EDARADD (DD)

Full Name:
Ectodysplasin-A receptor-associated adapter protein
Alternative Names:
ED3, EDA3
Function:
Adapter protein that interacts with EDAR DEATH domain and couples the receptor to EDA signaling pathway during morphogenesis of ectodermal organs. Mediates the activation of NF-kappa-B.
Death Domain Subfamily & Boundary Region:
  • DD : 123-202 Seq
Species External DB Questionmark
Uniprot DIP STRING KEGG IntAct MINT
Human Seq Q8WWZ3external db link Q8WWZ3external db link hsa:128178external db link Q8WWZ3external db link
Mouse Seq Q8VHX2external db link Q8VHX2external db link
Rat Seq F1LYE0external db link
Dog Seq E2QWH4external db link
Not solved yet
Disease Mutation in disease Reference
Ectodermal dysplasia E142K 11780064
Ectodermal dysplasia L112R 17354266
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vitro interaction
  DD1 DD2 Reference
Family DD1 DD2 Method Species Region Expression Species Region Expression
DD EDARADD Link EDAR GST fusion protein pull-down Human Not specified In vitro translation Not specified 212-448 E.coli 11780064
DD EDARADD Link EDARADD GST fusion protein pull-down Human Not specified In vitro translation Human Not specified E.coli 11780064
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
DD EDARADD Link EDAR Co-immunoprecipitation HEK293 Human Not specified Not specified 212-448 11780064
DD EDARADD Link EDAR Co-immunoprecipitation HEK293 Human Not specified Mouse Full length 17354266
DD EDARADD Link EDAR Co-immunoprecipitation HEK293 Human Not specified Not specified Not specified 20222921
DD EDARADD Link EDARADD Co-immunoprecipitation HEK293 Human Not specified Human Not specified 11780064
DD EDARADD Link EDARADD Co-immunoprecipitation HEK293 Human Not specified Human Not specified 17354266
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Characterization
  Stoichiometry Affinity Protein-Protein interface Reference
Family DD1 DD2 Method Mutation Complex structure
DD EDARADD Link EDAR GST fusion protein pull-down E142K (EDARADD) 11780064
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Functional Role
Family DD1 DD2 Method Death-related Death-unrelated Reference
DD EDARADD Link EDAR Luciferase assay NF-kB activation 11780064
DD EDARADD Link EDAR Luciferase assay NF-kB activation 17354266
(Link: click this icon to show interactions only between the two corresponding DDs)