Caspase12 (CARD)

Full Name:
Inactive caspase-12
Alternative Names:
CASP-12, CASP12P1, CASP12
Function:
Has no protease activity. May reduce cytokine release in response to bacterial lipopolysaccharide during infections. Reduces activation of NF-kappa-B in response to TNF.
Death Domain Subfamily & Boundary Region:
Species External DB Questionmark
Uniprot DIP STRING KEGG IntAct MINT
Human Seq Q6UXS9external db link hsa:100506742external db link
Mouse Seq O08736external db link O08736external db link mmu:12364external db link
Rat Seq Q920D5external db link DIP-29839Nexternal db link Q920D5external db link rno:156117external db link Q920D5external db link
Dog Seq Q075B4external db link Q075B4external db link cfa:479458external db link
Not solved yet
Disease Mutation in disease Reference
Sepsis T125C 15129283
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
CARD Caspase12 Link Caspase1 Co-immunoprecipitation HEK293 Rodent Not specified Not specified Not specified 16625199
CARD Caspase12 Link Caspase1 Co-immunoprecipitation HEK293 Rat Full length Not specified Not specified 18332441
CARD Caspase12 Link Caspase12 Co-immunoprecipitation HEK293 Mouse Full length Mouse Full length 11278723
CARD Caspase12 Link RIG-1 Co-Immunofluorescence staining Mouse embryonic fibroblast Not specified Not specified Human Not specified 20818395
CARD Caspase12 Link RIG-1 GST fusion protein pull-down Mouse embryonic fibroblast Not specified Not specified Human Not specified 20818395
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Functional Role
Family DD1 DD2 Method Death-related Death-unrelated Reference
CARD Caspase12 Link Caspase1 Caspase cleaved assay Caspase12 activation 18332441
(Link: click this icon to show interactions only between the two corresponding DDs)