IFI16 (PYD)

Full Name:
Gamma-interferon-inducible protein 16
Alternative Names:
PYHIN2, IFNGIP1, MGC9466
Function:
May function as a transcriptional repressor. Could have a role in the regulation of hematopoeitic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in the senescence of prostate epithelial cells.
Death Domain Subfamily & Boundary Region:
Species External DB Questionmark
Uniprot DIP STRING KEGG IntAct MINT
Human Seq Q16666external db link DIP-42868Nexternal db link Q16666external db link hsa:3428external db link Q16666external db link MINT-1781545external db link
Not solved yet
No information
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
PYD IFI16 Link ASC Co-Immunofluorescence staining HMVEC-d 21575908
PYD IFI16 Link ASC Co-immunoprecipitation HMVEC-d 21575908
(Link: click this icon to show interactions only between the two corresponding DDs)