DR3 (DD)

Full Name:
Tumor necrosis factor receptor superfamily member 25
Alternative Names:
TR3, DDR3, LARD, APO-3, TRAMP, WSL-1, WSL-LR, TNFRSF12, TNFRSF25
Function:
Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis.
Death Domain Subfamily & Boundary Region:
  • DD : 332-413 Seq
Species External DB Questionmark
Uniprot DIP STRING KEGG IntAct MINT
Human Seq Q93038external db link Q93038external db link hsa:8718external db link
Mouse Seq Q99MM1external db link Q99MM1external db link
Rat Seq D3ZB39external db link
Dog Seq F1Q452external db link
Zebra fish Seq E7FDJ7external db link
Not solved yet
No information
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vitro interaction
  DD1 DD2 Reference
Family DD1 DD2 Method Species Region Expression Species Region Expression
DD DR3 Link DR3 Yeast two-hybrid Not specified Not specified Yeast Not specified Not specified Yeast 8934525
DD DR3 Link TNFR1 Yeast two-hybrid Not specified Not specified Yeast Human Not specified Yeast 8934525
DD DR3 Link TRADD GST fusion protein pull-down Human 215-393 E.coli Not specified Not specified In vitro translation 8875942
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
DD DR3 Link DR3 Co-immunoprecipitation HEK293 Human 332-413 Human 332-413 9052839
DD DR3 Link FADD Co-immunoprecipitation HEK293 Human 332-413 Not specified Not specified 9052839
DD DR3 Link FADD Co-immunoprecipitation HEK293 Human 27-418 Human Not specified 9430227
DD DR3 Link TRADD Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 8934525
DD DR3 Link TRADD Co-immunoprecipitation HEK293 Human Not specified Not specified Not specified 9430227
DD DR3 Link TRADD Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 9714541
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Characterization
  Stoichiometry Affinity Protein-Protein interface Reference
Family DD1 DD2 Method Mutation Complex structure
DD DR3 Link DR3 Yeast two-hybrid L354A, L356A, D373A (DR3) 8934525
DD DR3 Link TNFR1 Yeast two-hybrid L354A, L356A, D373A (DR3) 8934525
(Link: click this icon to show interactions only between the two corresponding DDs)