IRAK2 (DD)

Full Name:
Interleukin-1 receptor-associated kinase-like 2
Alternative Names:
IRAK-2, MGC150550
Function:
Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.
Death Domain Subfamily & Boundary Region:
  • DD : 13-94 Seq
Species External DB Questionmark
Uniprot DIP STRING KEGG IntAct MINT
Human Seq O43187external db link DIP-31800Nexternal db link O43187external db link hsa:3656external db link O43187external db link MINT-97184external db link
Mouse Seq Q8CFA1external db link Q8CFA1external db link mmu:108960external db link Q8CFA1external db link
Rat Seq Q4QQS0external db link Q4QQS0external db link rno:362418external db link
Dog Seq E2RDA4external db link
Structure Species Residue Method Expression Purification Column Final condition Final concentration Reference
3MOP Download Human 1-112 X-ray E.coli Gel filtration Superdex 200 1mg/ml 20485341
No information
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vitro interaction
  DD1 DD2 Reference
Family DD1 DD2 Method Species Region Expression Species Region Expression
DD IRAK2 Link Myd88 GST fusion protein pull-down Not specified Full length In vitro translation Not specified 1-296 E.coli 12659850
DD IRAK2 Link Myd88 GST fusion protein pull-down Not specified Full length In vitro translation Not specified 1-109 E.coli 12659850
DD IRAK2 Link Myd88 GST fusion protein pull-down Not specified Full length In vitro translation Not specified 1-155 E.coli 12659850
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
DD IRAK2 Link IRAK1 Co-immunoprecipitation HEK293 Not specified Full length Not specified Full length 10383454
DD IRAK2 Link IRAK1 Fluorescence resonance energy transfer NIH 3T3 Not specified Full length Not specified Not specified 12138165
DD IRAK2 Link IRAK2 Co-immunoprecipitation HEK293 Not specified Full length Not specified Full length 10383454
DD IRAK2 Link IRAK3 Co-immunoprecipitation HEK293 Not specified Full length Human Full length 10383454
DD IRAK2 Link IRAK4 His fusion protein pull-down E.coli Human 1-112 Human 4-106 20485341
DD IRAK2 Link Myd88 Co-immunoprecipitation HEK293 Human Full length Human Full length 9374458
DD IRAK2 Link Myd88 Co-immunoprecipitation HEK293 Not specified Full length Not specified 1-151 10383454
DD IRAK2 Link Myd88 His fusion protein pull-down E.coli Human 1-112 Human 20-117 20485341
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Characterization
  Stoichiometry Affinity Protein-Protein interface Reference
Family DD1 DD2 Method Mutation Complex structure
DD IRAK2 Link IRAK4 Structure 6:4:4 Y6D, W62D, M66D, R67D (IRAK2) 3MOP 20485341
DD IRAK2 Link Myd88 Structure 6:4:4 3MOP 20485341
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Functional Role
Family DD1 DD2 Method Death-related Death-unrelated Reference
DD IRAK2 Link IRAK1 Kinase assay IRAK2 activation 10383454
DD IRAK2 Link Myd88 Luciferase assay NF-kB activation (Myddosome) 9374458
(Link: click this icon to show interactions only between the two corresponding DDs)