CIAP2 (CARD)

Full Name:
Baculoviral IAP repeat-containing protein 3
Alternative Names:
API2, MIHC, CIAP2, HIAP1, BIRC3, MALT2, RNF49, c-IAP2
Function:
Apoptotic suppressor. The BIR motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form an heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2).
Death Domain Subfamily & Boundary Region:
Species External DB Questionmark
Uniprot DIP STRING KEGG IntAct MINT
Human Seq Q13489external db link DIP:33720Nexternal db link Q13489external db link hsa:330external db link Q13489external db link
Mouse Seq O08863external db link O08863external db link O08863external db link MINT-1581324external db link
Rat Seq Q5XIW4external db link Q5XIW4external db link rno:78971external db link
Dog Seq A1E2V0external db link A1E2V0external db link cfa:489433external db link
Not solved yet
No information
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vitro interaction
  DD1 DD2 Reference
Family DD1 DD2 Method Species Region Expression Species Region Expression
CARD CIAP2 Link Caspase9 GST fusion protein pull-down Not specified Not specified U937 Not specified Not specified In vitro translation 9545235
CARD CIAP2 Link RIPK2 GST fusion protein pull-down Not specified Not specified E.coli Not specified Full length In vitro translation 19464198
CARD CIAP2 Link RIPK2 GST fusion protein pull-down Not specified Not specified E.coli Human Not specified In vitro translation 21931591
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
CARD CIAP2 Link Bcl-10 Co-immunoprecipitation Rat brain hippocampus 12786973
CARD CIAP2 Link Bcl-10 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 16775419
CARD CIAP2 Link Caspase9 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 9545235
CARD CIAP2 Link RIPK2 Co-immunoprecipitation HEK293 Not specified Not specified Human 2-540 9705938
CARD CIAP2 Link RIPK2 Co-immunoprecipitation HEK293 Not specified Full length Not specified Full length 19464198
CARD CIAP2 Link RIPK2 Co-immunoprecipitation HEK239 Not specified Not specified Human Not specified 21931591
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Functional Role
Family DD1 DD2 Method Death-related Death-unrelated Reference
CARD CIAP2 Link Caspase9 DAPI staining Apoptosis inhibition 9545235
(Link: click this icon to show interactions only between the two corresponding DDs)