EDAR (DD)

Full Name:
Tumor necrosis factor receptor superfamily member EDAR
Alternative Names:
DL, ED3, ED5, ED1R, EDA3, HRM1, EDA1R, EDA-A1R, FLJ94390
Function:
Receptor for EDA isoform A1, but not for EDA isoform A2. Mediates the activation of NF-kappa-B and JNK. May promote caspase-independent cell death.
Death Domain Subfamily & Boundary Region:
  • DD : 358-431 Seq
Species External DB Questionmark
Uniprot DIP STRING KEGG IntAct MINT
Human Seq Q9UNE0external db link DIP-33587Nexternal db link Q9UNE0external db link hsa:10913external db link Q9UNE0external db link
Mouse Seq Q9R187external db link Q9R187external db link mmu:13608external db link
Rat Seq D3ZGP2external db link rno:365581external db link
Dog Seq E2R2Q1external db link
Zebra fish Seq B0YIF2external db link B0YIF2external db link dre:796370external db link
Not solved yet
Disease Mutation in disease Reference
Ectodermal dysplasia R375H 15373768
Ectodermal dysplasia G382S 16029325
Ectodermal dysplasia E354X, R89H, D110A 18231121
Ectodermal dysplasia 18816645
Hair thickness V370A 18065779
Hair thickness V370A 18561327
Hair thickness V370A 18704500
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vitro interaction
  DD1 DD2 Reference
Family DD1 DD2 Method Species Region Expression Species Region Expression
DD EDAR Link EDARADD GST fusion protein pull-down Not specified 212-448 E.coli Human Not specified In vitro translation 11780064
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
DD EDAR Link EDARADD Co-immunoprecipitation HEK293 Not specified 212-448 Human Not specified 11780064
DD EDAR Link EDARADD Co-immunoprecipitation HEK293 Mouse Full length Human Not specified 17354266
DD EDAR Link EDARADD Co-immunoprecipitation HEK293 Not specified Not specified Human Not specified 20222921
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Characterization
  Stoichiometry Affinity Protein-Protein interface Reference
Family DD1 DD2 Method Mutation Complex structure
DD EDAR Link EDARADD GST fusion protein pull-down E142K (EDARADD) 11780064
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Functional Role
Family DD1 DD2 Method Death-related Death-unrelated Reference
DD EDAR Link EDARADD Luciferase assay NF-kB activation 11780064
DD EDAR Link EDARADD Luciferase assay NF-kB activation 17354266
(Link: click this icon to show interactions only between the two corresponding DDs)