation, Caspase9 induced Apoptosis 10329646
CARD NOD1 Link NOD1 Luciferase assay NF-kB activation(Nodosome) 10880512
CARD NOD1 Link RIPK2 Luciferase assay NF-kB activation 10329646
CARD NOD1 Link RIPK2 Reporter gene assay NF-kB activation (Nodosome) 11463746
CARD NOD2 Link Caspase1 Caspase cleaved assay Caspase1 activation 18511561
CARD NOD2 Link RIG-1 Reporter gene assay NF-kB activation block, IFN-b activation block 21690088
CARD NOD2 Link RIPK2 Luciferase assay NF-kB activation(Nodosome) 11087742
CARD NOD2 Link RIPK2 ELISA NF-kB activation (Nodosome) 18775659
CARD RAIDD Link Bcl-10 Immunoprecipitation Bcl10-CARMA1 complex inhibition 22323537
CARD RAIDD Link Caspase2 β-galactosidase staining Apoptosis (PIDDosome) 8985253
CARD RAIDD Link Caspase2 Trypan blue staining Apoptosis (PIDDosome) 15073321
CARD RAIDD Link Caspase2 TUNEL assay Apoptosis (PIDDosome) 18845684
CARD RIG-1 Link MAVS ELISA Type 1 interferon induced 16127453
CARD RIG-1 Link MAVS Luciferase assay IFN-b induced 16177806
CARD RIG-1 Link NOD2 Reporter gene assay NF-kB activation block, IFN-b activation block 21690088
CARD RIPK2 Link ASC Immunoprecipitation Pro-caspase1-RIPK2 complex inhibition 14634131
CARD RIPK2 Link Bcl-10 Luciferase assay NF-kB activation 14638696
CARD RIPK2 Link CARD16 Immunoprecipitation Caspase1-RIPK2 complex interfere 11536016
CARD RIPK2 Link CARD6 Luciferase assay NF-kB activation block 12775719
CARD RIPK2 Link CARD9 Western blotting Bcl-10 phosphorylation increase 17486093
CARD RIPK2 Link Caspase1 Caspase cleaved assay Pro-caspase1 activation 9705938
CARD RIPK2 Link Caspase1 Caspase cleaved assay Caspase1 activation 11051551
CARD RIPK2 Link Caspase1 Reporter gene assay NF-kB activation 15039421
CARD RIPK2 Link Caspase1 Luciferase assay NF-kB activation 16585594
CARD RIPK2 Link CIAP1 β-galactosidase staining Apoptosis inhibition 9642260
CARD RIPK2 Link NOD1 Luciferase assay NF-kB activation 10329646
CARD RIPK2 Link NOD1 Reporter gene assay NF-kB activation (Nodosome) 11463746
CARD RIPK2 Link NOD2 Luciferase assay NF-kB activation(Nodosome) 11087742
CARD RIPK2 Link NOD2 ELISA NF-kB activation (Nodosome) 18775659
(Link: click this icon to show interactions only between the two corresponding DDs)
  » Citation