DR5 (DD)

Full Name:
Tumor necrosis factor receptor superfamily member 10B
Alternative Names:
CD262, KILLER, TRICK2, TRICKB, ZTNFR9, TRAILR2, TRICK2A, TRICK2B, TRAIL-R2, KILLER/DR5, TNFRSF10B
Function:
Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.
Death Domain Subfamily & Boundary Region:
  • DD : 339-422 Seq
Species External DB Questionmark
Uniprot DIP STRING KEGG IntAct MINT
Human Seq O14763external db link DIP-33566Nexternal db link O14763external db link hsa:8795external db link O14763external db link MINT-109111external db link
Mouse Seq Q9QZM4external db link Q9QZM4external db link mmu:21933external db link Q9QZM4external db link
Rat Seq B8YBG7external db link B8YBG7external db link
Not solved yet
Disease Mutation in disease Reference
Squamous cell carcinoma (SCC) 9721851
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vitro interaction
  DD1 DD2 Reference
Family DD1 DD2 Method Species Region Expression Species Region Expression
DD DR5 Link DR4 Affinity purification-mass spectrometry H460cell lyaste H460cell lyaste 19427028
DD DR5 Link FADD GST fusion protein pull-down Not specified 191-411 E.coli Jurkat lysate 12721308
DD DR5 Link FADD GST fusion protein pull-down Not specified 209-411 E.coli HeLa lysate 12920112
DD DR5 Link FADD Yeast two-hybrid Not specified 209-412 Yeast Not specified Full length Yeast 15173180
DD DR5 Link FADD Yeast two-hybrid Not specified 209-412 Yeast Not specified Full length Yeast 15452120
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
DD DR5 Link DR4 Co-immunoprecipitation HeLa 16980609
DD DR5 Link DR5 Size-exclusion chromatography HeLa 17585340
DD DR5 Link FADD Co-immunoprecipitation HEK293 Human 51-411 Human Not specified 9430227
DD DR5 Link FADD Co-immunoprecipitation HEK293 Not specified 232-439 Not specified 80-208 9430228
DD DR5 Link FADD Co-immunoprecipitation BJAB 15173180
DD DR5 Link FADD Co-immunoprecipitation HeLa Not specified 79-208 Not specified 272-469 15173180
DD DR5 Link FADD Co-immunoprecipitation BJAB Not specified 209-412 Not specified Full length 15452120
DD DR5 Link FADD Co-immunoprecipitation HepG2 16980609
DD DR5 Link FADD Co-immunoprecipitation HeLa 17585340
DD DR5 Link FADD Co-immunoprecipitation SW948 21272366
DD DR5 Link MADD Co-immunoprecipitation HEK293 Not specified Not specified Human Full length 15208670
DD DR5 Link MADD Co-immunoprecipitation HEK293 Not specified Not specified Human 628-1376 15208670
DD DR5 Link RIP Co-immunoprecipitation HEK293 Human 51-411 Human Not specified 9430227
DD DR5 Link TRADD Co-immunoprecipitation HEK293 Human 51-411 Human 121-312 9430227
DD DR5 Link TRADD Co-immunoprecipitation HEK293 Not specified 261-465 Not specified Not specified 9430228
DD DR5 Link TRADD Co-immunoprecipitation HEK293 Not specified 232-439 Not specified Not specified 9430228
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Functional Role
Family DD1 DD2 Method Death-related Death-unrelated Reference
DD DR5 Link FADD β-galactosidase staining Apoptosis (DISC) 9430227
DD DR5 Link FADD Cytoplasmic histone associated DNA fragment detection Apoptosis (DISC) 9430228
DD DR5 Link FADD Caspase cleaved assay Caspase8 activation 15452120
DD DR5 Link FADD Immunofluorescence staining Apoptosis (DISC) 21272366
DD DR5 Link FADD Annexin V staining Apoptosis (DISC) 12920112
DD DR5 Link MADD Immunofluorescence staining Apoptosis (DISC) 15208670
DD DR5 Link TRADD Luciferase assay NF-kB activation 9430227
(Link: click this icon to show interactions only between the two corresponding DDs)