DEDD2 (DED)

Full Name:
DNA-binding death effector domain-containing protein 2
Alternative Names:
FLAME-3
Function:
May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3.
Death Domain Subfamily & Boundary Region:
Species External DB Questionmark
Uniprot DIP STRING KEGG IntAct MINT
Human Seq Q8WXF8external db link Q8WXF8external db link hsa:162989external db link
Mouse Seq Q8QZV0external db link Q8QZV0external db link mmu:67379external db link
Dog Seq E2RK53external db link cfa:613012external db link
Zebra fish Seq F1QIL7external db link
Not solved yet
No information
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vitro interaction
  DD1 DD2 Reference
Family DD1 DD2 Method Species Region Expression Species Region Expression
DED DEDD2 Link Caspase8 GST fusion protein pull-down Not specified Full length E.coli Not specified 1-201 In vitro translation 11965497
DED DEDD2 Link DEDD GST fusion protein pull-down Not specified Full length In vitro translation Not specified Full length E.coli 11965497
DED DEDD2 Link DEDD GST fusion protein pull-down Not specified Full length E.coli Not specified Full length In vitro translation 11965497
DED DEDD2 Link DEDD GST fusion protein pull-down Not specified 1-115 E.coli Not specified Not specified In vitro translation 12527898
DED DEDD2 Link DEDD2 GST fusion protein pull-down Not specified Full length E.coli Not specified Full length In vitro translation 11965497
DED DEDD2 Link FLIP GST fusion protein pull-down Human Not specified E.coli Not specified Not specified In vitro translation 11741985
DED DEDD2 Link FLIP GST fusion protein pull-down Not specified Full length E.coli Human Full length In vitro translation 11965497
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
DED DEDD2 Link Caspase10 Co-immunoprecipitation HEK293 Not specified Full length Not specified Not specified 12527898
DED DEDD2 Link Caspase8 Co-immunoprecipitation HEK293 Not specified Full length Not specified Not specified 11965497
DED DEDD2 Link Caspase8 Co-immunoprecipitation HEK293 Not specified Full length Not specified Not specified 12527898
DED DEDD2 Link Caspase8 Co-immunoprecipitation HEK293 Not specified 1-115 Not specified Not specified 12527898
DED DEDD2 Link DEDD Co-immunoprecipitation HEK293 Not specified Full length Not specified Full length 11965497
DED DEDD2 Link DEDD Co-immunoprecipitation HEK293 Not specified Full length Not specified Not specified 12527898
DED DEDD2 Link DEDD Co-immunoprecipitation HEK293 Not specified 1-115 Not specified Not specified 12527898
DED DEDD2 Link DEDD Co-immunoprecipitation HEK293 Not specified Full length Not specified Full length 12527898
DED DEDD2 Link DEDD Co-immunoprecipitation HEK293 Not specified 1-115 Not specified Full length 12527898
DED DEDD2 Link DEDD2 Co-immunoprecipitation HEK293 Not specified Full length Not specified Full length 12527898
DED DEDD2 Link DEDD2 Co-immunoprecipitation HEK293 Not specified Full length Not specified 1-115 12527898
DED DEDD2 Link FLIP Co-Immunofluorescence staining MCF-7 Not specified Full length Not specified Not specified 11965497
DED DEDD2 Link FLIP Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 11741985
DED DEDD2 Link FLIP Co-immunoprecipitation HEK293 Not specified Full length Human Full length 11965497
(Link: click this icon to show interactions only between the two corresponding DDs)