Caspase10 (DED)

Full Name:
Caspase-10
Alternative Names:
MCH4, ALPS2, FLICE2, CASP10
Function:
Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas-and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small-molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC.Isoform C is proteolytically inactive.
Death Domain Subfamily & Boundary Region:
  • DED : 19-97, 114-187 Seq
Species External DB Questionmark
Uniprot DIP STRING KEGG IntAct MINT
Human Seq Q92851external db link DIP-33476Nexternal db link Q92851external db link hsa:843external db link Q92851external db link MINT-201954external db link
Not solved yet
Disease Mutation in disease Reference
Autoimmune lymphoproliferative syndrome (ALPS) L242F 10412980
Autoimmune lymphoproliferative syndrome (ALPS) L285F, I406L, V410I, Y446C 16446975
Gastric cancer M147T, Q257X 11973654
Non-hodgkin lymphoma A414V, Q257X, 367fs 12010812
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vitro interaction
  DD1 DD2 Reference
Family DD1 DD2 Method Species Region Expression Species Region Expression
DED Caspase10 Link FADD GST fusion protein pull-down HuH-7 lysate Not specified Full length E.coli 12407100
DED Caspase10 Link FADD His fusion protein pull-down Human Not specified In vitro translation Not specified Not specified Not specified 9045686
DED Caspase10 Link FLIP GST fusion protein pull-down Not specified Not specified In vitro translation Human Full length Not specified 9228018
DED Caspase10 Link FLIP Yeast two-hybrid Human Full length Yeast Human 1-215 Yeast 9208847
DED Caspase10 Link FLIP Yeast two-hybrid Not specified 18-189 Yeast Human 1-160 Yeast 9228018
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
DED Caspase10 Link Caspase8 Co-immunoprecipitation HT1080 12887920
DED Caspase10 Link Caspase8 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 12887920
DED Caspase10 Link Caspase8 Co-immunoprecipitation SKW6.4 17159907
DED Caspase10 Link Caspase8 Fluorescence resonance energy transfer Jurkat Not specified Full length Not specified Full length 11717445
DED Caspase10 Link DEDD2 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Full length 12527898
DED Caspase10 Link FADD Co-immunoprecipitation HEK293 Human Not specified Not specified Not specified 9045686
DED Caspase10 Link FADD Fluorescence resonance energy transfer HEK293 Not specified Full length Not specified Not specified 11717445
DED Caspase10 Link FLIP Co-immunoprecipitation HEK293 Not specified Not specified Human Full length 9211860
DED Caspase10 Link FLIP Co-immunoprecipitation HEK293 Not specified 18-189 Human Full length 9228018
DED Caspase10 Link FLIP Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 12887920
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Functional Role
Family DD1 DD2 Method Death-related Death-unrelated Reference
DED Caspase10 Link FADD DAPI staining Apoptosis (DISC) 9045686
DED Caspase10 Link FLIP β-galactosidase staining Apoptosis inhibition 9228018
(Link: click this icon to show interactions only between the two corresponding DDs)