Caspase2 (CARD)

Full Name:
Caspase-2
Alternative Names:
ICH1, NEDD2, CASP-2, ICH-1L, ICH-1L/1S, CASP2
Function:
Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival.
Death Domain Subfamily & Boundary Region:
Species External DB Questionmark
Uniprot DIP STRING KEGG IntAct MINT
Human Seq P42575external db link DIP-34552Nexternal db link P42575external db link hsa:835external db link P42575external db link MINT-150255external db link
Mouse Seq P29594external db link P29594external db link mmu:12366external db link
Rat Seq P55215external db link DIP-48602Nexternal db link P55215external db link rno:64314external db link
Zebra fish Seq Q0PKX3external db link Q0PKX3external db link dre:373118external db link
Not solved yet
No information
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vitro interaction
  DD1 DD2 Reference
Family DD1 DD2 Method Species Region Expression Species Region Expression
CARD Caspase2 Link Caspase2 Yeast two-hybrid Human 32-121 Yeast Human 32-121 Yeast 19337385
CARD Caspase2 Link RAIDD GST fusion protein pull-down Not specified Not specified In vitro translation Human Not specified E.coli 9044836
CARD Caspase2 Link RAIDD His fusion protein pull-down Human Full length In vitro translation Not specified Not specified E.coli 8985253
CARD Caspase2 Link RAIDD His fusion protein pull-down Human Full length In vitro translation Not specified 1-117 E.coli 8985253
CARD Caspase2 Link RAIDD His fusion protein pull-down Human 1-140 In vitro translation Not specified Not specified E.coli 8985253
CARD Caspase2 Link RAIDD In vitro purification protein assembly(Native gel-electrophoresis) Human 31-121 E.coli Human Full length E.coli 20872280
CARD Caspase2 Link RAIDD In vitro purification protein assembly(Size-exclusion chromatography) Not specified 1-104 HEK293 Not specified Full length HEK293 15073321
CARD Caspase2 Link RAIDD In vitro purification protein assembly(Size-exclusion chromatography) Human 31-121 E.coli Human Full length E.coli 20872280
CARD Caspase2 Link RAIDD Yeast two-hybrid Human Not specified Yeast Not specified Not specified Yeast 11156409
(Link: click this icon to show interactions only between the two corresponding DDs)
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In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
CARD Caspase2 Link Apaf1 Size-exclusion chromatography HeLa 12460989
CARD Caspase2 Link Caspase2 Bimolecular fluorescence complementation HeLa Not specified 1-122 Not specified 1-122 19782032
CARD Caspase2 Link NLRP1 Co-immunoprecipitation HEK293 Not specified Not specified Human Full length 11076957
CARD Caspase2 Link NLRP1 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 12191486
CARD Caspase2 Link NOD1 Co-immunoprecipitation HEK293 Not specified Not specified Human Full length 10329646
CARD Caspase2 Link NOL3 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 9560245
CARD Caspase2 Link RAIDD Co-Immunofluorescence staining HEK293 Mouse Full length Human Full length 10713730
CARD Caspase2 Link RAIDD Co-immunoprecipitation HEK293 Human Full length Not specified Not specified 8985253
CARD Caspase2 Link RAIDD Co-immunoprecipitation HEK293 Mouse Full length Human Full length 10713730
CARD Caspase2 Link RAIDD Co-immunoprecipitation Namalwa Human Not specified Not specified Not specified 11156409
CARD Caspase2 Link RAIDD Co-immunoprecipitation Mouse brain cell 11978827
CARD Caspase2 Link RAIDD Co-immunoprecipitation HEK293 Not specified 1-104 Not specified Full length 15073321
CARD Caspase2 Link RAIDD Co-immunoprecipitation HCL116 16652156
CARD Caspase2 Link RAIDD Co-immunoprecipitation Hippocampal CA1 subregion 18845684
CARD Caspase2 Link RAIDD Co-immunoprecipitation HEK293 Not specified 1-122 Not specified Not specified 19782032
CARD Caspase2 Link RAIDD Co-immunoprecipitation rat hippocampal neuron 22515271
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Functional Role
Family DD1 DD2 Method Death-related Death-unrelated Reference
CARD Caspase2 Link RAIDD β-galactosidase staining Apoptosis (PIDDosome) 8985253
CARD Caspase2 Link RAIDD Trypan blue staining Apoptosis (PIDDosome) 15073321
CARD Caspase2 Link RAIDD TUNEL assay Apoptosis (PIDDosome) 18845684
(Link: click this icon to show interactions only between the two corresponding DDs)