DAPK1 (DD)

Full Name:
Death-associated protein kinase 1
Alternative Names:
DAPK, DKFZp781I035, dapkinase1
Function:
Calcium/calmodulin-dependent serine/threonine kinase which acts as a positive regulator of apoptosis.
Death Domain Subfamily & Boundary Region:
  • DD : 1312-1396 Seq
Species External DB Questionmark
Uniprot DIP STRING KEGG IntAct MINT
Human Seq P53355external db link DIP-34910Nexternal db link P53355external db link hsa:1612external db link P53355external db link MINT-1136108external db link
Mouse Seq Q80YE7external db link Q80YE7external db link mmu:69635external db link Q80YE7external db link
Rat Seq B5DFH6external db link
Dog Seq E2JE41external db link
Zebra fish Seq A5WVL9external db link A5WVL9external db link dre:558314external db link
Not solved yet
No information
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
DD DAPK1 Link FADD Co-Immunofluorescence staining Rat brain cell 12911633
DD DAPK1 Link FADD Co-immunoprecipitation Rat brain cell 12911633
DD DAPK1 Link FADD Co-immunoprecipitation Human Epilepsy brain lysate 15048887
DD DAPK1 Link FADD Co-immunoprecipitation MBA-MB-231 21168190
DD DAPK1 Link TNFR1 Co-Immunofluorescence staining Rat brain cell 12911633
DD DAPK1 Link TNFR1 Co-immunoprecipitation Rat brain cell 12911633
DD DAPK1 Link UNC5B Co-immunoprecipitation HEK293 Not specified Full length Not specified Full length 15729359
DD DAPK1 Link UNC5B Co-immunoprecipitation HEK293 Not specified Full length Not specified Not specified 15729359
DD DAPK1 Link UNC5B Co-immunoprecipitation HEK293 Not specified Full length Not specified 841-945 15729359
DD DAPK1 Link UNC5B Co-immunoprecipitation HEK293 Not specified Full length Not specified 631-945 15729359
DD DAPK1 Link UNC5B Co-immunoprecipitation HEK293 Not specified 1301-1431 Not specified Full length 15729359
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Functional Role
Family DD1 DD2 Method Death-related Death-unrelated Reference
DD DAPK1 Link UNC5B Trypan blue staining, Immunoprecipitation Apoptosis, DAPK kinase activity increase 15729359
(Link: click this icon to show interactions only between the two corresponding DDs)