CIAP1 (CARD)

Full Name:
Baculoviral IAP repeat-containing protein 2
Alternative Names:
API1, MIHB, HIAP2, RNF48, BIRC2, Hiap-2, c-IAP1
Function:
Apoptotic suppressor. The BIR motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form an heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2).
Death Domain Subfamily & Boundary Region:
Species External DB Questionmark
Uniprot DIP STRING KEGG IntAct MINT
Human Seq Q13490external db link DIP-33485Nexternal db link Q13490external db link hsa:329external db link Q13490external db link MINT-216174external db link
Mouse Seq Q62210external db link Q62210external db link mmu:11797external db link Q62210external db link MINT-2839737external db link
Rat Seq Q6P6S1external db link Q6P6S1external db link rno:60371external db link
Dog Seq Q38JA8external db link Q38JA8external db link cfa:479464external db link
Zebra fish Seq Q8UWD2external db link Q8UWD2external db link dre:373107external db link
Structure Species Residue Method Expression Purification Column Final condition Final concentration Reference
2L9M Download Human 435-543 NMR Affinity chromatography 20mM sodium phosphate(pH7.5), 50mM NaCl, 5mM TCEP, 0.02% sodium azide 1mM 21549626
3T6P Download Human 266-618 X-ray E.coli Gel filtration Superdex 75 9mg/ml 22021857
No information
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vitro interaction
  DD1 DD2 Reference
Family DD1 DD2 Method Species Region Expression Species Region Expression
CARD CIAP1 Link Caspase9 GST fusion protein pull-down Not specified Not specified U937 Not specified Not specified In vitro translation 9545235
CARD CIAP1 Link RIPK2 GST fusion protein pull-down Not specified Not specified E.coli Not specified Full length In vitro translation 19464198
CARD CIAP1 Link RIPK2 GST fusion protein pull-down Not specified Not specified E.coli Human Not specified In vitro translation 21931591
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
CARD CIAP1 Link Caspase9 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 9545235
CARD CIAP1 Link RIPK2 Co-immunoprecipitation HEK293 Not specified Not specified Human Not specified 9642260
CARD CIAP1 Link RIPK2 Co-immunoprecipitation HEK293 Not specified Not specified Human 2-540 9705938
CARD CIAP1 Link RIPK2 Co-immunoprecipitation HEK293 Not specified Full length Not specified Full length 19464198
CARD CIAP1 Link RIPK2 Co-immunoprecipitation HEK239 Not specified Not specified Human Not specified 21931591
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Functional Role
Family DD1 DD2 Method Death-related Death-unrelated Reference
CARD CIAP1 Link Caspase9 DAPI staining Apoptosis inhibition 9545235
CARD CIAP1 Link RIPK2 β-galactosidase staining Apoptosis inhibition 9642260
(Link: click this icon to show interactions only between the two corresponding DDs)