DEDD (DED)

Full Name:
Death effector domain-containing protein
Alternative Names:
DEFT, KE05, DEDD1, FLDED1, CASP8IP1
Function:
A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro (By similarity).
Death Domain Subfamily & Boundary Region:
Species External DB Questionmark
Uniprot DIP STRING KEGG IntAct MINT
Human Seq O75618external db link DIP-41944Nexternal db link O75618external db link hsa:9191external db link O75618external db link MINT-201863external db link
Mouse Seq Q9Z1L3external db link Q9Z1L3external db link mmu:21945external db link
Rat Seq Q9Z2K0external db link Q9Z2K0external db link rno:83631external db link
Dog Seq E2RM82external db link cfa:488649external db link
Zebra fish Seq Q9I9M3external db link dre:58125external db link
Not solved yet
No information
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vitro interaction
  DD1 DD2 Reference
Family DD1 DD2 Method Species Region Expression Species Region Expression
DED DEDD Link Caspase8 GST fusion protein pull-down Human 1-318 In vitro translation Not specified Full length In vitro translation 9774341
DED DEDD Link Caspase8 GST fusion protein pull-down Human 1-318 In vitro translation Not specified 1-180 In vitro translation 9774341
DED DEDD Link Caspase8 GST fusion protein pull-down Not specified Full length E.coli Not specified 1-201 In vitro translation 11965497
DED DEDD Link DEDD GST fusion protein pull-down Not specified Full length E.coli Not specified Full length In vitro translation 11965497
DED DEDD Link DEDD2 GST fusion protein pull-down Not specified Full length E.coli Not specified Full length In vitro translation 11965497
DED DEDD Link DEDD2 GST fusion protein pull-down Not specified Full length In vitro translation Not specified Full length E.coli 11965497
DED DEDD Link DEDD2 GST fusion protein pull-down Not specified Not specified In vitro translation Not specified 1-115 E.coli 12527898
DED DEDD Link FADD GST fusion protein pull-down Human 1-318 In vitro translation Not specified Full length In vitro translation 9774341
DED DEDD Link FADD GST fusion protein pull-down Human 1-318 In vitro translation Not specified 1-88 In vitro translation 9774341
DED DEDD Link FLIP GST fusion protein pull-down Not specified Full length E.coli Human Full length In vitro translation 11965497
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
DED DEDD Link Caspase8 Co-immunoprecipitation HEK293 Human 1-318 Not used 9774341
DED DEDD Link Caspase8 GST fusion protein pull-down HEK293 Not specified Not specified Not specified Not specified 11741985
DED DEDD Link DEDD Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 12527898
DED DEDD Link DEDD2 Co-immunoprecipitation HEK293 Not specified Full length Not specified Full length 11965497
DED DEDD Link DEDD2 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Full length 12527898
DED DEDD Link DEDD2 Co-immunoprecipitation HEK293 Not specified Not specified Not specified 1-115 12527898
DED DEDD Link DEDD2 Co-immunoprecipitation HEK293 Not specified Full length Not specified Full length 12527898
DED DEDD Link DEDD2 Co-immunoprecipitation HEK293 Not specified Full length Not specified 1-115 12527898
DED DEDD Link FADD Co-immunoprecipitation HEK293 Human 1-318 Not used 9774341
DED DEDD Link FADD GST fusion protein pull-down HEK293 Not specified Not specified Not specified Not specified 11741985
DED DEDD Link FLIP GST fusion protein pull-down HEK293 Not specified Not specified Not specified Not specified 11741985
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Functional Role
Family DD1 DD2 Method Death-related Death-unrelated Reference
DED DEDD Link FADD Data not shown Apoptosis 9774341
(Link: click this icon to show interactions only between the two corresponding DDs)