Caspase4 (CARD)

Full Name:
Caspase-4
Alternative Names:
TX, ICH-2, Mih1/TX, ICEREL-II, ICE(rel)II, CASP4
Function:
Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves caspase-1.
Death Domain Subfamily & Boundary Region:
Species External DB Questionmark
Uniprot DIP STRING KEGG IntAct MINT
Human Seq P49662external db link DIP-44806Nexternal db link P49662external db link hsa:837external db link P49662external db link
Mouse Seq P70343external db link P70343external db link mmu:12363external db link
Rat Seq Q3MHS1external db link Q3MHS1external db link rno:114555external db link
Not solved yet
No information
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
CARD Caspase4 Link Apaf1 Co-immunoprecipitation HEK293 Human Not specified Not specified Full length 9539746
CARD Caspase4 Link NLRP1 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 12191486
CARD Caspase4 Link NOD1 Co-immunoprecipitation HEK293 Not specified Not specified Human Full length 10329646
(Link: click this icon to show interactions only between the two corresponding DDs)